Human and Clinical Nutrition Commons^™

Therapeutic Potential Of A Ketogenic Diet In The Treatment Of Major Depressive Disorder, Jordan A. Murrin

Masters Theses, 2020-current

Major depressive disorder (MDD) is the second most common mental health condition and a leading cause of disability in the world. It is theorized that MDD develops from a combination of biological, psychological, and social stressors. The condition is typically treated using pharmaceuticals and psychotherapy. However, not all individuals with MDD have access to or choose to use these treatments, or may prefer to incorporate therapeutic lifestyle changes such as exercise, sleep, and healthy eating. Even with treatment, MDD can alter brain structure and function, leading to the development of comorbid mental health and chronic metabolic conditions like obesity, cardiovascular …

Incorporating Physical Activity Into Your Daily Life, Erin Howie

Diet, Food, Exercise, and Nutrition (D-FEND)

Different forms of physical activity, ways to incorporate physical activity into your daily life, things to consider when choosing a fitness monitor & how to workout safely during COVID-19 pandemic.

Elucidating The Relation Between Human Milk Fatty Acids, Extracellular Vesicles, And Infant Developmental Outcomes In The First Year Of Life, Diana Bickmore

Food Science (MS) Theses

For most infants, human milk is the recommended source of nutrition. Improved developmental outcomes have been reported in infants that consume human milk compared to infant formula. Essential fatty acids (EFAs) confer health benefits. However, EFAs cannot be synthesized by the body, and therefore must be consumed in diet. Extracellular vesicles (EVs) are nanoparticles containing a lipid bilayer membrane and are present in human milk. Methods of EV isolation such as ultracentrifugation (UC) may not be feasible for the study of EVs in human milk due to the need for large sample volume, which may not be available. The objectives …

Introduction To Exercise Is Medicine, Erin Howie

Diet, Food, Exercise, and Nutrition (D-FEND)

An introduction to how exercise is medicine and can promote health-related benefits.

Fasting Diets: Are They Safe, Healthy, And Effective?, Carrie Durward, Keshele Stevens

All Current Publications

Diets are commonly prescribed to induce weight loss and reduce the risk of many diseases. Because a standard daily calorie restriction diet is often hard to maintain, other diet alternatives such as fasting diets were created. Fasting diets have been found to be effective, though they may not be any more effective than typical diets. Before beginning a fasting diet, it is best to seek professional medical advice to assess individual risks and circumstances. This fact sheet helps readers learn more about the safety, health, and effectiveness of fasting diets.

Added Sugars: What You Need To Know, Carrie Durward, Keshele Stevens

All Current Publications

Added sugar has become a hot topic among health professionals and in the media. Based on the best available evidence, health professionals recommend that less than 10% of daily calories come from added sugar (U.S. Department of Health and Human Services [HHS] & U.S. Department of Agriculture [USDA], 2015c) in order to maintain a balanced diet with all the important nutrients. In this fact sheet, we will address why and how to limit added sugar in your diet, what it is, and where to find it.

Healthy Eating Patterns, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Focusing on what is an eating pattern and how to understand and incorporate a healthy eating pattern into everyday life.

Basics Of Nutrition, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Introduces the basics of nutrition.

Introduction To Diet, Food, Exercise, And Nutrition (D-Fend) 2.0, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

An Introduction to project DFEND 2.0!

Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane

Graduate Theses and Dissertations

Diets, through multiple mechanisms, cause significant impact on human health and disease etiology; proposed modes of action include modulation of non-coding RNAs and influences on the gut microbiome. Specifically, phytochemicals change human miRNA expression thereby impacting gut microbiome and/or increasing host immune functions. Apiaceous and cruciferous vegetables have been linked to decreased chronic inflammation, which is closely related with the host immune system, yet it is not investigated how these two classes of vegetables influence the colonic miRNA profile. In this study, therefore we aimed to determine the effects of short-term feeding of broccoli and carrot to infants on fecal …

Microrna-Mrna Co-Sequencing Identifies Transcriptional And Post-Transcriptional Regulatory Networks Underlying Muscle Wasting In Cancer Cachexia, Geysson Javier Fernandez, Juarez Henrique Ferreira, Ivan Jose Vechetti Jr, Leonardo Nazario De Moraes, Sarah Santiloni Cury, Paula Paccielli Freire, Jayson Gutierrez, Renato Ferretti, Maeli Dal-Pai-Silva, Silvia Regina Rogatto, Robson Francisco Carvalho

