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Articles 121 - 150 of 153
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Loss Of The Na+/H+ Exchange Regulatory Factor 1 Results In Increased Susceptibility To Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle
Loss Of The Na+/H+ Exchange Regulatory Factor 1 Results In Increased Susceptibility To Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle
Electronic Theses and Dissertations
Background. Acute kidney injury (AKI), an abrupt loss of kidney function which carries a high mortality and confers an increased risk of chronic kidney disease, develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent [1], [2], [3]. The sodium hydrogen exchange regulatory factor isoform 1 (NHERF1) is a scaffolding protein that anchors multiple membrane proteins, in renal proximal tubules [4]. NHERF-1 deficient mice have aberrant localization of BBM proteins in intracellular compartments [5]. The investigators have recently demonstrated NHERF1 deficient proximal tubule cells have an underlying …
Enhancement Of Nafld Risk By Vinyl Chloride : Role Of Adipose Tissue In A Mouse Model., Brenna R. Kaelin
Enhancement Of Nafld Risk By Vinyl Chloride : Role Of Adipose Tissue In A Mouse Model., Brenna R. Kaelin
College of Arts & Sciences Senior Theses
Background: Vinyl chloride (VC), an environmental contaminant, is directly hepatotoxic at high concentrations. However, our group has recently demonstrated that VC and the VC metabolite chloroethanol (CE), at concentrations that are not considered hepatotoxic, enhanced liver injury caused by high-fat diet (HFD). These data therefore suggest that the impact of VC exposure on hepatic tissue may be enhanced with underlying metabolic syndrome and/or liver injury. It is known that there is an axis between adipose and hepatic tissue in non-alcoholic fatty liver disease (NAFLD), with the former impacting pathology in the hepatic tissue via release of pro-inflammatory cytokines and/or lipolysis. …
The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi
Electronic Theses and Dissertations
Polychlorinated biphenyls (PCBs) are detectable in serum of 100% of adults in US, and has been associated with fatty liver disease in epidemiological studies. PCBs are classified as either dioxin-like (DL) or non-dioxin-like (NDL) PCB based on their ability to activate the aryl hydrocarbon receptor (AhR). We used exposures that reflect human bioaccumulation patterns, which resembles Aroclor 1260 with a low level of the DL-PCB, PCB 126. Our aim was to determine if this exposure will activate the human and mouse AhR and examine if receptor activation influences these steatotic responses due to PCB exposures. DL-PCBs exposure-induced AhR activation in …
Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang
Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang
Electronic Theses and Dissertations
Background. Vinyl chloride (VC) is an environmental toxicant and has been shown to be directly hepatotoxic at high exposures. However, recent studies suggest low-level toxicant exposure can cause subtle changes to the liver. Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) in the United States, it is important to determine the impact of low-level toxicant exposure on the progression of underlying liver injury when combined with other factors. Therefore, the overarching goal of this dissertation was to develop a model of VC co-exposure with high-fat diet (HFD) and to determine the mechanisms by which VC contributes to the …
A Model To Study The Effects Of Whole Life Chronic Exposure To Arsenic Or Cadmium On The Development Of Adult Metabolic Syndrome : Initial Characterization Of Hepatic Changes., Jamie L. Young
Electronic Theses and Dissertations
Metabolic syndrome (MetS) is a group of diseases affecting < 30% of adults. Although obesity is a major risk for the development of MetS, it does not account for all cases, suggesting contribution of other risk factors. We hypothesized that early life exposure to arsenic (As) or cadmium (Cd) may represent such a risk. The purpose of this study was to characterize a model to discern the effects of early life exposures to Cd and As on high fat diet (HFD)-induced MetS. Adult C57BL/6J mice were exposed to control or metals containing drinking water. Pregnant dams and offspring were continuously exposed to the same toxicants as their parents. At weaning, offspring were fed LFD or HFD and sacrificed 10 or 24 weeks later. Metal exposure caused time- and sex-dependent alterations in HFD-induced variables of liver damage. The initial results suggest that these toxicants enhanced obesity-induced liver injury.
