Pharmacology, Toxicology and Environmental Health Commons^™

Effects Of Chamomile And L-Theanine Beverage On Menstrual Pain, Menstrual Symptoms, Mood, And Sleep Quality In Young Women Experiencing Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled Study, Ziqing Soh, Soo Cing Tan, Tak Hiong Wong, Seok Tyug Tan, Seok Shin Tan, Chin Xuan Tan

Journal of Food and Drug Analysis

Primary dysmenorrhea is one of the most common complaints among young women. This study aimed to evaluate the effects of chamomile and L-theanine beverage intake on menstrual symptoms, pain intensity, mood, and sleep quality in young adult females with primary dysmenorrhea, using a two-phase continuous study design. In the first phase, a cross-sectional study was conducted to assess the prevalence of primary dysmenorrhea. In the second phase, participants were randomly assigned to either the intervention group (n =15), which consumed chamomile and L- theanine beverage (CTT), or the control group (n =15), which consumed chamomile-flavored beverage (non-CTT). Beverages …

Cordycepin In Cancer Therapy: A Bibliometric Analysis And Review Of Mechanisms, Zhiwei Ouyang, Yufei Zhang, Jianghan Ning, Yayi Tu, Bin He

Journal of Food and Drug Analysis

Cordycepin (3’-deoxyadenosine), a major bioactive component derived from fungi of the genus Cordyceps, has garnered significant attention in recent years for its potent antitumor properties. Drawing on literature indexed in the Web of Science Core Collection from 2004 to 2025, this study employs bibliometric tools―specifically CiteSpace and VOSviewer―to systematically examine developmental trends, research hotspots, and emerging frontiers in the field of cordycepin-related cancer research. The analysis maps a shift in focus from early-stage pharmacological validation to more advanced investigations into molecular mechanisms, with particular emphasis on cell cycle regulation. Keyword burst analysis highlights bursts in terms such as “apoptosis,” “cell …

Distinguishing Avocado Oil Quality Based On Fatty Acid Profile Using Pca: A Review Of Influencing Factors And Research Gaps, David Fernando, Ali Ridho Arif Madja, Nur Azizah, Agustina Ari Murti Budi Hastuti, Abdul Rohman

Journal of Food and Drug Analysis

The quality of avocado oil is influenced by multiple factors, including cultivar, growing region, drying method, harvest season, fruit maturity, extraction technique, and storage conditions. This review aims to show how fatty acid profiles (FAP), combined with principal component analysis (PCA), can be used to characterize avocado oil based on various established factors. A total of 23 peer-reviewed articles were included, encompassing 143 data points. PCA was applied as an exploratory tool to reduce dimensionality and visualize patterns in the data. Among the evaluated variables, the fruit part emerged as the most influential determinant, allowing clear categorization of avocado oils …

The Cytotoxicity And Anti-Inflammatory Properties Of 1’S-1’-Acetoxychavicol Acetate (Aca) On Oral Cells, Nur Umairah Atiqah Sabri, Nor Syazwani Muhammad Zahidan, Zulfahmi Said, Siti Noor Adnalizawati Adnan, Normaliza Ab Malik

Journal of Dentistry Indonesia

Objective: Mouthwash is widely used to maintain oral health by reducing the prevalence of pathogenic microbiomes. Nonetheless, chlorhexidine, a common active ingredient, is associated with side effects including teeth staining, mucosal peeling, mouth and tongue numbness. This has prompted interest in natural alternatives. This study aimed to identify the cytotoxicity and anti-inflammatory properties of 1’S-1’-acetoxychavicol acetate (ACA) isolated from Alpinia conchigera rhizome against human primary gingival fibroblast and keratinocyte (HPGF and HPGK). Methods: Cytotoxicity of ACA (1.57 mg/mL) against HPGF and HPGK was assessed using the MTT assay. Meanwhile, the anti-inflammatory property of ACA was analyzed based on …

The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota, And Metabolic Syndrome, Emily Bayliss