Department of Nutrition and Health Sciences: Faculty Publications

Cancer cachexia is a metabolic syndrome with alterations in gene regulatory networks that consequently lead to skeletal muscle wasting. Integrating microRNAs mRNAs omics profiles offers an opportunity to understand transcriptional and post-transcriptional regulatory networks underlying muscle wasting. Here, we used RNA sequencing to simultaneously integrate and explore microRNAs and mRNAs expression profiles in the tibialis anterior (TA) muscles of the Lewis Lung Carcinoma (LLC) model of cancer cachexia. We found 1,008 mRNAs and 18 microRNAs differentially expressed in cachectic mice compared with controls. Although our transcriptomic analysis demonstrated a high heterogeneity in mRNA profiles of cachectic mice, we identified a …

The Influence Of Anti-Inflammatory Diets On The Reduction Of Symptoms Of Inflammatory Bowel Disease, Kelly Stanton

Honors Thesis

A person’s diet is a highly modifiable facet of lifestyle someone can change in order to alter their internal bodily processes. One of these processes is inflammation. While inflammation is beneficial as part of an acute immune response, it can become detrimental to a person’s health if it becomes chronic. There are many dietary factors that can be examined in order to avoid or diminish chronic, unwarranted, inflammation. This paper focuses on how people can change their dietary patterns to control symptoms of Inflammatory Bowel Disease (IBD), an immune-mediated inflammatory condition that is heavily influenced by excessive inflammation in the …

Optimization Of Dna Extraction From Human Milk, Cassandra Z. Rutherford

Graduate Theses

Background: Techniques are emerging for determining the best and most cost-effective way to test for human milk adulteration. Currently, the literature is focused on the use of qPCR testing, a technique used to isolate and amplify pieces of DNA for analysis. However, no recommendation currently exists on the best DNA extraction kit to use to achieve optimal DNA yield or purity from human milk samples for downstream qPCR use. Thus, the objective of this study is to assess and compare two DNA extraction kits for use with human milk samples for future DNA-based analysis in the testing for bovine milk …

Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background

Micronutrient inadequacy has been found at higher levels in overweight and obese individuals in a broad range of ages relative to healthy weight. Insufficient micronutrient levels can have a negative impact on physical and mental health along with excess weight.

Objective

Due to health consequences related to inadequate micronutrient intake and the understanding that the general population not only fails to meet the majority of micronutrient recommendations, but is also overweight or obese, the objective of this study is to first, determine if young adults in the Northwest Arkansas Region are consuming adequate levels of micronutrients and second, if …

Microbiome Diversity And Differential Abundances Associated With Bmi, Immune Markers, And Fecal Short Chain Fatty Acids Before And After Synbiotic Supplementation, John Sterrett, W Andrew Clark, Michelle Chandley

Undergraduate Honors Theses

The gut microbiota and its metabolites – namely short chain fatty acids (SCFAs) – interact with the digestive, immune, and nervous systems. Microbiota with disrupted composition are highly associated with obesity, gastrointestinal symptoms, and chronic inflammation. Levels of SCFAs in the feces can represent dynamics of the microbiota, and they represent one mechanism by which the microbiota interacts with its host. This study aimed to further our understanding of associations between microbiota bacterial diversity and SCFAs, immune markers, BMI, and GI symptoms and to identify bacteria that are differentially abundant in different BMI groups and with synbiotic supplementation. Data (SCFAs, …

The Effect Of Protein And Omega-3 Fatty Acid Supplementation On Regulation Of Sleep And Mood In Postmenopausal Women, Caroline Baughn

Biological Sciences Undergraduate Honors Theses

The older population of the United States is in a period of rapid growth [1]. population of those in the United States aged 65 or older will double to about 72 million in the next 25 year [1]. This population is at increased risk for obesity, chronic diseases, decreased quality of life, and premature death. Therefore, guidelines for healthy aging are desperately needed. In 2015 alone, 67.7% of adults in the United States aged 65 or older reported having two or more chronic conditions [2]. Treatment for those in the older population afflicted by multiple chronic conditions alone accounts for …

The Role Of Higher Protein Diets In The Regulation Of Mood And Sleep In Patients With Metabolic Syndrome, Mckenzie Fellinger

Biological Sciences Undergraduate Honors Theses

Metabolic Syndrome is becoming a more prevalent health issue within the United States, currently affecting 22% of adults (Capuron et al., 2008). Several factors contribute to the diagnosis of Metabolic Syndrome, including obesity, high levels of triglycerides, elevated blood pressure, and low high-density lipoprotein cholesterol. Metabolic Syndrome puts those who have it at an increased risk for numerous diseases, such as type 2 diabetes, cardiovascular disease, and cancer (Jennings et al., 2007). Several studies have shown that Metabolic Syndrome plays a negative role in sleep and mood of those with the disease. Individuals with Metabolic Syndrome often have poor sleep …

