Pharmacology, Toxicology and Environmental Health Commons^™

Predicting The Development Of Renal Impairment In Type 2 Diabetic Patients With Preserved Kidney Function, Suchada Kittipanyaworakun, Chaowarat Munpronr, Titinun Auamnoy, Kearkiat Praditpornsilpa, Somratai Vadcharavivad

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Production Of Halal Herbal Medicinal Products In Chanae Hospital: A Community Hospital In Narathiwas Province, Thailand, Chaowalit Monton, Krisana Kraisintu, Natawat Chankana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Bactericidal Proteins Of Skin Mucus And Skin Extracts From Fresh Water Fishes, Clarias Batrachus And Tilapia Mossambicus, Krishnamoorthy Elavarasi, Shanmugavel Ranjini, Thangavel Rajagopal, Ganesan Rameshkumar, Ponnirul Ponmanickam

The Thai Journal of Pharmaceutical Sciences

Fish skin mucus plays a major role in protection against invading pathogens. The present study was aimed to evaluate the bactericidal activity of skin mucus and skin extracts of two freshwater fishes, Clarias batrachus and Tilapia mossambicus. Fish skin ...

Highly Efficient Preparation Of Ethyl Piperate From Piperine Isolated From Piper Nigrum, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Discovery Of Novel Cholinesterase Inhibitor (Rknu026) With P-Amyloid Aggregation Inhibitory Activity, Thippatai Hiranyaekaphap, Nitipol Srimongkolpithak, Thamrong Wongchang, Prayuth Poowaruttanawiwat, Kwanchai Rattanamanee, Ruengwit Kitbunnadaj

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Preparation Of 2'-N-2,3,4-Trifluorobenzoyl Derivative Of Cytotoxic Ecteinascidin 770 From The Thai Tunicate Ecteinascidia Thurstoni, Witaya Lowtangkitcharoen, Taksina Chuanasa, Naoki Saito, Khanit Suwanborirux

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Extraction Of Oil From Grape Seeds With Supercritical Carbon Dioxide, Jirawat Eiamwat, Paramee Pengpreecha, Benjaporn Tiensong, Sorada Walapa, Kulapatr Wachirasiri, Sukit Kampruengdet

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Stingless Bee Honey Ii: Qualitative And Quantitative Studies On Honey Produced By Three Stingless Bee Species Collected From A Mangosteen Garden In Chantaburi Province, Thailand, Nipatha Issaro, Thorsang Weerakul, Sisipawan Machana, Phatsakorn Ornnim, Chamipha Phanudulkitti, Tharathee Srijan, Jiratikron Laiwattanaphaisal, Chumnan Pattarapanich

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Acute Oral Toxicity Test Of Quercusinfectoria G. Olivier Extract In Rats, Tuanta Sematong, Sirinan Thubthimthed, Sareeya Reungpathanapong, Sarunya Laovitthayanggoon, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Synergy Effect Of Ceftazidime With Flavonoids Against Streptococcus Pyogenes, Supatcharee Siriwong, Pongrit Krubphachaya, Kanjana Thumanu, Griangsak Eumkeb

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Effects Of Red Kwao Krue (Butea Superba Roxb.) Extract On Sperm Quality And Testosterone Level In Mice, Griangsak Eumkeb, Wanatkamol Naknarong, Kittipot Sirichaiwetchakoon

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development And Validation Of Rp-Hplc Method For Quantitative Analysis Of Individual Y-Oryzanol In Cold Pressed Rice Bran Oil, Apirak Sakunpak, Jirapornchai Suksaeree, Laksana Charoenchai, Chaowalit Monton, Pathamapom Pathompak, Tossaton Charoonratana, Krisana Kraisintu

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Quantification And Validation Of Gallic Acid Content In Tri-Phala Extract And Effervescent Tablet By Hptlc, Beniapom Chainethvanich., Worawan Saingam, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development And Validation Of Rp-Hplc Method For Determination Of Piperine In Maha-Solos Tablet Formulation, Worawan Saingam, Chaowalit Monton, Jirapornchai Suksaeree, Natawat Chankana, Siriporn Kittiwisut, Laksana Charoenchai

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Shampoo Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limonella For Itchy Scalp, Buppachart Potduang, Itsara Keeta, Suchipha Wannaphatchaiyong, Wanlapha Saisin, Bundit Fungsin

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Jatu-Phalathika Formulation In Effervescent Tablet Dosage Form, Pongsak Awaivawanon, Anchana Sanrungmuang, Worawan Saingam, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Miscibility Study Of Benzocaine And Poly L-Lactide Using Solubility Parameter Calculation And Thermal Analysis, Yada Vattanagiivingyong, Narueporn Sutanthavibul, Jittima Chatchawalsaisin