A Cluster-Randomized Trial To Evaluate The Impact Of An Inclusive, Community-Led Total Sanitation Intervention On Sanitation Access For People With Disabilities In Malawi., Adam Biran, Lisa Danquah, Joseph Chunga, Wolf Peter Schmidt, Rochelle Holm, Ambumulire Itimu-Phiri, Wales Singini, Hazel Jones, Hannah Kuper, Sian White
A Cluster-Randomized Trial To Evaluate The Impact Of An Inclusive, Community-Led Total Sanitation Intervention On Sanitation Access For People With Disabilities In Malawi., Adam Biran, Lisa Danquah, Joseph Chunga, Wolf Peter Schmidt, Rochelle Holm, Ambumulire Itimu-Phiri, Wales Singini, Hazel Jones, Hannah Kuper, Sian White
Faculty and Staff Scholarship
Community-led total sanitation (CLTS) is a common method for promoting sanitation in low-income settings. This cluster-randomized trial evaluated an intervention to improve inclusion of people with disability in CLTS through training facilitators. A qualitative study examined intervention acceptability. The trial included 171 people with disabilities (78 control and 93 intervention) living in 15 intervention and 15 control communities. In the intervention arm, respondents were more likely to participate in a community meeting about sanitation (+18.7%, 95% confidence interval [CI]: 3.2, 34.2) and to have been visited to discuss sanitation (+19.7, 95% CI: 0.6, 37.8). More intervention households improved latrine access …
Age-Related Host Factors Regulate Lung Cancer Progression., John Caleb Greenwell
Age-Related Host Factors Regulate Lung Cancer Progression., John Caleb Greenwell
Electronic Theses and Dissertations
Cancer is largely a disease of the elderly. In the United States alone, 87% of all cancers in 2017 will be diagnosed in individuals aged 50 years or older. Among them, lung cancer is the deadliest, accounting for 1 in 4 cancer deaths. The 5-year survival rate is below 20%, a number which has not changed substantially over the past several decades. This underscores a desperate need for new strategies in prevention, early detection and treatment of this deadly disease. While tobacco use is unquestionably the number one risk factor for the development of lung cancer, the majority of diagnoses …
The Handpump Choice Is Yours: A Pilot Study In Rumphi District, Malawi., Rochelle Holm, Alinafe Kamangira, Victor Kasulo, Prince Kaponda, Edwin Hara, Channing Carney-Filmore, Muthi Nhlema
The Handpump Choice Is Yours: A Pilot Study In Rumphi District, Malawi., Rochelle Holm, Alinafe Kamangira, Victor Kasulo, Prince Kaponda, Edwin Hara, Channing Carney-Filmore, Muthi Nhlema
Faculty and Staff Scholarship
In sub-Saharan Africa, moving towards the Sustainable Development Goals will require an approach to water and sanitation service delivery for many rural communities where handpumps still dominate infrastructure. This paper reviews a case study of allowing users (local government and communities) in Rumphi District, Malawi, to choose a handpump model based on information about the life-cycle costs. The results indicate that there is some awareness within communities and within the local government of several handpump options for the rural water supply in the study area. Given a choice of different handpump models in the treatment communities, each community chose the …
Sphingolipids In Models Of Kidney Disease And Injury., Tess V. Dupre
Sphingolipids In Models Of Kidney Disease And Injury., Tess V. Dupre
Electronic Theses and Dissertations
Acute kidney injury (AKI), resulting from cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves cell death pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results indicate that cisplatin-treated mice had increased levels of ceramide and hexosylceramide. Pre-treatment of mice with inhibitors of ceramide synthesis prevented accumulation of ceramide and hexosylceramide in the renal cortex and attenuated cisplatin-induced AKI. To determine the role of ceramide metabolism to hexosylceramides in kidney injury, we treated mice with an inhibitor of glycosphingolipid synthesis. Inhibition of glycosphingolipid synthesis attenuated the accumulation of the hexosylceramide and exacerbated ceramide accumulation in the …
Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole
Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole
Electronic Theses and Dissertations
