Pharmacology, Toxicology and Environmental Health Commons^™

Bioequivaience Study Of Two Different Formulations Of 300 Mg Gabapentin Capsule In Thai Healthy Volunteers, Supeecha Wittayalertpanya, Sumana Chompootaweep, Nongnuch Thaworn, Wondee Khemsri, Nantana Intanil

The Thai Journal of Pharmaceutical Sciences

The objective of this study was to compare the bioavailability of new generic product of gabapentin with the innovator’s product. The study was performed in 20 Thai male healthy volunteers who received a single oral dose of 300 mg gabapentin capsule. D...

The Role Of National Science Journals: Information, Advocacy And Education, Alexander T. Florence

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

High-Performance Liquid Chromatographic Determination Of Asiatic Acid In Human Plasma, Phensri Thongnopnua

The Thai Journal of Pharmaceutical Sciences

Asiatic acid, an active metabolite of asiaticoside, is one of the biological active triterpenoids in Centella asiatica. A single liquid-liquid extraction and high-performance liquid chromatographic (HPLC) method have been developed and validated for the ...

Spectrophotometric Determination Of Total Alkaloids In Some Iranian Medicinal Plants, Fazel Shamsa, Hamidreza Monsef, Rouhollah Ghamooshi, Mohammadreza Verdian-Rizi

The Thai Journal of Pharmaceutical Sciences

A simple spectrophotometric method based on the reaction with bromocresol green (BCG) has been developed for determination of total alkaloids in medicinal plants. A yellow complex forms and is easily extractable by chloroform at pH 4.7. The absorbance of...

Antimicrobial Activity Of Endophytic Bacteria Isolated From Thai Medicinal Plant(ฤทธิ์ต้านจุลินทรีย์ของแบคทีเรียเอนโดไฟท์ที่แยกจากสมุนไพรไ..., Areerat Laorpaksa, Suree Jianmongkol, Wimon Pothiwong

The Thai Journal of Pharmaceutical Sciences

Endophytic bacteria were isolated from internal plant tissues within four days of collections using a surface disinfected method. One hundred and six isolates from thirty five of Thai medicinal plants were cultured in either nutrient broth or nutrient br...

Mixing And Formulation Of Low Dose Drugs : Underlying Problems And Solutions, Vipin Kukkar, Vikas Anand, Mahesh Kataria, Manoj Gera, Pratim Kumar Choudhury

The Thai Journal of Pharmaceutical Sciences

Mixing and formulation of low dose drugs can be very challenging due to problems related to segregation, content uniformity and physical stability. A careful control on these factors is necessary while manufacturing low dose drug products. Selection of e...

Stability Evaluation Of Celecoxib Nanoemulsion Containing Tween 80, F. Shakeel, S. Baboota, A. Ahuja, J. Ali, M.S. Faisal, S. Shafiq

The Thai Journal of Pharmaceutical Sciences

The aim of the present study was to evaluate the stability of celecoxib (CXB) using novel nanoemulsion formulation. Optimized nanoemulsion formulation of CXB was prepared by low energy emulsification method, stability studies were performed for the perio...

Preparation And Stability Of Butterfly Pea Color Extract Loaded In Microparticles Prepared By Spray Drying, Angkana Tantituvanont, Pornpen Werawatganone, Pacharaporn Jiamchaisri, Kasorn Manopakdee

The Thai Journal of Pharmaceutical Sciences

Butterfly pea is one of the most interesting sources of natural color used in food and cosmetics. Anthocyanins are the main coloring compounds in its petals and could be extracted easily with water. The pH of medium, temperature, and light were found to ...

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fast-Disintegrating Aceclofenac Tablets: Formulation Development Using Simplex Lattice, Garala Kevin C., Ekshinge Vinit, Jarag Ravindra, Shinde Anil J.

The Thai Journal of Pharmaceutical Sciences

The poor aqueous solubility of the drug results เท variable dissolution profile and hence poor bioavailability. The aim of present work was to show the effect of various super disintegrants on the disintegration time and in vitro drug release rate. ...

The Metastasis Suppressor Nm23-H1 Is Required For Dna Repair, Mengmeng Yang

University of Kentucky Doctoral Dissertations

NM23-H1 represents the first identified metastasis suppressor, exhibiting reduced expression in breast carcinoma and melanoma, and an ability to inhibit metastatic growth without significant impact on the transformed phenotype. Although its molecular mechanism of action is not fully understood, NM23-H1 possesses at least three enzymatic activities that may mediate metastasis suppressor function. It catalyzes nucleoside diphosphate kinase (NDPK) activity, as well as protein histidine kinase and 3’-5’ exonuclease activities. As 3’-5’ exonucleases are generally required for maintenance of genomic integrity, this activity represents a plausible mediator to underlie the metastasis suppressor function of NM23-H1 protein. To investigate the relevant activity …

Layer -By -Layer Self -Assembly Of Micro-Capsules For The Magnetic Activation Of Semi-Permeable Nano-Shells, Malcolm D. Prouty

Doctoral Dissertations

Layer-by-layer (LbL) self-assembly has demonstrated broad perspectives for encapsulating, and the controllable delivery, of drugs. The nano-scale polymer layers have the capability of material protection. Magnetic nanoparticles have great potential to be applied with LbL technology to achieve both "focusing" of the encapsulated drugs to a specific location followed by "switching" them on to release the encapsulated drugs. In this work, Phor21-βCG(ala), dextran, and dexamethasone were used as model drugs. Encapsulation of these drugs with layer-by-layer self-assembly formed biolnano robotic capsules for controlled delivery and drug release.

