Pharmacology, Toxicology and Environmental Health Commons^™

Variation Of Active Constituents Of Curcuma Domestica Rhizomes At Different Ages(การเปลี่ยนแปลงปริมาณสารสำคัญของขมิ้นชัน ในระยะเวลาเก็บเกี่..., Pranee Chavalittumrong, Warunee Jirawattanapong

The Thai Journal of Pharmaceutical Sciences

Rhizomes of Curcuma domestica Valeton at different ages were collected from Nakorn Pathom and Prachuap Khiri Khan provinces. The quantities of the active constituents, curcuminoids and volotile oil, of the rhizomes were determined. It was found that rhiz...

Inhibitory Effects Of Some 8-Prenylflavones Isolated From Tephrosia Apollinea On Platelet Aggregation (ผลของการยับยั้งการจับตัวของเกล็ดเลือดของ 8- พรีนีลฟลา..., Osama B. Abdel-Halim, Fumio Ikegami, Ahmed F., Hosny Abdel-Fattah, Jiro Arita, Yuichi Fujii, Toshikazu Sekine, Isamu Murakoshi

The Thai Journal of Pharmaceutical Sciences

7-Oxygenated-8-prenylflavones, (-)-semiglabrin (1), (+)-glabratephrin (2), (+)-glabratephrinol (3), (-)- pseudosemiglabrin (4) and (-)-pseudosemiglabrinol (5), were isolated from the aerial parts ofTephrosia apollinea (Leguminosae). Among these compounds...

Jsps-Nrct Core University System, Pharmaceutical Sciences, First Joint Seminar, Advance In Research On Pharmacologically Active Substances From Natural Sources, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cocaine And Timing: Drug Effects Under A Mixed Fixed-Interval Extinction Schedule, Vincent O. Hodge

Masters Theses

The effects of cocaine hydrochloride (3.2-56.2 mg/kg) were determined in rats performing under a mixed fixed-interval 60-seconds extinction 120-seconds schedule of food delivery. Responses were recorded in successive 5-second bins. With the exception of the highest dose (56.2 mg/kg), cocaine did not significantly affect rate of responding under the fixed-interval component or extinction component, or the time of peak responding under the extinction component. The highest dose significantly reduced response rates and shifted the time of peak responding leftward to quicker and earlier moments. Results are discussed in terms of possible rate- and time-dependent effects of stimulant drugs.

Effects Of Phenobarbital In Combination With Phenytoin Or Valproic Acid On The Delayed-Matching-To-Sample Performance Of Pigeons, Catherine Ann Karas

Masters Theses

The present study examined the effects of phenobarbital (S, 10,20, and 40 mg/kg), phenytoin (2.5, 5, 7.5, and 15 mg/kg), and valproic acid (40, 60, 80, and 120 mg/kg), and those of phenobarbital (10 and 20 mg/kg) in combination with phenytoin (2.5,5, and 7.5 mg/kg) or valproic acid (40, 60, and 80 mg/kg), on the delayed-matching-to-sample performance of pigeons. In general, high doses of each individual drug reduced accuracy. Drug combinations also reduced accuracy relative to control values. Reductions in accuracy produced by drug combinations were very similar in magnitude to those predicted by a response-addition model of drug interaction.

A Biochemical Study Of Gossypol And Lactate Dehydrogenase X Binary Interactions, Patricia Brown Ravenell

Theses and Dissertations in Biomedical Sciences

The goal of this project was to study the mechanism of action of gossypol through its (a) binary interaction with native and trypsin digested lactate dehydrogenase-X (LD-X), a sperm-specific isozyme, and (b) its binding in vitro in primary cultures of spermatogenic cells. Mouse LD-X was cleaved with trypsin before and after treatment with gossypol. This was followed by high performance chromatography (HPLC) separation of the LD-X tryptic peptide fragments to observed alterations in separation patterns as indicators of intramolecular disturbance in the enzyme molecule. Definite alterations in peptide fragment peaks were observed in the presence of gossypol and suggest conformational …

Evidence For The Elevation Of Serum Carcinoembryonic Antigen And Tumor-Associated Glycoprotein-72 Levels In Patients Administered Interferons, John Greiner, Fiorella Guadagni, David Goldstein, Ernest Borden, Roy Ritts, Patricia Witt, Albert Lobuglio, Mansoor Saleh, Jeffrey Schlom

Haematology and Oncology, East Africa

Sera were collected from 111 patients diagnosed with adenocarcinoma or nonadenocarcinoma malignancies who received different schedules of interferon (IFN)-γ or IFN-βser alone or in combination. Serum carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72) antigen levels were measured to determine whether interferon could enhance the tumor shedding and, thereby, the serum level of either tumor antigen. Less than 10% of the sera samples from patients diagnosed with nonadenocarcinoma malignancies (e.g., hairy cell leukemia, melanoma) had positive titers of TAG-72 or CEA, and interferon neither increased nor resulted in the appearance of either tumor antigen in those sera. In contrast, 59.2% and …