Background. Individuals who chronically abuse alcohol are almost 4 times more likely to develop Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), but the mechanisms by which alcohol abuse sensitizes the lung to injury are poorly understood. However, the lung appears to share many parallel mechanisms of injury with the liver- a primary target of alcohol abuse. The overarching goal of this dissertation was therefore to expand on established mechanisms of alcohol-induced liver injury to ask innovative questions about mechanisms of alcohol-enhanced acute lung injury, as well as to develop new tools that may …
Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda
Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda
Electronic Theses and Dissertations
Despite continuous improvement and significant progress made in diagnostic and therapeutic approaches for cancer, it is still the leading cause of death worldwide. Although conventional chemotherapy has made significant advances in improving patient survival the indiscriminate destruction of normal cells leads to severe side effects and poor clinical outcomes. Thus, there is a need for effective delivery of drugs to the tumor site avoiding normal tissues to reduce toxicity in the rest of the body. For this reason, a novel multidisciplinary field called Nanotechnology has evolved in recent years and advances in this field have contributed to the development of …
Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd
Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd
Electronic Theses and Dissertations
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. Familial adenomatous polyposis (FAP) is an inherited disorder which if left untreated will develop into colon cancer. The family of plant-derived compounds, anthocyanins, show significant therapeutic potential against a variety of diseases, however, they are limited by their instability and poor bioavailability. The goal of my Master’s research project was to determine whether anthocyanidins (non-glycosylated anthocyanins) are more effective than the native anthocyanins, and whether exosomal formulation of anthocyanidins (ExoAnthos) can enhance therapeutic potency compared with free Anthos against both FAP and CRC. The antiproliferative …
The Comparative Cytotoxicity And Genotoxicity Of Hexavalent Chromium In Humans And Sea Turtles., Rachel M. Speer
The Comparative Cytotoxicity And Genotoxicity Of Hexavalent Chromium In Humans And Sea Turtles., Rachel M. Speer
Electronic Theses and Dissertations
Monitoring the health effects of environmental contaminants can be achieved using sentinel species as models. Leatherback sea turtles (Dermochelys coriacea) are an endangered marine species that may experience prolonged exposures to environmental contaminants including hexavalent chromium [Cr(VI)]. While Cr(VI) has been identified as a known human carcinogen, the health effects in marine species are poorly understood. In this study the cytotoxic and genotoxic effects of particulate and soluble Cr(VI) were assessed in leatherback lung cells and compared to those in human lung cells. Cr(VI) induced a concentration-dependent increase in cytotoxicity and genotoxicity in leatherback lung cells indicating Cr(VI) …
Designing Local Solutions For Emptying Pit Latrines In Low-Income Urban Settlements (Malawi)., W. C. Chipeta, R. H. Holm, J. F. Kamanula, W. E. Mtonga, F. L. De Los Reyes
Designing Local Solutions For Emptying Pit Latrines In Low-Income Urban Settlements (Malawi)., W. C. Chipeta, R. H. Holm, J. F. Kamanula, W. E. Mtonga, F. L. De Los Reyes
Faculty and Staff Scholarship
A lack of effective options in local technology poses challenges when onsite household sanitation facilities are eventually filled to capacity in unplanned settlement areas within Mzuzu City, located in northern Malawi. Vacuum trucks currently dominate the market but focus on emptying septic tanks in the more easily accessible planned settlement areas, rather than servicing the pit latrines common in unplanned settlement areas. As a result, households in the unplanned settlement areas within Mzuzu rely primarily on manual pit emptying (i.e., shoveling by hand) or digging a new pit latrine. These practices have associated health risks and are limited by space …
Reducing The Burden Of Rural Water Supply Through Greywater Reuse: A Case Study From Northern Malawi., Evan Newcomer, Courtney Boyd, Laban Nyirenda, Emmanuel Opong, Shannon Marquez, Rochelle Holm
Reducing The Burden Of Rural Water Supply Through Greywater Reuse: A Case Study From Northern Malawi., Evan Newcomer, Courtney Boyd, Laban Nyirenda, Emmanuel Opong, Shannon Marquez, Rochelle Holm