Silica nanoparticles coated with polyelectrolyte layers of sodium carboxymethyl cellulose (CMC) or gelatin …

Maturational Changes In Cerebrovascular Thick- And Thin-Filament Regulation, Renan Joel Sandoval

Loma Linda University Electronic Theses, Dissertations & Projects

The present study focused on the main hypothesis that age-related changes in myofilament Ca²⁺ sensitivity involve simultaneous changes in the relations between cytosolic Ca²⁺ transients, myosin phosphorylation, and force development. To define the effects of late fetal and early postnatal maturation, parallel experiments were carried out using cerebral arteries from both term lamb fetuses (140-141 days of gestation) and nonpregnant adult sheep. Fetal and adult cerebral arteries were stimulated by either mechanically, electromechanically, and/or pharmacomechanically-induced contractions, and the relations of cytosolic Ca²⁺, MLC phosphorylation, and contractile tensions were measured. These measurements allowed for stimulus and age-dependent …

Immunoadjuvanticity Of Chlorophyll, Jocelyn Helen Parks Ramos

All-Inclusive List of Electronic Theses and Dissertations

Background: Vaccines are formulations containing antigenic determinants (from non-self organic matters) and immuno-enhancers called adjuvants. Together, they evoke protective immune responses in hosts. Adjuvants are substances that further vaccines' capability to induce a robust immune response. Common side effects with conventional adjuvants used in most vaccines are toxicity, inflammation and granulomas. In this study we investigated the pigment chlorophyll (Chl) for immunoadjuvanticity. The selection of chlorophyll is based on the fact that it is a component in foods such as spinach, and that it contains an isoprenoid structure that is a feature of many conventional adjuvants, Pristane and Squalene. Chl …

Regulation Of Alpha-1-Adrenoceptor-Mediated Contractions Of The Uterine Artery By Pkc, Hongying Zhang

Loma Linda University Electronic Theses, Dissertations & Projects

Pregnancy is associated with a significant decrease in uterine vascular tone and a striking increase in uterine blood flow, which ensures normal fetal development. Multiple mechanisms are involved in the adaptation of uterine artery contractility during pregnancy. Both protein kinase C (PKC) and activation of ai-adrenoceptors play important roles in the regulation of uterine artery contractility. In addition, PKC mediates the pregnancyassociated decrease in myogenic tone of the uterine artery, and interacts with ajadrenoceptors leading to modulation of ai-adrenoceptor-mediated contractions of vascular smooth muscle. Yet, whether or to what extent PKC regulates ai-adrenoceptormediated contractions of the uterine artery and their …

Drug Loading And Release From Polypeptide Multilayer Nanofilms, Yang Zhong

Doctoral Dissertations

Polypeptides, linear macromolecules, are formed from amino acid residues by linkage of peptide bonds. Proteins are polypeptides too, with more complex conformations contributing to specific functionalities. Disulfide bonds are very important to maintain the structure and functions of proteins, which will form between two cysteine (Cys) residues under oxidizing circumstance.

Cys containing polypeptides are designed and synthesized by F-moc (9-Fluorenylmethyloxycarbonyl) chemistry. The number and position of Cys residues can be controlled by amino acid sequences design and following peptide synthesis, which is important to gain insights on the nature of polyelectrolyte multilayer film assembly and stability.

Both commercial and designed …

Chemometrics-Assisted Spectrophotometric Determination Of Certain Β-Lactam Antibiotics Combinations, Abd El-Maboud I. Mohamed, Hesham Salem, Eman Maher

The Thai Journal of Pharmaceutical Sciences

Multivariate and derivative spectrophotometric techniques (first derivative and derivative ratio) were developed for the determination of four p-lactam antibiotic binary mixtures; ampicillin with flucloxacillin (mix I), ampicillin with dicloxacillin (mix...

Effects Of Drying Temperature And Residual Moisture Content Of Fa-Tha-Li (Andrographis Paniculata (Burm.F.) Nees) Crude Powder For Capsule Preparation, Wipawee Saohin, Preecha Boonchoong, Supachai Lamlikitkuakoon, Itthichai Jamnoiprom, Wittaya Mungdee

The Thai Journal of Pharmaceutical Sciences

The objectives of this research were to study the effects of drying temperature and residual moisture content on total lactones content calculated as andrographolide, flow ability and microbial contamination of Fa-Tha-Li (Andrographis paniculata (Burm.f....

