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Articles 2131 - 2160 of 3590

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration, Rohit. H. Khatri, Rashmin. B. Patel, Mrunali R. Patel Jan 2014

A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration, Rohit. H. Khatri, Rashmin. B. Patel, Mrunali R. Patel

The Thai Journal of Pharmaceutical Sciences

This paper describes a validated high-performance liquid chromatographic (HPLC) method for simultaneous estimation of clindamycin (CLI) and adapalene (ADA) in pure powder and gel formulation. The HPLC separation was achieved on a Luna C18 (2) (250 x 4.6 ...

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Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring, Jareerut Kongrit, Yotin Chinvarun, Nuansri Niwattisaiwong, Somsong Lawanprasert Jan 2014

Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring, Jareerut Kongrit, Yotin Chinvarun, Nuansri Niwattisaiwong, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

This study aims to verify the correlation between serum and saliva topiramate concentrations in Thai patients with epilepsy. Twenty-six subjects were patients aged 17-56 years old who were under treatment with topiramate. Their blood and saliva samples w...

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Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis, Jankana Burana-Osot, Panadda Phattanawasin, Sununta Srisopon, Praveen Kumar Ashok, Baokang Huang, Uthai Sotanaphun Jan 2014

Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis, Jankana Burana-Osot, Panadda Phattanawasin, Sununta Srisopon, Praveen Kumar Ashok, Baokang Huang, Uthai Sotanaphun

The Thai Journal of Pharmaceutical Sciences

Kot-chula-lumpa is a crude drug of Thai traditional medicine for fever remedy. To authenticate its botanical origin, gas chromatogram of its non-polar constituents was analysed and compared with those of authentic samples by using chemometric tools. Fing...

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Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients, Salinthip Aphichartphunkawee, Yotin Chinvarun, Pornpimol Kijsanayotin Jan 2014

Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients, Salinthip Aphichartphunkawee, Yotin Chinvarun, Pornpimol Kijsanayotin

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to investigate the association of genetic variants in UGT1A6 19T>G, 541A>G and 552A>C together with non-genetic variant with VPA dose and plasma concentrations in Thai epileptic patients. Eighty four Thai epileptic patients who ...

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Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization, Anjan Kumar Mahapatra, Supriya Samoju, Ruchita Kumari Patra, Padala Narasimha Murthy Jan 2014

Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization, Anjan Kumar Mahapatra, Supriya Samoju, Ruchita Kumari Patra, Padala Narasimha Murthy

The Thai Journal of Pharmaceutical Sciences

The study was aimed to improve solubility or dissolution characteristics of dronedarone hydrochloride by preparing its inclusion complexes (ICs) with ß-cyclodextrin (ß-CD) and hydroxypropyl ß-cyclodextrin (HP ß-CD). The phase solubility behavior of d...

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Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul Jan 2014

Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul

The Thai Journal of Pharmaceutical Sciences

Ebola virus (EBOV) causes severe haemorrhagic fever in humans with high fatality rate up to 90 %. There is currently no approved drug or vaccine for human use. and treatment relies almost exclusively co supportive therapy. However, there are several pote...

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Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions, Isariya Techatanawat, Chutima Manamuti, Jaturavit Vattanarongkup, Polsak Teerawonganan, Ekawan Yoosakul, Wiwat Supasena, Bancha Chuasuwan, Piengthong Narakorn, Ponanee Puranaoti Jan 2014

Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions, Isariya Techatanawat, Chutima Manamuti, Jaturavit Vattanarongkup, Polsak Teerawonganan, Ekawan Yoosakul, Wiwat Supasena, Bancha Chuasuwan, Piengthong Narakorn, Ponanee Puranaoti

The Thai Journal of Pharmaceutical Sciences

Abacavir is an antiretroviral drug that can be prescribed in single dose or in fixed-dose combination formulations to make adherence easier. Due to this advantage, a generic product of abacavir of GPO has been developed with lower price and would be bene...

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Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami Jan 2014

Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami

The Thai Journal of Pharmaceutical Sciences

A simple, specific and robust stability indicating high performance liquid chromatographic (HPLC) method for estimation of bamifylline hydrochloride was developed and validated. Bamifylline hydrochloride was separated and quantitated on Inertsil ODS-3V c...

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Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert Jan 2014

Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Urine and blood samples are normally used to determine methamphetamine (MA) level in forensic and clinical toxicology for assessment of illicit MA use. In cases in which both samples are unavailable or contaminated, hair root has been proposed as an alte...

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Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat Jan 2014

Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat

The Thai Journal of Pharmaceutical Sciences

Tree-Phon-Thad remedy is used as an antipyretic and anti-inflammatory agent by traditional practitioners in Thailand, and includes roots of Zingiber zerumbet (Kra-Thue), Zingiber montamum (Plai) and Cymbopogon nadus (Ta-Krai-Hom). In this study, the anti...