Senior Honors Theses

Type 2 diabetes mellitus (T2DM) is a growing global health concern characterized by peripheral insulin resistance as well as impaired insulin secretion from pancreatic β-cells. Emerging evidence suggests that the gut microbiome, specifically gut dysbiosis, an imbalance in the gut microbiome, is a critical modulator of the pathophysiology of T2DM. Dietary polyphenols, a diverse group of bioactive compounds that are abundant in plant-based foods, have recently gained attention for their potential to attenuate metabolic disorders through their antioxidant and anti-inflammatory properties as well as through modulating the composition and activity of gut microbes, thereby attenuating dysbiosis. However, the diabetic state …

Development Of A Method For Using Effective Elements For The Storage Of Electrical Energy, Jasur M. Melibaev, Nasiba U. Abduraimova, Sardor S. Abriev, Yulbarskhon N. Mansurov

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the work is to find ways to use cryotic metals that also provide added value to the economy, using the example of tantalum and zirconium. Among the critical metals, there are those that are rarely found in the Earth’s crust but possess unique properties. These include tantalum and zirconium. While zirconium finds industrial applications, tantalum is still rarely used – its main application in capacitors for producing phones, computers, and automotive electronics. A small amount of tantalum is used to make hard alloy elements. Analysis showed that between zirconium and tantalum, there is a mixture of two …

Marigold-Silver Nanoparticles (Agnps) Complex: Characterization, Therapeutic Potential, And Future Approaches For Lung Injury Via Antioxidant And Anti-Inflammatory Effects, Navdeep Kaur

USF Tampa Graduate Theses and Dissertations

Chronic respiratory diseases (CRDs) and other lung conditions are a key cause of the problems facing global health, as they greatly increase morbidity, death, and the financial burden. In order to achieve the third Sustainable Development Goal of the United Nations, which is to reduce premature mortality from non-communicable illnesses by one-third by 2030, updated epidemiological statistics are crucial for directing prevention, control, and treatment measures. One of the major reasons of illness and death globally is chronic obstructive pulmonary disease (COPD). Lung damage and the emergence of CRDs, such as asthma, emphysema, COPD, and other respiratory disorders, are largely …

Formulation And Characterization Of Albumin Nanoparticles For Nsclc Photochemotherapy, Faisal Mohammad Shamim Khan

USF Tampa Graduate Theses and Dissertations

Non-small Cell Lung Cancer (NSCLC) is the most common type of lung cancer and is a leading cause of worldwide cancer-related death, which is a strong motivation to develop more efficacious approaches to its treatment. This thesis outlines the construction of folate-targeted bovine serum albumin (FA-BSA) nanoparticles co-loading Chlorin e6 (Ce6), a photodynamic therapy photosensitizer, and Evofosfamide (EVO), a hypoxia-activated prodrug, to enable synergistic photochemotherapy. The 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is a water-soluble carbodiimide coupling reagent and used for amide bonds between carboxylic acid and amines. FA-BSA nanoparticles were prepared through a desolvation approach and stabilized through crosslinking by the carbodiimide reagent …

Development And Validation Of An Analytical Method For Determination Of Bongkrekic Acid In Biofluids For Toxin Monitoring, Ying-Tzu Shieh, Te-I Weng, Ju-Yu Chen, I-Ting Wang, Kevin Shu-Leung Lai, Chia-Mo Lin, Chu-Yun Teng, Guan-Yuan Chen

Journal of Food and Drug Analysis

Bongkrekic acid (BKA) poisoning is a severe foodborne illness with a high mortality rate. This study aimed to identifyBKA in postmortem tissues from poisoning victims in Taiwan and to develop a reliable analytical method for detectingBKA in biofluids to aid clinical diagnosis and treatment. BKA was identified in postmortem samples using high-reso-lution mass spectrometry (HRMS) and confirmed with an independent ultrahigh-performance liquid chromatographycoupled with tandem mass spectrometry (UHPLC-MS/MS) method. To meet clinical needs, a UHPLC-MS/MS methodwas developed and validated for BKA detection in plasma and urine. Method optimization included adjustments to ionsource conditions for multiple reaction monitoring (MRM) transitions and …