The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli

Graduate Theses and Dissertations

The prevalence of childhood overweight and obesity is an ongoing concern. Currently, approximately 20% of children in the United States are obese. While obesity was once regarded merely as excessive adiposity within the body, it is has emerged as a major risk factor for chronic diseases such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. Obesity is multifactorial in nature. Weight gain can result from an energy imbalance in the body due to excess energy intake (calories in) and decreased energy expenditure (calories out). Identifying methods to combat obesity is essential. Nutritional intervention may be a strategy to help …

Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft

Graduate Theses and Dissertations

Micronutrients are essential for both physical and mental health. There is a correlation between poor health and mood and micronutrient deficiencies. Young adults age 18-24 are an at-risk, understudied population likely to benefit from multivitamin mineral supplementation. Multivitamin mineral supplementation is a potential way to bridge gaps in micronutrient levels, thus influencing health-related outcomes. Here, we provide the first attempt at influencing health-related quality of life and physical activity with a multivitamin mineral supplement in young adults. Using a supplement formulated without herbal extracts and caffeine, this double-blind study examined the efficacy of a daily multivitamin mineral supplement for 30 …

Zika Virus Induces Apoptosis In Retinal Pigmented Epithelial Cells, Madison Kraus, Philma Glora Muthuraj, Sathish Kumar Natarajan

UCARE: Research Products

Zika virus is a single-stranded positive sense RNA virus that attracted international attention in 2015 when an epidemic broke out in Brazil. This vector borne virus is transmitted by mosquitos and is especially concerning for pregnant women because the virus can affect the development of the fetus. One known complication is the destruction of infected retinal epithelial cells. The transduction of light is interrupted due to cell death and results in blind spots. Previous research has demonstrated that palmitoleate can reduce the observed levels of apoptosis in ZIKAV infected JEG-3 cells. We have also seen the protection of retinal pigmented …

Breastfeeding Or Formula Feeding: A Mother's Choice, Trista Briggs, Mateja R. Savoie-Roskos, Lydia Bangerter, Casey Coombs

All Current Publications

Deciding how to feed an infant is a decision that should be made by a mother and her family. The benefits of exclusively breastfeeding an infant for the first six months of life are well established (World Health Organization [WHO], 2017); however, it may not always be feasible or a preferred option. For mothers who cannot or choose not to breastfeed, formula feeding is a great option that can support a healthy and thriving infant. This fact sheet will address common questions about breastfeeding and formula feeding to help mothers make an informed decision on how to feed their infant, …

Leptin’S Role In The Obesity Epidemic, Alyssa C. Washeleski

Honors College Theses

Weight loss methods have been around for decades, but yet, individuals still can’t lose weight or keep it off. Researchers have pondered if there is more to being incapable of losing body fat than individuals having a lack of willpower. While the environment plays a critical role in weight regulation, genetics may be just as important.

Research has discovered a hormone called leptin that controls energy expenditure and satiety. Leptin plays a part in many physiological roles, including appetite control, sexual function, immunity, insulin sensitivity, and the metabolism of lipid and bone. Studies done with mice and humans have concluded …

Increasing Patient Adherence To Gestational Weight Gain Goals In Pregnancy, Annie Vining

Dissertations

Abstract

Problem: The inability to maintain healthy weight gain during pregnancy may contribute to multiple pregnancy-related complications. Nutritional education and support may improve nutrition and vitamin consumption, and recommendations for healthy gestational weight gains have been published. However, pregnant women have reported minimal advice regarding healthy weight gain during pregnancy. A personalized, nutritional counseling program was initiated in a Midwestern, suburban OB-GYN private practice.

Methods: A quality improvement descriptive, correlational design was used. A cohort of pregnant women first trimester through six-weeks postpartum received individual counseling and face-to-face interaction at an office visit each trimester.

Results: Twenty ( …

The Impact Of Anthropometric Measurements On Lactate Levels At Rest And During Exercise, Ashley Kristine Edwards

Theses and Dissertations

49 Pages

Objective: The purpose of this study was to evaluate the relationship between anthropometric measures with heart rates (HR) at specific blood lactate concentrations [bLa] during exercise.

Method: Participants and data for this study were collected by an orthopedic rehabilitation center in Central Illinois. Participants underwent lactate testing following METHOD CRA protocol on an upright cycle and an optional DEXA scan. Heart rate values at Prime (2 mmol/L), Anaerobic (4 mmol/L) and Peak (6 mmol//L) blood lactate concentrations were recorded. Data was analyzed using Pearson correlations.