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Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects, Kannikar Chatsantiprapa, Cameron Hurst, Kaewjai Thepsuthammarat, Nutcharee Thapunkaw, Wilaiwan Khrisanapant Jan 2014

Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects, Kannikar Chatsantiprapa, Cameron Hurst, Kaewjai Thepsuthammarat, Nutcharee Thapunkaw, Wilaiwan Khrisanapant

The Thai Journal of Pharmaceutical Sciences

To investigate if chili consumption as a food ingredient in a fried rice meal would have any real acute pharmacological effects on autonomic nervous system (ANS) and metabolic system (MS), a randomized, cross-over, intervention trial was conducted in 33 ...

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Short-Term Safety And Efficacy Of Fish-Oil Emulsions On The Prevention Of Parenteral Nutrition-Associated Liver Disease In Surgical Neonates: A Randomized Controlled Trial, Jrarat Ariyawangso, Chankit Puttilerpong, Suntaree Ratanachu-Ek, Maitree Anuntkosol Jan 2014

Short-Term Safety And Efficacy Of Fish-Oil Emulsions On The Prevention Of Parenteral Nutrition-Associated Liver Disease In Surgical Neonates: A Randomized Controlled Trial, Jrarat Ariyawangso, Chankit Puttilerpong, Suntaree Ratanachu-Ek, Maitree Anuntkosol

The Thai Journal of Pharmaceutical Sciences

Surgical neonates requiring prolonged parenteral nutrition (PN) are at risk for parenteral nutrition-associated liver disease (PNALD) that contributes to an increase in morbidity and mortality in surgical infants. Current lipid emulsions used with neonat...

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Evaluation Of Analgesic Activity Of Hydroalcoholic Extract Of Ipomoea Staphylina, Soumyadeep Ghosh, M Firdous Jan 2014

Evaluation Of Analgesic Activity Of Hydroalcoholic Extract Of Ipomoea Staphylina, Soumyadeep Ghosh, M Firdous

The Thai Journal of Pharmaceutical Sciences

This study has been attempted to evaluate analgesic property of hydroalcoholic extract of leaves of Ipomoea staphylina. Analgesic activity was evaluated by abdominal writhing, formalin-induced paw licking method and Eddy's hot plate test in mice. The hyd...

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Molecular Binding Modes Of Diarylheptanoids From Curcuma Comosa On The Er-Ss Receptor, Nathjanan Jongkon, Prasan Tangyuenyongwatana Jan 2014

Molecular Binding Modes Of Diarylheptanoids From Curcuma Comosa On The Er-Ss Receptor, Nathjanan Jongkon, Prasan Tangyuenyongwatana

The Thai Journal of Pharmaceutical Sciences

Curcuma comosa Roxb. is a medicinal plant that belongs to the Zingiberaceae family. The plant has been used in traditional Thai medicine for the treatment of postpartum uterine bleeding. The major compounds found in this plant are diarylheptanoids, which...

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Development And Evaluation Of Transdermal Patches Of Aceclofenac, Animesh Gairola, Urmi Chaurasia, Anupama Singh, Vikas Anand Saharan Jan 2014

Development And Evaluation Of Transdermal Patches Of Aceclofenac, Animesh Gairola, Urmi Chaurasia, Anupama Singh, Vikas Anand Saharan

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to develop and evaluate matrix-type transdermal therapeutic system containing aceclofenac with different ratios of hydrophilic polymers (hydroxylpropyl methylcellulose, sodium carboxy methylcellulose) and a hydrophobic polymer (...

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Synthesis And Biological Screening Of Some Thienyl And Phenyl Pyrazoline Derivatives As Antimalarial Agent, Abdu Tuha, Adnan A. Bekhit, Yimer Seid Jan 2014

Synthesis And Biological Screening Of Some Thienyl And Phenyl Pyrazoline Derivatives As Antimalarial Agent, Abdu Tuha, Adnan A. Bekhit, Yimer Seid

The Thai Journal of Pharmaceutical Sciences

Malaria is a common parasitic disease of the developing world and drug resistance has hindered their efficient control. Pyrazole derivatives were synthesized using aldol condensation and subsequent cyclization reactions. The compounds were synthesized in...

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In Silico Prediction Of Interaction Between Flavonoids Of Propolis Of Honey Bee And Anthrax Protective Antigen, Shahin Gavanji, Mohsen Doostmohammadi, Behrouz Larki Jan 2014

In Silico Prediction Of Interaction Between Flavonoids Of Propolis Of Honey Bee And Anthrax Protective Antigen, Shahin Gavanji, Mohsen Doostmohammadi, Behrouz Larki

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to check the interaction between four ligands (Acacetin, Chrysin, Naringenin and Caffeic Acid Phenethyl Ester) and protective antigen. These ligands are the main flavonoids of propolis of honey. Bioinformatics checking was done ...