Characterization Of Herpes Simplex Virus Type 1 Selected In Culture For Resistance To Acyclovir Or Foscarnet, Mali Wirotesangthong, Sakulrat Rattanakiat, Katsuhiko Matsui, Vimolmas Lipipun

The Thai Journal of Pharmaceutical Sciences

To determine the characteristics of herpes simplex virus type 1 (HSV-1) resistant to either acyclovir (ACV) or foscarnet (FOS), HSV-1 KOS (wild-type) strain was used for selection of drug-resistant mutants in Vero cells. เท one-step growth curve, all...

An Approach To Developing Dissolution Standards For Turmeric Capsules I: Basket Rotating Method, Nantana Sittichai, Sirichai Krabesri, Ekamol Suthison, Parkpoom Tengamnuay

The Thai Journal of Pharmaceutical Sciences

A simple dissolution test and standard was developed for Turmeric capsules to replace the less discriminating disintegration test stated in the Supplement to Thai Herbal Pharmacopoeia 2004. The proposed test used the basket at 100 rpm and the dissolution...

Comparative Analysis Of Pharmaceutical Care And Traditional Dispensing Role Of Pharmacy, Phantipa Sakthong

The Thai Journal of Pharmaceutical Sciences

Pharmaceutical care is a new professional practice that can give an opportunity to pharmacists to prove themselves as a real health care profession. Pharmaceutical care practitioners are concerned with the outcomes of their services on patients’ life a...

Use Of A Dialyzable Short-Chain Phospholipid For Efficient Preparation Of Virosome Vaccines Against Newcastle Disease, Atthachai Homhuan, Sompol Prakongpan

The Thai Journal of Pharmaceutical Sciences

Virosomes can be regarded as liposomes carrying the spike proteins of enveloped virus on their surface. To further advance the use of virosomes, we developed a solubilization/ reconstitution procedure for construction of Newcastle disease (ND)-virosomes,...

28-Day Repeated Dose Oral Toxicity Study Of Litsea Cubeba Essential Oil In Sprague-Dawley Rats, Siraprapa Tubtim, Ake Wasiksiri

The Thai Journal of Pharmaceutical Sciences

Litsea cubeba essential oil is a raw material source for the isolation of citral that can be converted to a number of important derivatives. This citral-rich essential oil is also increasingly used for flavour and fragrance applications in many household...

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Triterpenoids From The Stem Of Diospyros Glandulosa, Witchuda Thanakijcharoenpath, Orawan Theanphong

The Thai Journal of Pharmaceutical Sciences

Six pentacyclic triterpenoids, including friedelin, β-amyrin, oleanolic acid, lupeol, betulin and ursolic acid, have been isolated from the stem of Diospyros glandulosa Lace. Identification of the isolated compounds was accomplished by analysis of their...

Hplc Determination Of Active Diterpene Lactones From Andrographis Paniculata Nees Planted In Various Seasons And Regions In Thailand, Chamnan Patarapanich, Suwanna Laungcholatan, Nuntakan Mahaverawat, Chaiyo Chaichantipayuth, Sunibhond Pummangura

The Thai Journal of Pharmaceutical Sciences

A quantitative determination of four known diterpene lactone compounds : dehydroandroghapholide (C-2), andrographolide (C-3), neoandrographolide (C-4) and deoxyandrographolide-19-p-D glucoside (C-5) from the leaves of Andrographis paniculata, Nees. has b...

Samambaia - The Future Focus For Indian Researchers In The Treatment Of Psoriasis, Kuntal Das, John Wiiking Einstein

The Thai Journal of Pharmaceutical Sciences

Psoriasis is an issue of global and national public health concern. The traditional use of medicinal plants to treat this disease is widespread throughout India. The present review is an attempt for the beneficial effect of the South American originated ...

Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe

Biological Sciences Faculty Publications

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobolograrn analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …

Microparticulate Drug Reformulation Using Electrostatic Layer -By -Layer Assembly And Co-Entrapment With Anionic Phospholipids In Calcium Carbonate Matrix, Krishna Gopal

Doctoral Dissertations

Non-invasive drug delivery systems for therapeutic drugs are gaining prominence. One such system, the nasal delivery system, shows good prospect for effective delivery of some drugs, however, it is yet to be well established for others. The preparation of a reformulated drug and studying its in vitro characteristics is a crucial step in the process of adapting the new drug for nasal delivery systems. The purpose of this research is to study the effect of electrostatic layer by layer assembly of polyelectrolytes on PROMAXX®insulin microparticles and to study the chemical, physical and corresponding release properties of the resulting formulations. PROMAXX® …

Previous Spatial Memory Training And Nicotine Administration Alleviates Cognitive Deficits Produced By Medial Frontal Cortex Lesions In Rats., Rachel L. Norris

Electronic Theses and Dissertations

Rats were administered nicotine (0.3 mg/kg) for 11 consecutive days before and after an electrolytic medial frontal cortex lesion. Behavioral testing was arranged so that the rats were tested on the RAM 1 day after drug administration followed by behavioral testing on the MWT 19 days after drug treatment, or tested on the MWT 1 day after drug administration followed by testing on the RAM4 days after drug treatment. Results of MWT testing showed that regardless of the drug/behavioral testing interval, lesioned rats given nicotine demonstrated enhancement relative to saline-treated animals. Results of RAM testing showed that nicotine improved performance …