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Lawsone Methyl Ether Loaded Chitosan-Dextran Sulfate Nanoparticles; Preliminary Study, Pattravee Niamprem, Pharkphoom Panichayupakaranant, Waree Tiyaboonchai

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fabrication And Evaluation Of Clotrimazole-Loaded Pvp/Hppcd Nanofiber Mats For Oral Candidiasis, Prasopchai Tonglairoum, Tanasait Ngawhirunpat, Theerasak Rojanarata, Ruchadaporn Kaomongkolgit, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Perspectives On Ethanol Toxicity In Medaka Embryogenesis And Possible Protection By Asian Ginseng (Panax Ginseng): Histological And Biochemical Analysis, Mona Hamdi Haron

Electronic Theses and Dissertations

Alcohol is recognized as a classic teratogen capable of inducing a wide range of developmental abnormalities. Alcohol consumption during pregnancy may produce permanent brain damage in the fetus and is associated with the development of a life-long behavioral, social, and cognitive disorder now known as fetal alcohol spectrum disorder (FASD). The most clinically recognizable form of FASD is fetal alcohol syndrome (FAS) which is characterized by specific features including facial dysmorphogenesis, mental dysfunction, growth retardation, and cardiovascular and limb defects. Due to ethical constraints, human studies of FASD are very limited. Therefore our current understanding of FASD is mainly based …

Function And Regulation Of Intestinal P450 Enzymes : Insights From Conditional Cytochrome P450 Reductase Knockout Mouse Models, Yi Zhu

Legacy Theses & Dissertations (2009 - 2024)

The overall goal of this thesis work was to investigate the function and regulation of intestinal P450 enzymes (P450s). The central hypotheses are that 1) small intestinal (SI) P450s play an important role in the first-pass clearance of oral drugs and in bioactivation of chemicals that cause intestinal toxicity, 2) endogenous regulatory compounds produced by intestinal P450s are important for protection against chemical-induced colon inflammation, and 3) there is a cross talk between the liver and the SI that helps to maintain the overall xenobiotic-metabolism capacity of the digestive tract.

Role Of P450 Enzymes In Tobacco Dependence And Lung Tumorigenesis, Lei Li

Legacy Theses & Dissertations (2009 - 2024)

The overall aim of this study is to better define the roles of P450 enzymes, particularly those in the CYP2A, 2B, and 2F gene subfamilies, in the metabolism and actions of tobacco-related chemicals. Tobacco smoke contains numerous compounds that are deleterious to health, including the primary addictive component nicotine and procarcinogenic compounds, such as naphthalene (NA) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Our main hypotheses are i) that CYP2A and 2B enzymes are largely responsible for nicotine metabolism, and they can impact nicotine dependence; and ii) that CYP2A, 2B, and 2F enzymes play important and tissue-specific roles in NA and NNK bioactivation, leading …

The Effect Of Alpha-Cyclodextrin On Acute Blood Lipid And Glycemic Responses To A Fat Containg Meal, Evan Neil Fletcher

Wayne State University Theses

Obesity and hyperlipidemia have become major concerns in the United States over the past 30 years. Alpha-Cyclodextrin (á-CD), a naturally occurring soluble dietary fiber, has been shown to reduce dietary fat absorption and improve blood lipid levels in an animal model (mouse and rat) and in human studies. In the current double blind study, 34 healthy male and female participants were recruited to test if á-CD had any acute effect on blood lipid and glycemic responses to a fat containing meal. The participants received the á-CD on one occasion and a placebo the other to determine if there was any …

Does The Use Of Varenicline For Smoking-Cessation Therapy Create Or Increase Depression In Patients Without Existing Depressive Illness?, Brett R. Brown

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of varenicline for smoking-cessation therapy creates or increases depression in patients without existing depressive illness.

STUDY DESIGN: Review of two randomized controlled trials published in 2011 and one observational cohort study published in 2009, all English language.
DATA SOURCES: Two randomized, double-blind, controlled clinical trials comparing varenicline to placebo in smoking cessation, and one observational cohort study comparing varenicline use within subjects. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: Changes in depression was evaluated using the MontgomeryÅsberg Depression Rating Scale …

Study Of Charge-Dependent Transport And Toxicity Of Peptide-Functionalized Silver Nanoparticles Using Zebrafish Embryos And Single Nanoparticle Plasmonic Spectroscopy, Kerry J. Lee, Lauren M. Browning, Prakash D. Nallathamby, Xiao-Hong Nancy Xu