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Dj-1 And Atp13a2: Two Proteins Involved In Parkinson’S Disease, Josephat M Asiago Jan 2014

Dj-1 And Atp13a2: Two Proteins Involved In Parkinson’S Disease, Josephat M Asiago

Open Access Dissertations

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 0.3% of the total U.S. population, and its prevalence increases with age. Two neuropathological hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta, a region in the midbrain involved in initiating and sustaining movement, and the presence of cytosolic inclusions called Lewy bodies (LBs) in various brain regions. LBs are enriched with fibrillar forms of the presynaptic protein &agr;-synuclein (aSyn). Two autosomal recessive genes implicated in familial PD are PARK9, encoding the P-type ATPase ATP13A2, a lysosomal ATPase; and …

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Characterizing A Novel Monoclonal Ampa Receptor 1/2/3 Antibody In The Hippocampus And Prefrontal Cortex Of Rat, Monkey, And Human, Sebastian Aguiar Jan 2014

Characterizing A Novel Monoclonal Ampa Receptor 1/2/3 Antibody In The Hippocampus And Prefrontal Cortex Of Rat, Monkey, And Human, Sebastian Aguiar

Pitzer Senior Theses

The excitatory, ionotropic glutamatergic AMPA receptor is the most common membrane-bound receptor in the central nervous system. AMPARs and the NMDA receptors are central to synaptic plasticity, memory, and mechanisms of neurodegeneration. The AMPAR is an obligate heterotetramer, composed of subunits GluA1-4. Subunit permutation determines ion conductance, trafficking and other functional characteristics. Few available antibodies are subunit-specific, disabling researchers from accurately visualizing differential AMPAR subunit distribution in the nervous system. This study sought to visualize a novel monoclonal GluA1/2/3 antibody with functional avidity for three of four receptor subunits and to characterize the ultrastructural localization of these receptors using confocal …

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Mechanisms Of Cyclooxygenase-2-Dependent Human Aortic Smooth Muscle Cell Phenotypic Modulation, Oreoluwa O. Adedoyin Jan 2014

Mechanisms Of Cyclooxygenase-2-Dependent Human Aortic Smooth Muscle Cell Phenotypic Modulation, Oreoluwa O. Adedoyin

Theses and Dissertations--Pharmacy

Abdominal aortic aneurysm (AAA) is a disease of the aorta characterized by pathological remodeling and progressive weakening of the vessel resulting in the increased risk of rupture and sudden death. In a mouse model of the disease induced by chronic Angiotensin II (AngII) infusion, progression of AAAs is associated with reduced differentiation of smooth muscle cells (SMCs) at the site of lesion development. In the mouse model, the effectiveness of cyclooxygenase-2 (COX-2) inhibition for attenuating AAA progression is associated with maintenance of a differentiated SMC phenotype. However, the safety of COX-2 inhibitors is currently in question due to the increased …

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Flavonoids With Novel Nicotinic Activity As Potential Pharmacotherapies To Treat Ethanol-Induced Neurotoxicity, Joseph A. Lutz Jan 2014

Flavonoids With Novel Nicotinic Activity As Potential Pharmacotherapies To Treat Ethanol-Induced Neurotoxicity, Joseph A. Lutz

Theses and Dissertations--Pharmacy

Ethanol causes neurotoxicity via several mechanisms at different points in the cycle of dependence, including neuroinflammation and oxidative stress during ethanol exposure as well as excitotoxicity during ethanol withdrawal. The primary therapeutic implication is that ethanol-induced neurotoxicity requires multifunctional pharmacotherapies which reduce all mechanisms. Using an innovative pharmacological high throughput screening method on a large plant extract library we discovered flavonoids with alpha7 nicotinic acetylcholine receptor (nAChR) activity. In addition to their well-known anti-inflammatory and antioxidant properties, this novel activity means they can potentially reduce excitotoxicity and therefore makes them ideal for inhibition of ethanol-induced neurotoxicity. Rhamnetin, the candidate compound, …

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Comparison Of Eight Published Models For Estimating Vancomycin Clearance From Creatinine Clearance In Thai Adult Patients, Aim-On Pradoo, Thitima Wattanavijitkul, Darunee Chotiprasitsakul, Duangchit Panomvana Jan 2014

Comparison Of Eight Published Models For Estimating Vancomycin Clearance From Creatinine Clearance In Thai Adult Patients, Aim-On Pradoo, Thitima Wattanavijitkul, Darunee Chotiprasitsakul, Duangchit Panomvana

The Thai Journal of Pharmaceutical Sciences

This prospective study was performed to determine the best published model for estimating vancomycin clearance from creatinine clearance (CLcr) in Thai adult patients with CLcr greater than or equal to 30 ml/min. Data from 36 adult patients, who were giv...