Faculty and Staff Scholarship
Greywater reuse has potential for non-potable applications that conserve freshwater resources in water-stressed areas especially in sub-Saharan Africa. The feasibility of reusing greywater for domestic activities in a rural area of Malawi, Africa, was evaluated from microbiological and public acceptance perspectives. Median Escherichia coli concentrations for eight domestic greywater sources (handwashing, laundry, runoff from a tap apron, bathing, cleaning a home/kitchen, cleaning a water collection container, washing plates and soaking vegetables) ranged from 100 to >20, 000 colony forming units (cfu)/100 ml. Twenty-four of 47 greywater samples tested (51%) met the World Health Organization guideline for unrestricted use of greywater …
Trash Removal Methods For Improved Mechanical Emptying Of Pit Latrines Using A Screw Auger., Tracey Sisco, Tate Rogers, Walt Beckwith, Willy Chipeta, Rochelle Holm, Christopher A. Buckley, Francis L. De Los Reyes
Trash Removal Methods For Improved Mechanical Emptying Of Pit Latrines Using A Screw Auger., Tracey Sisco, Tate Rogers, Walt Beckwith, Willy Chipeta, Rochelle Holm, Christopher A. Buckley, Francis L. De Los Reyes
Faculty and Staff Scholarship
Trash in pit latrines is one of the largest challenges facing pit emptying technologies, including the powered auger (the Excrevator), developed for improved emptying in lower- and lower-middle income countries. This study focused on two trash removal methods in conjunction with pit emptying by the Excrevator: (1) simultaneous removal of trash with sludge and (2) manual trash removal prior to sludge removal. Simultaneous removal was tested by adding to the inlet of the Excrevator system two cutting heads designed to reduce the size of trash particles before entering the pipe and auger. Laboratory testing indicated that the auger will not …
Characterization Of Pit Latrines To Support The Design And Selection Of Emptying Tools In Peri-Urban Mzuzu, Malawi., Rashid Chiposa, Rochelle H. Holm, Chimuleke Munthali, Russel C.G. Chidya, Francis L. De Los Reyes
Characterization Of Pit Latrines To Support The Design And Selection Of Emptying Tools In Peri-Urban Mzuzu, Malawi., Rashid Chiposa, Rochelle H. Holm, Chimuleke Munthali, Russel C.G. Chidya, Francis L. De Los Reyes
Faculty and Staff Scholarship
The urban areas of many low-income countries must balance a rising demand for pit latrines for household sanitation provision against limitations in space, resulting in a need for pit latrine emptying services. This study was undertaken in the peri-urban neighborhood of Area 1B in the city of Mzuzu, Malawi, to examine the characteristics of household pit latrines for designing and selecting pit latrine emptying tools. We used 150 structured household surveys and field observations. From this, a subset was selected and 30 manual cone penetrometer tests were conducted at full latrines. Chemical oxygen demand analysis was also performed for 14 …
Pit Latrine Fecal Sludge Resistance Using A Dynamic Cone Penetrometer In Low Income Areas In Mzuzu City, Malawi., Charles F.C. Chirwa, Ralph P. Hall, Leigh Anne H. Krometis, Eric A. Vance, Adam Edwards, Ting Guan, Rochelle H. Holm
Pit Latrine Fecal Sludge Resistance Using A Dynamic Cone Penetrometer In Low Income Areas In Mzuzu City, Malawi., Charles F.C. Chirwa, Ralph P. Hall, Leigh Anne H. Krometis, Eric A. Vance, Adam Edwards, Ting Guan, Rochelle H. Holm
Faculty and Staff Scholarship
Pit latrines can provide improved household sanitation, but without effective and inexpensive emptying options, they are often abandoned once full and may pose a public health threat. Emptying techniques can be difficult, as the sludge contents of each pit latrine are different. The design of effective emptying techniques (e.g., pumps) is limited by a lack of data characterizing typical in situ latrine sludge resistance. This investigation aimed to better understand the community education and technical engineering needs necessary to improve pit latrine management. In low income areas within Mzuzu city, Malawi, 300 pit latrines from three distinct areas were assessed …
Adopters And Non-Adopters Of Low-Cost Household Latrines: A Study Of Corbelled Pit Latrines In 15 Districts Of Malawi., Rochelle Holm, Mavuto Tembo, Dalo Njera, Victor Kasulo, Mphatso Malota, Willy Chipeta, Wales Singini, Joshua Mchenga