The Economic Burden Of Covid-19 In A Region With Stringent Response Measures: A Case Study Of Taiwan, Elise Chia-Hui Tan, Fei-Yuan Hsiao, Ming-Chin Yang

Journal of Food and Drug Analysis

The COVID-19 pandemic has imposed a significant economic burden globally, particularly in regions with stringentresponse measures. This study aimed to assess the economic impact of COVID-19 in Taiwan, focusing on both directand indirect costs. A cost-of-illness analysis was conducted, utilizing data from the Taiwan Centers for Disease Control(CDC), national databases, epidemiological studies, and economic surveys. The analysis included both direct costs (e.g.,hospital admissions, outpatient care) and indirect costs (e.g., productivity losses due to long COVID, absenteeism, caregiving duties). The study encompassed Taiwan's population of 23.2 million, with particular attention to age-specific impacts on economic outcomes. The total economic burden of …

Nanovesicles Derived From Protocorm-Like Bodies Of Dendrobium Officinal Enhance Corneal Epithelial Repair And Reduce Inflammation In Dry Eye Disease Models, Bao Yuqing, Peng Chengyu, Zhang Fenglei, Zheng Yuqiang, Zhang Mingqi, He Wei

Journal of Food and Drug Analysis

Plant-derived nanovesicles (PDNVs) offer a promising, biocompatible therapeutic platform. In this study, we isolatednanovesicles from protocorm-like bodies of Dendrobium officinale (PLBs-NVs) and evaluated their efficacy in dry eyedisease (DED) models. PLBs-NVs protected human corneal epithelial cells against hyperosmotic stress, supportedwound repair, and inhibited inflammation in vitro. In a desiccating stress-induced DED mouse model, topical PLBs-NVstreatment significantly restored tear secretion, reduced corneal epithelial damage, and lowered levels of proinflammatorycytokines. These results suggest that PLBs-NVs are a safe, natural, and effective therapeutic strategy for DED, sup-porting their potential for future clinical translation in ocular surface disorders.

Anti-Neuroinflammatory Polyketides From The Medicinal Herb-Derived Fungal Strain Didymocyrtis Brachylaenae Km1530, Chia-Hao Chang, Yun-Rong Zhang, Shu-Jung Huang, George Hsiao, Wei-Chiung Chi, Andrea Gu, Yu-Wei Lai, Tzong-Huei Lee

Journal of Food and Drug Analysis

A series of chromatographic separation on the liquid-state fermented products of Didymocyrtis brachylaenae Km1530 derived from the littoral medicinal herb Atriplex maximowicziana Makino, resulted in the isolation of compounds 1—13. Their structures were determined by spectroscopic analysis as fivepreviously unreported C13 polyketides, namely brachylactones A—D (1—4) and brachic acid (5), along with eight known compounds 6—13. Among these, brachy-lactones A (1) and B (2) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-induced murine BV- 2 microglial cells at a concentration of 20 μM without any cytotoxicity.

Protective Effects Of Jujube Seed Extract Against Oxidative Stress In Ht22 Cells And Its Sleep-Promoting Action Through Gabaergic Receptors, Seok Hyun Chung, Hyeongyeong Kim, Singeun Kim, Pan-Young Jeong, Hyowon Lee

Journal of Food and Drug Analysis

Jujube seed extract (JSE), rich in polyphenols and flavonoids, exhibits neuroprotective and sleep-enhancing properties.In vitro, JSE protected HT22 cells against oxidative stress by activating the Nrf2/HO-1 pathway and upregulatingantioxidant enzymes. In vivo, JSE increased non-REM sleep and delta wave activity in pentobarbital- and caffeine-induced sleep models. Spinosin contributed to these effects. Long-term JSE administration upregulated GABAA, GABAB, and 5-HT1A receptors in brain tissue. These findings suggest that JSE offers dual benefits in mitigating oxidativestress and promoting sleep through antioxidant defense and neurotransmitter modulation, supporting its potential as a natural therapeutic agent.