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Molecular Mechanisms Of Chemotherapeutic Resistance In Lung Cancer, Piyaparisorn Wongvaranon, Varisa Pongrakhananon, Pithi Chanvorachote Jan 2014

Molecular Mechanisms Of Chemotherapeutic Resistance In Lung Cancer, Piyaparisorn Wongvaranon, Varisa Pongrakhananon, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Lung cancer mortality is mainly due to the high rate of chemotherapeutic resistance frequently found in lung cancer patients. In order to develop the novel strategies for effective treatment, the molecular basis regarding adaptive machineries of lung can...

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Understanding The Medication Experiences Of Thai Patients Attending A Medication Therapy Management Clinic, Phantipa Sakthong, Win Winit-Watjana, Rungpetch Sakulbumrungsil Jan 2014

Understanding The Medication Experiences Of Thai Patients Attending A Medication Therapy Management Clinic, Phantipa Sakthong, Win Winit-Watjana, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

The study aimed to explore Thai patients' medication experiences in five domains, i.e., attitudes, understanding, expectations and wants, concerns, and convenience of medicine use. This cross-sectional descriptive study was carried out using a qualitativ...

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Identification And Antimicrobial Activity Of Streptomyces Strains From Thai Mangrove Sediment, Wongsakorn Phongsopitanun, Khanit Suwanborirux, Somboon Tanasupawat Jan 2014

Identification And Antimicrobial Activity Of Streptomyces Strains From Thai Mangrove Sediment, Wongsakorn Phongsopitanun, Khanit Suwanborirux, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Two actinomycete strains, D2-1 and D2-2, were isolated from mangrove sediment sample collected from Samut Song Kram province, Thailand. On the screening of antimicrobial activity, the crude extracts of fermentation broth of both strains exhibited activit...

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Gigantol-Induced Apoptosis In Lung Cancer Cell Through Mitochondrial-Dependent Pathway, Sopanya Charoenrungruang, Pithi Chanvorachote, Boonchoo Sritularak, Varisa Pongrakhananon Jan 2014

Gigantol-Induced Apoptosis In Lung Cancer Cell Through Mitochondrial-Dependent Pathway, Sopanya Charoenrungruang, Pithi Chanvorachote, Boonchoo Sritularak, Varisa Pongrakhananon

The Thai Journal of Pharmaceutical Sciences

Lung cancer is identified as a major cause of cancer-related death. Death in this cancer associates with the acquisition of apoptosis avoidance mechanism. Apoptosis, a programmed cell death mechanism, plays an important role on normal cell development an...

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Balancing Accountability For Adverse Drug Reactions Under American Product Liability Law: Lessons For Thailand?, Sakda Thanitcul, Matthew Lim Braslow Jan 2014

Balancing Accountability For Adverse Drug Reactions Under American Product Liability Law: Lessons For Thailand?, Sakda Thanitcul, Matthew Lim Braslow

The Thai Journal of Pharmaceutical Sciences

Drugs that are powerful enough to cure disease are powerful enough to do potential harm. This common saying among physicians is the central point of this paper. When harm to a patient does occur, the sense of society requires that where and when appropri...

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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function, Enbo Zhan Jan 2014

Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function, Enbo Zhan

Wayne State University Dissertations

Adenosine A2B receptor (A2BR) appear to contribute to chronic inflammation. This receptor is highly expressed in macrophages and cardiac fibroblasts, cells which play key roles in inflammation and healing following myocardial infarction (MI). A2BR have been shown to induce collagen production and promote organ fibrosis, although the reports of A2BR role on MI are limited and conflicting. The results of cardiac fibroblast (CF) studies however suggest that non-selective A2BR stimulation inhibits collagen expression. The hypothesis of the present study was that deletion of A2BR reduces adverse remodeling in post-MI, …

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Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn Jan 2014

Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Hemin (iron (III)-protoporphyrin IX) is found that it is elevated in the plasma of thalassemic patients and is a possible cause of oxidative stress-promoting atherosclerosis. Deferiprone (L1), an iron chelator, can prevent free radical formation catalyze...

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Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers Jan 2014

Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers

The Thai Journal of Pharmaceutical Sciences

Modifications on C8 position of purine base have been studied for their effects on B-DNA to Z-DNA conversion. The 8-bromo and 8-carboxyphenyl adduct are among the most potent Z-DNA facil tators and hence arc aimed to be utilized for Z-DNA based probe lor...

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