Adopters And Non-Adopters Of Low-Cost Household Latrines: A Study Of Corbelled Pit Latrines In 15 Districts Of Malawi., Rochelle Holm, Mavuto Tembo, Dalo Njera, Victor Kasulo, Mphatso Malota, Willy Chipeta, Wales Singini, Joshua Mchenga
Faculty and Staff Scholarship
The Sustainable Development Goals will challenge low- and middle-income settings to look at new approaches for rural sanitation. In 2013, Mzuzu University, in partnership with United Nations Children's Fund (UNICEF) Malawi, started a low-cost latrine program in rural areas using the corbelled latrine design supported by locally owned sustainable businesses. The objective of this work was to trace customers (early household adopters) and non-customers through field observations and interviews in 15 districts of Malawi. The research team spent 193 personnel work days in data collection and found 21 households as adopters in 7 districts. Most respondents had a preference with …
Air Pollution, Pulmonary Oxidative Stress, And The Endothelin System In The Development Of Cardiovascular Injury., Jordan B. Finch
Air Pollution, Pulmonary Oxidative Stress, And The Endothelin System In The Development Of Cardiovascular Injury., Jordan B. Finch
Electronic Theses and Dissertations
The goal of this project was to examine the role of endothelin-1 (ET-1) as a mediator in the pathway between air pollution exposure and the development of vascular injury. A human cohort and male mice (C57BL/6 and ecSOD-Tg) were used to evaluate changes in the ET-1 system in response to exposures of fine particulate matter (PM2.5). Human ET-1 levels were significantly associated with environmental factors and markers of vascular change, but were decreased with increased PM2.5. No association was seen between ET-1 and endothelial progenitor cells (EPCs) except for EPC-4, possibly indicating a regulatory relationship with this specific population. In …
Isolation Of Egfr-Containing Early Endosomes., Julie A. Gosney
Isolation Of Egfr-Containing Early Endosomes., Julie A. Gosney
Electronic Theses and Dissertations
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that is an integral component of proliferative signaling. When activated by a ligand at the plasma membrane, EGFR undergoes clathrin-mediated endocytosis. This spatial regulation of the receptor is an important regulator of receptor expression as it mediates its degradation. Endocytosis also has implications on EGFR downstream signaling, though the details are not fully understood. The goal of this thesis is to develop a method to isolate early endosomes in order to study downstream effectors associated with activated EGFR in this compartment. HeLa cells were used to test various …
The Role Of The Nucleolus In Neurodegeneration., Justin Lauren Hallgren
The Role Of The Nucleolus In Neurodegeneration., Justin Lauren Hallgren
Electronic Theses and Dissertations
The overarching goal of my studies was to determine the role of the nucleolus in neurodegenerative disease. Numerous studies suggest the impairment of ribosomal biogenesis in neurodegenerative disease and such a condition may contribute to neuronal dysfunction in two ways, loss of function and stress response. Ribosomal biogenesis has been demonstrated to play an essential role in both neuronal growth and maintenance. Therefore insufficient levels of ribosomal biogenesis would be expected to produce atrophy and synapse loss. Moreover, the fidelity of ribosomal biogenesis is monitored by nucleolar and ribosomal stress responses which induce apoptosis and/or cell cycle arrest. Therefore, I …
Achieving The Sustainable Development Goals: A Case Study Of The Complexity Of Water Quality Health Risks In Malawi., Rochelle Holm, Philip Wandschneider, Allan Felsot, Golden Msilimba
Achieving The Sustainable Development Goals: A Case Study Of The Complexity Of Water Quality Health Risks In Malawi., Rochelle Holm, Philip Wandschneider, Allan Felsot, Golden Msilimba
Faculty and Staff Scholarship
RESULTS: The water quality data and human dimension questionnaire results were used to develop a household risk presentation. Sixty-seven percent and 50 % of well water and household drinking water samples, respectively, exceeded the WHO health guideline of zero detections of E. coli. Technology transfer was advanced by providing knowledge through household risk debriefing/education, establishing a water quality laboratory at the local university, and providing training to local technicians.