Chemistry & Biochemistry Faculty Publications

Nanomaterials possess unusually high surface area-to-volume ratios and surface-determined physicochemical properties. It is essential to understand their surface-dependent toxicity in order to rationally design biocompatible nanomaterials for a wide variety of applications. In this study, we have functionalized the surfaces of silver nanoparticles (Ag NPs, 11.7 ±+2.7 nm in diameter) with three biocompatible peptides (CALNNK, CALNNS, CALNNE) to prepare positively (Ag-CALNNK NPs^+ζ), negatively (Ag-CALNNS NPs^−2ζ), and more negatively charged NPs (Ag-CALNNE NPs^−4ζ), respectively. Each peptide differs in a single amino acid at its C-terminus, which minimizes the effects of peptide sequences and serves as …

Molecular Mechanisms By Which C-Abl And Arg Mediate Melanoma Invasion And Metastasis, Sourik S. Ganguly

Theses and Dissertations--Pharmacology and Nutritional Sciences

Metastasis is one of the main causes of death in cancer patients. Metastatic melanoma is a death sentence, as chemotherapeutic agents have a 5% success rate or do not extend survival beyond 10 months. The lack of effective chemotherapeutic agents for treating metastatic melanoma indicates a dire need to identify new drug targets and develop new therapies. Our lab has previously shown that the kinase activity of Abelson family of non-receptor tyrosine kinases (c-Abl and Arg) is elevated in invasive breast cancer cell lines as compared to non-invasive cell lines. Previous studies from our lab have shown that Abl …

Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami

Theses and Dissertations--Pharmacy

Obesity and drug abuse share common neural circuitries including the mesocoticolimbic and striatal dopamine reward system. In the current study, a rat model of diet-induced obesity (DIO) was used to determine striatal dopamine function, impulsivity and motivation as neurobehavioral outcomes and predictors of obesity. For the outcome study, rats were randomly assigned a high-fat (HF) or a low-fat (LF) diet for 8 wk. Following the 8-wk HF-diet exposure, rats were segregated into obesity-prone and obesity-resistant groups based on maximum and minimum body weight gain, respectively, and neurobehavioral outcomes were evaluated. For the predictor study, neurobehavioral antecedents were evaluated prior to …

Regulation Of 7-Dehydrocholesterol Reductase By Vitamin D3, Ling Zou

Theses and Dissertations--Pharmacy

7-Dehydrocholesterol (7-DHC) is the substrate of 7-dehydrocholesterol reductase (DHCR7) in the cholesterol synthesis pathway. Keratinocytes in human skin possess the enzymes necessary for cholesterol synthesis but are also responsible for vitamin D₃ synthesis from 7-DHC by exposure to UVB irradiation. It has been well established that DHCR7 is regulated by the SREBP pathway in the regulation of cholesterol synthesis, but little is known about the regulation of DHCR7 by the vitamin D pathway. In this study, the regulation of DHCR7 activity by vitamin D was explored. Treatment of adult human epidermal keratinocyte (HEKa) cells with vitamin D₃ resulted …

Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar

Theses and Dissertations--Pharmacy

Effects of pharmacotherapies for Attention Deficit/Hyperactivity Disorder (ADHD) on cocaine abuse liability in ADHD are not understood. Spontaneously Hypertensive Rats (SHR), an ADHD model, exhibited greater cocaine self-administration than control Wistar-Kyoto and Wistar rats. Methylphenidate, but not atomoxetine during adolescence enhanced cocaine self-administration in adult SHRs compared to controls. The mesocortical dopaminergic system, including medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, is important for ADHD and cocaine addiction. Dopamine and norepinephrine transporter (DAT and NET) are molecular targets for methylphenidate, atomoxetine and cocaine action.

In the current studies, SHR, Wistar-Kyoto and Wistar were administered methylphenidate (1.5 mg/kg/day, p.o.), atomoxetine (0.3 …

Fine Tuning A Well-Oiled Machine: Influence Of Nk1.1 And Nkg2d On Nkt Cell Development And Function, Sunil K. Joshi, Mark L. Lang

Bioelectrics Publications

Natural killer T cells (NKT) represent a group of CD1d-restricted T-lineage cells that provide a functional interface between innate and adaptive immune responses in infectious disease, cancer, allergy and autoimmunity. There have been remarkable advances in understanding the molecular events that underpin NKT development in the thymus and in the complex array of functions in the periphery. Most functional studies have focused on activation of T cell antigen receptors expressed by NKT cells and their responses to CD1d presentation of glycolipid and related antigens. Receiving less attention has been several molecules that are hallmarks of Natural Killer (NK) cells, but …