Repurposing Dihydroartemisinin As A Novel Anticancer Agent Against Colorectal Cancer Stem Cells, Meng-Han Wu, Chieh-Ju Sung, Fan-Lu Kung, Jih-Hwa Guh, Yu Su, Lih-Ching Hsu

Journal of Food and Drug Analysis

Colorectal cancer (CRC) is one of the leading causes of cancer-related death globally and discovering novel therapeuticagents to treat the disease, and prevent cancer metastasis and recurrence is an urgent medical need. Cancer stem cells(CSCs) capable of self-renewal and differentiation are generally considered the cause of tumor metastasis, recurrenceand chemoresistance. Hence, targeting CSCs may be a promising strategy for the treatment of cancer. GATA6, a zincfinger transcription factor, contributes to tumorigenesis in CRC and is related to cancer stemness. GATA6-overexpressing stable clones OE4 and OE6 derived from HCT116 cells were previously established and exhibitedincreased stemness properties. In this study, we …

Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models, Si-Si Han, Li-Yun Song, Peng-Tao Liang, Yin-Ying Wang, Yi Ying, Li Li, Jia-Li Yuan, Zhong-Shan Yang

Journal of Food and Drug Analysis

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by various pathologicallesions and an imbalance in the microflora. The Yi-Qi-Xuan-Fei Formula (YQXF) is a clinically effective formula withpharmacological potential to delay the progression of COPD. This study aims to explore the relationship between thetherapeutic mechanism of YQXF and the microflora in COPD. Our study found that YQXF reduces inflammatory injuryand inflammatory cell infiltration in lung tissue, repairs the intestinal mucosal barrier, and enhances immune function.Additionally, YQXF regulates the pulmonary and intestinal flora by increasing the abundance of Alloprevotella, Rose-buria, Oscillibacter, and Lactobacillus, while reducing the abundance of …

Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma

Journal of Food and Drug Analysis

Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …

The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh

Journal of Food and Drug Analysis

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology involving genetic,environmental, and metabolic factors. Among these, circadian rhythm disruption has emerged as a crucial but under-explored contributor to disease progression. The circadian system, regulated by the suprachiasmatic nucleus (SCN),controls essential physiological functions such as the sleep-wake cycle, metabolism, and neuroendocrine signaling.Disruption of this system has been increasingly linked to key pathological features of AD, including amyloid-betaaccumulation, tau hyperphosphorylation, and neuroinflammation. This review critically examines the mechanistic roleof circadian misalignment in AD by analyzing studies on sleep disturbances, SCN degeneration, metabolic dysregu-lation, clock gene polymorphisms (BMAL1, CLOCK, PER, …

Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar

Journal of Food and Drug Analysis

Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …

In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar

Journal of Food and Drug Analysis

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss,oxidative stress, neuroinflammation, and a-synuclein aggregation. Despite advances, current treatments only offersymptomatic relief without altering disease progression. This review aims to evaluate the therapeutic potential of plant-derived phytochemicals in PD through evidence from both in vivo and in vitro experimental models. Key findingsindicate that rodent models (e.g., MPTP, rotenone) and neuronal cell lines (e.g., SH-SY5Y) help replicate PD pathologyand mechanistic insights. Phytochemicals such as baicalein, morin, ferulic acid, and bacopa demonstrate neuroprotectiveeffects via antioxidant, anti-inflammatory, and mitochondrial-stabilizing pathways. Nanotechnology and brain orga-noids further improve translational relevance. In conclusion, …

Global Research Trends On Avocado Oil And Its Fatty Acid Composition: A Bibliometric Review, Ahmad Kamrullah Aras, Abdul Rohman