Access To Groundwater And Link To The Impact On Quality Of Life: A Look At The Past, Present And Future Public Health Needs In Mzimba District, Malawi., R. C.G. Chidya, R. H. Holm, M. Tembo, B. Cole, P. Workneh, J. Kanyama
Access To Groundwater And Link To The Impact On Quality Of Life: A Look At The Past, Present And Future Public Health Needs In Mzimba District, Malawi., R. C.G. Chidya, R. H. Holm, M. Tembo, B. Cole, P. Workneh, J. Kanyama
Faculty and Staff Scholarship
Imagine a world where you have to get up at 4am to walk for two hours in the dark to fetch water. This remains true in Malawi, where it is said that the Millennium Development Goals have been met. This research aimed at understanding the impact access to groundwater has on people's ‘Being’, ‘Belonging’ and ‘Becoming,’ as well as on people's capabilities and on their quality of life in Mzimba District, Malawi. Being, Belonging and Becoming define three life domains. Being reveals ‘who one is,’ Belonging reflects ‘connections with one's environments’ and Becoming relates to ‘achieving personal goals, hopes and …
A Qualitative Study Of Barriers To Accessing Water, Sanitation And Hygiene For Disabled People In Malawi., Sian White, Hannah Kuper, Ambumulire Itimu-Phiri, Rochelle Holm, Adam Biran
A Qualitative Study Of Barriers To Accessing Water, Sanitation And Hygiene For Disabled People In Malawi., Sian White, Hannah Kuper, Ambumulire Itimu-Phiri, Rochelle Holm, Adam Biran
Faculty and Staff Scholarship
Globally, millions of people lack access to improved water, sanitation and hygiene (WASH). Disabled people, disadvantaged both physically and socially, are likely to be among those facing the greatest inequities in WASH access. This study explores the WASH priorities of disabled people and uses the social model of disability and the World Health Organization's International Classification of Functioning, Disability and Health (ICF) framework to look at the relationships between impairments, contextual factors and barriers to WASH access. 36 disabled people and 15 carers from urban and rural Malawi were purposively selected through key informants. The study employed a range of …
A Plant-Made Cholera Toxin B Subunit Enhances Mucosal Wound Healing And Protects Against Ulcerative Colitis And Colon Cancer., Keegan J Baldauf
A Plant-Made Cholera Toxin B Subunit Enhances Mucosal Wound Healing And Protects Against Ulcerative Colitis And Colon Cancer., Keegan J Baldauf
Electronic Theses and Dissertations
This dissertation describes the previously unidentified effects of a plant-produced recombinant cholera toxin B subunit (CTBp) on the gastrointestinal (GI) tract and its ability to protect against inflammation in a mouse model of colonic injury and ulcerative colitis (UC). To comprehensively analyze CTBp’s impacts on the GI tract, we employed global analysis methodologies based on multi-color flow cytometry to analyze immune cell populations in GI and systemic lymphatic compartments, gene expression microarray to decipher transcript-level changes in the colon and small intestine, and 16S rRNA sequencing to characterize fecal microbiota. Based on a drastic shift observed in the immune cell …
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Electronic Theses and Dissertations
Chronic alcohol consumption is a leading cause of liver disease and liver-related death worldwide. Alcoholic liver disease includes, hepatic steatosis, steatohepatitis and ultimately fibrosis and cirrhosis. Emerging evidence has established the important role of the “gut-liver” axis in the development of alcoholic liver disease (ALD). Our recent work indicated that chronic alcohol induced perturbations in the gut microbiome and consequent changes in fatty acids have a major impact on the development of intestinal barrier dysfunction and ALD. The aim of this study was to investigate whether treatment with tributyrin - a butyrate prodrug results in protection against ALD in terms …