Results: A total of 59 participants were included. Participants ages ranged from 21 …

The Role Of Diet In The Onset Of Depression: A Biochemical Connection Between Nutrition And Mental Health, Katlin Wildeman

Senior Honors Theses

Depression is a major clinical concern, having a complex onset and the presence of multiple, often unidentifiable causes. Depression affects millions of individuals worldwide, with a high prevalence in regions of the world with a Western-style diet as compared to regions with a Mediterranean diet. A Western-style diet consists of foods high in sugar, fat, and processed meats and grains, whereas the Mediterranean diet contains significantly more vegetables, fruits, lean meats, and whole grains. The link between diet and mental health disorders has implications for individuals of all ages who are hesitant to turn to medication. In addition to presenting …

Effects Of Acute Dietary Polyphenols And Post-Meal Physical Activity On Postprandial Metabolism In Adults With Features Of The Metabolic Syndrome, Dustin W. Davis, James W. Navalta, Graham R. Mcginnis, Reimund Serafica, Kenneth Izuora, Arpita Basu

Kinesiology and Nutrition Sciences Faculty Research

Approximately 22% of U.S. adults and 25% of adults globally have metabolic syndrome (MetS). Key features, such as dysglycemia and dyslipidemia, predict type 2 diabetes, cardiovascular disease, premature disability, and death. Acute supplementation of dietary polyphenols and post-meal physical activity hold promise in improving postprandial dysmetabolism. To our knowledge, no published review has described the effects of either intervention on postprandial glucose, insulin, lipids, and markers of oxidative damage and inflammation in adults with features of MetS. Thus, we conducted this review of controlled clinical trials that provided dietary polyphenols from oils, fruits, teas, and legumes during a dietary challenge, …

Impact Of Health Promoting Nutrition Intervention Package On Severe Malnutrition Among Under-Five Children In Rural Northern India, Poonam Khanna, Tejinder P. Singh, Rajbir Kaur, Jill Miller, Thakur Mejie, Sonia Minhas, Jyoti Dixit, Manoj Sharma

Environmental & Global Health Faculty Research

Globally, 17 million children under 5 years of age are affected with severe malnutrition. Severe wasting is a key contributor (12.6%) to child deaths due to nutritional deficiencies and is responsible for several morbid conditions. The purpose of this paper was to assess the impact of nutritional counseling intervention on severe malnutrition among rural under-five children in Northern India. Nine villages in an ongoing project were included in the study to include all the under-five children (N=573) from these villages. Nutritional assessment was performed as per World Health Organization (WHO) child growth standards. Based on their z-scores of malnourishment indicators, …

The Effects Of Nutrition Smartphone Applications On Parents’ Grocery Shopping And Meal Planning Behaviors, Lacey Bertram

Theses and Dissertations

The purpose of this experimental research study was to determine the effects that nutrition smartphone applications, specifically grocery list generation applications, have on parents’ overall grocery shopping experience and meal planning behaviors for their families. The prevalence of adolescent obesity in today’s society has significantly increased to an alarming rate and family mealtimes together have decreased. Family mealtimes together can impact a child’s weight status and future health outcomes. A total of 10 participants investigated and classified the aspects in a nutrition smartphone application that were beneficial to meal planning and grocery shopping. The findings indicated that a nutrition smartphone …

Orthorexia Nervosa In College Students: Eating Disorder History, Gender, And Dieting Behaviors, Katrina Agger, Brittany Moran, Zhiping Yu Phd, Rnd, Ldn

Showcase of Osprey Advancements in Research and Scholarship (SOARS)

Objective: College students are at higher risk for the development of orthorexia nervosa (ON), a term used to describe the pathological obsession with healthy eating. This study aimed to assess how the factors of eating disorder (ED) history, gender, and dieting behaviors affect the ON in this population.

Methods: Students 18 years or older in a southeastern university were invited to take an online survey. Survey questions include Bratman Orthorexia Test (BOT), Eating Attitude Test-26 (EAT-26) and participant characteristics.

Results: 411 students (ages 18-65, BMI 15.1-55.5, female 75.2%, white 75.6%, graduate students 16.1%) have completed the survey. Comparing to students …

Food Insecurity As A Continuum: Investigating The Emotional Well-Being Of Parents, Monquie Villamor, Jody Nicholson-Bell, Lauri Wright

Showcase of Osprey Advancements in Research and Scholarship (SOARS)

Household food insecurity is one of the United States’ leading public health concerns that affects millions of families every year. Current literature has mainly focused on the impact of food insecurity on multidimensional outcomes of children (Jyoti et al., 2005; Shankar et al., 2017). However, there is limited research on parents’ experiences and the distinct levels of food insecurity outlined by the USDA. The present study investigates parents’ emotional well-being in association with levels of food insecurity and participation in food assistance programs. It is hypothesized that increased severity of food insecurity will be associated with poorer emotional well-being in …