Journal of Food and Drug Analysis

The high content of unsaturated fatty acids in avocado oil (Persea americana) has prompted in-depth exploration across research subjects. This study uses bibliometric analysis to assess global research trends on avocado oil and its fatty acid composition from 2004 to 2024. The search string retrieved 255 articles from the Scopus database and then analyzed using R BibliometriX and VOSviewer software. These tools analyze descriptive structures and collaborative patterns and create network data maps. For comparison, we separated the data into two research periods, namely 2004-2013 and 2014-2024. There was a significant increase in the number of publications, with …

Enhancing Cataract Surgery Outcomes: Optimal Use Of Pre- And Post-Operative Eye Drops, Keith Skolnick M.D., Anu Valiaveedu

Mako: NSU Undergraduate Student Journal

Many preoperative and postoperative cataract patients struggle with comprehending the use of prescription medication as directed. Language barriers and low health literacy levels are major factors contributing to improper use of prescriptions. To increase patients comprehension, the Fort Lauderdale Eye Institute employed an educational intervention consisting of a live presentation and an instructional video. Results found that 44% of patients were hesitant to ask questions to clinical staff, 32% felt overwhelmed, and nearly 70% lacked confidence in using their prescribed eye drops. Following the intervention, 91% of patients reported increased confidence in their medications, and most indicated that the video …

Comparative Expression Of Cgmp-Dependent Protein Kinase G (Pkg) From Plasmodium And Toxoplasma, Tsopmo Asaah

Theses, Dissertations and Culminating Projects

Malaria and Toxoplasmosis are life threatening diseases to humans. The search for a cure and control of these diseases is still one of the major challenges of scientists worldwide. In this research we focused on two Malaria species; Plasmodium bergei² (Pb) and Plasmodium falciparum¹ (Pf) and also on Toxoplasma gondii. Part of the life cycle of these organisms is regulated by the enzyme cyclic GMP-dependent protein kinase G (PKG)⁴. This is our drug target in this research. We believe that inhibiting this enzyme will be a great step in fighting these diseases. In this research, we devised a comparative study …

Utilization Of Bixin-Loaded Polycaprolactone Nanoparticles To Ameliorate E-Cigarette-Induced Damage To Human Bronchial Epithelial Cells, Sophia R. Claymore

USF Tampa Graduate Theses and Dissertations

Electronic cigarettes (e-cigs) have increased in popularity and usage over the last few decades. E-cigs are generally composed of a liquid containing nicotine flavoring chemicals, a battery, a vaporization chamber, and a coil that heats the liquid upon inhalation of the mouthpiece. E-cigs were initially introduced as a healthy alternative to cigarette smoking. However, recent research has demonstrated that e-cigs elicit comparable cytotoxic and dangerous effects to conventional cigarettes. Bixin has been introduced in recent research as a candidate for therapeutic applications due to its innate anticancer, antioxidative, and anti-inflammatory characteristics. Nanoparticles (NPs) have emerged over the past few decades …

Yiqi Yangyin Tongluo Prescription Targets Lncrna Vim-As1 To Regulate Foxk2/Mtor To Promote Autophagy And Inhibit Renal Tubular Epithelial Cell Apoptosis, Rucui Yu, Ruiying Wu, Tingting Chen, Jingwei Xu

Journal of Food and Drug Analysis

Diabetic nephropathy (DN) is one dominating reason for death in diabetic patients, and its incidence is high. It has been reported that Yiqi Yangyin Tongluo prescription (YYTP) can relieve inflammation, and it owns better clinical effects in the treatment of DN. However, the molecular mechanisms of YYTP in the treatment of DN still keep unclear, and deeply investigations are needed. In this study, it firstly was manifested that YYTP can repress the lncRNA VIM-antisense 1 (VIM-AS1) expression in high glucose (HG)-evoked HK-2 cells. Overexpression of VIM-AS1 roll-backed the inhibitive impacts of YYTP on cell apoptosis in HG-triggered HK-2 cells. Additionally, …