A Comparative Study Of Faecal Sludge Management In Malawi And Zambia: Status, Challenges And Opportunities In Pit Latrine Emptying, Rochelle Holm, James Madalitso Tembo, Bernard Thole
A Comparative Study Of Faecal Sludge Management In Malawi And Zambia: Status, Challenges And Opportunities In Pit Latrine Emptying, Rochelle Holm, James Madalitso Tembo, Bernard Thole
Faculty and Staff Scholarship
This review paper covers the issues of pit latrine emptying national policies and regulations with a focus on Malawi and Zambia. With 2.4 billion people worldwide still lacking improved sanitation facilities, developing countries need to look at policy, regulation and practice for household sanitation service provision with a new lens. What happens “next,” when improved sanitation facilities eventually become full? An emphasis on faecal sludge management has multiplied this important issue in the past few years. The authors compare the pit latrine emptying situation in Malawi and Zambia with a focus on status, challenges and opportunities. To build this comparison, …
Evaluating The Effects Of Aroclor 1260 In Non-Alcoholic Fatty Liver Disease : The Role Of Xenobiotic Receptors., Banrida Wahlang
Evaluating The Effects Of Aroclor 1260 In Non-Alcoholic Fatty Liver Disease : The Role Of Xenobiotic Receptors., Banrida Wahlang
Electronic Theses and Dissertations
Polychlorinated biphenyls (PCBs) are persistent environmental toxicants, present in 100% of US adults and dose-dependently associated with nonalcoholic fatty liver disease (NAFLD) in epidemiologic studies. PCBs are predicted to interact with receptors previously implicated in xenobiotic/energy metabolism and NAFLD. These receptors include the aryl hydrocarbon receptor (AhR), pregnane xenobiotic receptor (PXR), constitutive androstane receptor (CAR), peroxisome proliferator-activated receptors (PPARs), liver-X-receptor and farnesoid-X-receptor. This study evaluated the hepatic effects of the PCB mixture, Aroclor 1260, whose composition mimics human bioaccumulation patterns, in a mouse model of diet-induced obesity. Male C57Bl/6J mice were fed a control or 42% high fat diet (HFD) …
Identification Of The Potential Opportunities, Barriers, And Threats Within The Sector In Taking Up Sanitation As A Business: Rural Sanitation In Nkhata Bay District (Malawi)., Rochelle Holm, Elijah Wanda, Victor Kasulo, Simeon Gwayi
Identification Of The Potential Opportunities, Barriers, And Threats Within The Sector In Taking Up Sanitation As A Business: Rural Sanitation In Nkhata Bay District (Malawi)., Rochelle Holm, Elijah Wanda, Victor Kasulo, Simeon Gwayi
Faculty and Staff Scholarship
Private sector participation in sanitation marketing provides a great opportunity to improve rural sanitation access. Although a number of opportunities for private sector participation within the sanitation sector exist, there are numerous barriers and threats to taking up sanitation as a business. This Note from the Field identifies these opportunities, barriers, and threats in Nkhata Bay District, a rural area of Malawi. These insights emerge from a wider research project entitled 'Private sector participation in the delivery of sanitation and hygiene services'. This note provides background information on the research project on private sector participation and the project location. It …