Pharmacokinetics, Immune Response, And Biodistribution Of Iodine-131-Labeled Chimeric Mouse/Human Igg1, K 17-1a Monoclonal Antibody, Ruby Meredith, Albert Lobuglio, Walter Plott, Roger Orr, Ivan Brezovich, Charles Russell, Elizabeth Harvey, Michael Yester, Mansoor Saleh

Haematology and Oncology, East Africa

Pharmacokinetics,immunogenicity,and biodistributionof a 131I-Iabeledmouse/human chimenc monoclonal antibody (C17-1A) was studiedin six metastaticcoloncancerpatients. Pharmacokinetics obtalned from serum radioactivity or chi mera concentration were identical after 5 mCi of 131I(>17-1A withmeanalphahalf-livesof 17.6±2.3 and19.7±2.9 and meanbeta half-livesof 100.9±16.1 and 106.4±14.1 hr, respectively. HPLC analysis documented the monomeric chi rneiic17-lA withoutevidenceof immunecomplexesorfree 1311 None of the patients developed antibody after ‘31I-chi merle17-1A exposure.Radiolocalizationoccurredin known areas of disease >4 cm in all patients. The half-life of total body radioactivity was 58 ±7 hr by whole-body counts and 64 ±13 hr by urine measurements. Whole-body and bone marrow dose estimates ranged from 0.75-1 .03 and …

Pharmacokinetics And Effects On Blood Chemistry Of Cyclosporine In Human Infants And Kid Goats, Floyd A. Beierle

Loma Linda University Electronic Theses, Dissertations & Projects

Kid goats (newborn) have been used in transplantation protocols to study the techniques and problems of infant human cardiac transplantation. Immunosuppression has been by cyclosporine in both species. However, the pharmacokinetics of cyclosporine (CSA) in both the kid goat and human infant were unknown. Therefore, the pharmacokinetics of CSA were investigated. A single dose study and a long term chronic administration study were undertaken in the goat. Six Nubian goats, ages 60-90 days, were given a single IV dose of CSA, 0.25 mg/kg, over a 10 minute period and 72 hr later an oral cyclosporine dose of 20 mg/kg. The …

Molecular Mechanisms Of Physalia Physalis Venom Modulation Of Cardiac And Vascular Functions, Eva Luo

Loma Linda University Electronic Theses, Dissertations & Projects

Portuguese man-of-war (Physalia physalis)venom has profound effects on the cardiovascular system of man and animals. The venom produces vascular relaxation in norepinephrine precontracted, intact rabbit femoral arterial rings by stimulating vasodilatory prostaglandin synthesis in the endothelium. This action does not depend on endotheliumderived relaxing factor (EDRF). P. physalis venom produces a vascular constriction on KC1 depolarized, intact rings. This is completely inhibited by dibenzyline and yohimbine. Increased membrane permeability to calcium may be involved in direct vascular smooth muscle stimulation. The venom has a positive inotropic effect on rat atrial preparations, which is intensified by increased extracellular calcium concentration. …

Trace Element Studies On Karachi Populations Part V: Blood Lead Levels In Normal Healthy Adults And Grammar School Children, W W. Manser, R Lalani, S Haider, M A. Khan

Department of Biological & Biomedical Sciences

Blood lead levels of healthy Karachi population were estimated. Mean levels for males, females, soldiers and school children were 34.4, 31.8, 29.9 and 38.2 micrograms/dl respectively. About 93% cases of either sex had elevated lead levels, of whom 30% males and 10% females had levels above the safety limits (40 micrograms/dl). Soldiers living in relatively pollution free area though had levels lower than the rest of the population but 91% had levels over 25 micrograms/dl and only two had acceptable levels. Ninety-two percent children showed levels above 25 micrograms/dl with a large number having levels over 40 micrograms/dl. A very …

Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi

Electronic Theses and Dissertations

Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i.p.), or a …

Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi

Electronic Theses and Dissertations

Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i.p.), or a …

Pathophysiology Of Hemorrhagic Shock And The Protective Effects Of Antioxidants, Annette Elizabeth Fleckenstein

Masters Theses

Considerable attention has focused on the role of free radicals in the pathophysiology of hemorrhagic shock. In this study, four pharmacological mechanisms for antagonizing free radical generation or reactions were compared in terms of their efficacy in attenuating post-hemorrhage (post-reinfusion) cardiovascular collapse. These included blocking arachidonic acid oxidation by cyclooxygenase (eg; ibuprofen), inhibiting superoxide radical production by xanthine oxidase (eg; oxypurinol), chelating iron (eg; desferal), and inhibiting lipid peroxidation (eg; U74006F and U78517G, Upjohn Company, Kalamazoo, Michigan).