Evaluating The Cost-Effectiveness Of Atezolizumab-Bevacizumab In Advanced Hepatocellular Carcinoma: Insights From Taiwan, Tsung-Wei Chang, Wei-Chiao Chang, Wan-Hsuan Chou, Wei-Pin Chang, Chun-Nan Kuo

Journal of Food and Drug Analysis

Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectable hepatocellular carcinoma. Despite its clinical benefits, the high cost associated with this treatment poses a substantial challenge in routine practice in Taiwan. This study aims to assess the cost-effectiveness of atezolizumab plus bevacizumab in comparison to sorafenib monotherapy. This study utilized partitioned survival analysis and extrapolated survival over a 20-year horizon to conduct a cost-effectiveness analysis from the perspective of the National Health Insurance Administration. Efficacy and utility data …

Ping-Chong-Jiang-Ni Formula Effectively Inhibits Migration And Invasion Of Endometriosis 12z Cell Line Via Trip13, Jiahua Peng, Shuzhen Liu, Yunxiang Xie, Min Xiao, Chichiu Wang, Ruining Liang

Journal of Food and Drug Analysis

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that PCJNF inhibits the proliferation and induces the apoptosis of ectopic endometrial stromal cells (EESCs) by modulating the JNK signaling pathway. In our most recent study, published in January 2024, we found that PCJNF effectively alleviates EMs-associated pain by reducing inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF). Furthermore, PCJNF down-

regulates the expression of transient receptor potential vanilloid 1 (TRPV1), phosphorylated TRPV1 (p-TRPV1), and protein …

In Vitro Metabolic Profiling Of Methylenedioxy-Substituted Synthetic Cathinones For Enhanced Detection In Urine Sample Analysis, Ya-Ling Yeh, Chin-Lin Hsieh, Yi-Jia Huang, Yu-Hsiang Chang, Sheng-Meng Wang

Journal of Food and Drug Analysis

Synthetic cathinones are a widely abused class of new psychoactive substances that pose significant challenges in forensic toxicology owing to their complex metabolic pathways and lack of verified reference standards. This study investigated the in vitro metabolism of nine methylenedioxy-substituted synthetic cathinones, including methylone and eight structural isomers, which were categorized into three groups: Group 1 (dimethylone, ethylone, and butylone), Group 2 (dibutylone, pentylone, and eutylone), and Group 3 (N-ethylpentylone and dipentylone). Pooled human liver microsomes, cytosol, and uridine diphosphate glucuronic acid were used to identify phase Ⅰ and Ⅱ metabolites by liquid chromatography–quadrupole time-of-flight mass spectrometry. Key pathways included …

Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu

Journal of Food and Drug Analysis

Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …

Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response, Huimin Pei, Mengyuan Zhao, Hongyue Wang, Xindi Zhang, Caihong Shi, Xiangrong Zhang

Journal of Food and Drug Analysis

Jiao Sanxian (JSX) consists of three traditional Chinese medicine including charred hawthorn, malt and Liu Shen Qu, they are also from Chinese medicine homologous food. It is commonly used to relieve functional dyspepsia (FD). The present study aims to explore the mechanism of JSX (granule), with the addition of prebiotics for the treatment of FD using mice model. The network pharmacology and molecular docking were used to forecast therapeutic targets for JSX. Based on the protein-protein interaction (PPI) results, thirteen targets exhibited strong interactions with each other. The results of network pharmacology and molecular docking revealed therapeutic activity of JSX …

Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan, Shirley Pan, Jia-Chuan Hsu, Kuo-Teng Hung, Ching-Jung Ho

Journal of Food and Drug Analysis

Products containing live microorganisms may be classified as food or drugs depending on their intended use; live biotherapeutic products (LBPs) with therapeutic claims are defined as medicinal products containing live bacteria or yeasts intended to prevent or treat disease. Based on their characteristics, LBPs are classified as biological drugs and must be registered as biological drugs before they can enter the Taiwanese market. As research into the microbiota and its role in health and disease continues to advance, LBPs are expected to play an increasingly important role in medicine and biotechnology. With the growing popularity of microbial applications in recent …