Cardiovascular function, cerebral blood flow, arterial blood gases, serum glucose, and plasma vitamin E were examined in a hemorrhage/reperfusion model using urethane-anesthetized rats. …

Quantitative Determination Of Weak Acidic Drugs By Gran's Method(การหาปริมาณตัวยาที่เป็นกรดอ่อนโดยวิธีของแกรน), M. Pathipvanich, S. Rujirawat, S. Arttamangkul

The Thai Journal of Pharmaceutical Sciences

End point volume determinations by Gran's method were shown to be as accurate and reproducible as that of the reference nonaqueous titration methods which are described in the USP XXI. Gran's method gave satisfactory results even in cases which the union...

Quantitative Determination Of Weak Acidic Drugs In Mixed Solvents Using Gran's Method(การหาปริมาณตัวยาที่เป็นกรดอ่อนด้วยวิธีของแกรน ในตัวทำละล..., M. Pathipvanich, S. Rujirawat, J. Sukbuntherng

The Thai Journal of Pharmaceutical Sciences

Gran's method for determination of end point of potentiometric titration was extended to mixed organic/ aqueous solvent systems. In general, the calculated percentage purities of the acidic drugs were statistically indifferent from that obtained with the...

อาการแพ้-Allergy, สุกัญญา เจษฏานนท์

The Thai Journal of Pharmaceutical Sciences

บทความนี้กล่าวถึงกลไกและรูปแบบต่างๆ ของการเกิดอาการแพ้ อาการสารที่หลั่งและองค์ประกอบทา...

เทคโนโลยีชีวภาพในประเทศไทยกับ การประยุกต์ในทางเภสัชกรรม, วันชัย ดีเอกนามกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การพัฒนายาลดความดันโลหิต, ณัฐพล เหล่าพูนพัฒน์, ชำนาญ ภัตรพานิช

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ยาใช้กับ Rheumatoid Arthritis, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

เป็นบทความเกี่ยวกับยาต่างๆ ที่ใช้รักษา rheumatoid arthritis ขนาดของยาที่ใช้ อาการไม่พึงประสงค์ (ไทยเภส...

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ศูนย์บริการเทคโนโลยีเภสัชอุตสาหกรรม, ประสาน ธรรมอุปกรณ์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บิดเทร็กซ์ สารขมสำหรับความปลอดภัย, ฉันทนา อารมย์ดี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ยาสำหรับการติดเชื้อไวรัส, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

เป็นข้อมูลเกียวกับการใช้ยาต้านไวรัส ได้แก่ acyclovir, amantadine hydrochloride, didanosine (dideoxyinosine), dideoxycytidine, foscamet, ganciclovir, interferon, ribavirin, ...

การเลือกใช้ยาลดโมเลสเตอรอล, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

เป็นบทความเกี่ยวกับการเลือกใช้ยาลดโฆเลสเตอรอลในเลือด ได้แก่ cholestyramine, colestipol,niacin, lovastatin, gemfibrozil, probucol, clofibra...

ยาใช้กับการติดเชื้อราภายใน, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

เป็นบทความเกี่ยวกับการเลือกใช้ยารักษาการติดเชื้อราภายใน ข้อบ่งใช้ ขนาดและวิธีการให้ยา ...

ประมวลบทดัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Activity Of Betel Leaf On Micro-Organism Causing Skin Diseases(ฤทธิ์ของสมุนไพรพลูต่อเชื้อจุลินทรีย์ ที่ทำให้เกิดโรคผิวหนัง), ลัดดาวัลย์ บุญรัตนกรกิจ, อิงอร ลันทรานนท์, สันติ ถุงสุวรรณ, สารี วิรุฬหผล, อรทิน ยิ่งยง, วิมลมาศ ลิปีพันธ์, ประนอม โพธิยานนท์, วรรณา ศิริประชัย

The Thai Journal of Pharmaceutical Sciences

Ether fraction of betel leaf extract could inhibit growth of some pathogenic bacteria ((3-hemolytic streptococcus Group A and Staphylococcus aureus) and some dermatophytes (Trichophyton mentagrophytes, Trichophyton rubrum and Epidermophyton floccosum). T...

การเลือกใช้ยาต้านจุลชีพเพื่อป้องกัน การติดเชี้อจากการผ่าตัด, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

บทความเกี่ยวกับการเลือกใช้ยาต้านจุลชีพเพื่อป้องกันการติดเชื้อในการผ่าตัด ที่เกี่ยวกับ ...

Ranitidine ทำให้เจ็บแน่นหน้าอก, สุกัญญา เจษฎานนท์

The Thai Journal of Pharmaceutical Sciences

หญิงอายุ 45 ปี ไม่เคยมีประวัติเป็นโรคเกี่ยวกับหัวใจมาก่อน เกิดมีอาการเจ็บแน่นหน้าอกถึงสอ...