Human and Clinical Nutrition Commons^™

Hemodialysis Care Staff Perceptions On Barriers To Optimal Health: Results From A Qualitative Study And National Survey, Daniela A. Gutierrez More

Graduate Theses

Chronic Kidney Disease (CKD) is currently the ninth leading cause of death in the United States, and despite the favorable outcomes reported in previous studies, mortality rates for CKD have yet to show improvement. The purpose of this study was distinguish between the different strategies used to treat CKD as perceived by renal practitioners. It is hypothesized that the lack of improvement in mortality rates may be attributed to the lack of cardiovascular protection.

The Association Between Fruit And Vegetable Consumption And Mental Health Among Young Adults, Natalie Miller

Human Nutrition and Hospitality Management Undergraduate Honors Theses

While the majority of the American population is aware that fruits and vegetables can improve physical health, research also suggests that mental health may benefits as well. With depression and anxiety rates increasing and fruit and vegetable consumption decreasing across the country there is potential that the two are related. It has been found that majority of American adults do not meet fruit and vegetable recommendations, while 16 million adults face depression and anxiety. Young adults reported the lowest amount of fruit and vegetable consumption, as well as some of the highest rates of depression and anxiety. The purpose of …

An Examination Of The Relationship Between Child Iq And Diet Quality, Carly Sheffer

Renée Crown University Honors Thesis Projects - All

The objective of this study was to evaluate the relationship between diet quality and intelligence quotient (IQ) in children who participated in the Syracuse Lead Study. The sample consisted of 266 African-American and Caucasian children ages 9 to 11 years old living in the city of Syracuse. Participants completed 2 days of dietary recalls and Healthy Eating Index-2015 scores were calculated to determine diet quality. Parent and child IQ were measured by the Kaufman Brief Intelligence Test. Seafood and plant protein intake was the only dietary component that significantly predicted a higher child IQ. Better HEI scores for fatty acids, …

Redesign, Field-Testing, And Validation Of The Physical Activity Campus Environmental Supports (Paces) Audit., Tanya M. Horacek, Elif Dede Yildirim, Dean Seidman, Carol Byrd-Bredbenner, Sarah E. Colby, Adrienne A. White, Karla P. Shelnutt, Melissa D. Olfert, Anne E. Matthews, Kristin Riggsbee, Lisa Franzen-Castle, Jesse Stabile Morrell, Kendra Kattelmann

Health and Nutritional Sciences Faculty Publications

This paper describes the redesign, field-testing, and convergent validity of a practical tool-Physical Activity Campus Environmental Supports (PACES) audit. Methods. The audit includes two parts: (1) PACES-Programs, which is comprised of questions regarding populations served, fees, programs (recreation/fitness classes and intramurals), proximity, adequacy of facilities, and marketing, and (2) PACES-Facilities, which is comprised of questions regarding built environment (aesthetics, bike racks, stairs, and universal design), recreation equipment, staff, amenities, and access. Each item criterion is specifically scored using a five-point, semantic-differential scale ranging from limited to extensive environmental support. A few questions utilize select all that apply for a summed …

The Acute Effects Of Citrulline Malate And Bonded Arginine Silicate Supplementation On Vasodilation Of Young Adults, Jeffrey Rogers

Health, Human Performance and Recreation Undergraduate Honors Theses

Abstract

Background

Clinicians, professional athletes, and recreational athletes are interested in supplementation that up-regulates nitric oxide (NO) production in blood vessel endothelium, increasing arterial vasodilation. Benefits from these supplements include improvements in blood pressure, muscle hyperemia, and exercise performance. Citrulline Malate (CM) is a pre-workout ingredient, popular for its ability to increase exercise performance and blood serum concentrations of L-arginine, resulting in NO production. Recently, Inositol-Stabilized Arginine Silicate (ASI, Nitrosigine) has been added to many of the most popular pre-workout blends, following a group of studies showing ASI increases serum arginine and reduces post-workout muscle damage. Research has yet to …

Effects Of An Educational Intervention On Nutrition And Healthy Eating Habits In Minority Group Parents And Children Living In Arkansas, Peri Clay

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: The Hispanic population is the largest growing minority ethnic group in the United States today. Minority groups have an added struggle with obesity and have higher rates of obesity in this country than the caucasian counterparts. While minority group parents want more for their children they face many cultural and language barriers related to proper nutrition and hydration. This prevents these families from gaining adequate nutrition.

Objective: The purpose was to evaluate the impact of nutrition education on obesity rates through implementation of a year long educational intervention for minority group mothers and their children through and …

Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant

Graduate Theses and Dissertations

As individuals enter adulthood, their lifestyles and lifestyle behaviors begin to change drastically. These lifestyle behavior changes in emerging adulthood provide a foundation for future health behaviors that often persist through all of adulthood. The aim of this study was to use Latent profile analyses (LPA) to discover distinct profiles of homogenous groups of young adults based on alcohol, diet, and exercise behaviors. Overall, five distinct profiles for both males and females were identified: Moderates, Unhealthy Eaters, Medium Drinkers, Healthier Eaters and Exercisers, and Heavy Drinkers. Heavy Drinkers and Unhealthy Eaters were the highest risk groups and reported the highest …

Bovine Milk Extracellular Vesicles (Evs) Modification Elicits Skeletal Muscle Growth In Rats, Hailey A. Parry, C. Brooks Mobley, Petey W. Mumford, Matthew A. Romero, Cody T. Haun, Yufeng Zhang, Paul A. Roberson, Janos Zempleni, Arny A. Ferrando, Ivan J. Vechetti, John J. Mccarthy, Michael D. Roberts, Andreas N. Kavazis

Department of Nutrition and Health Sciences: Faculty Publications

The current study investigated how bovine milk extracellular vesicles (EVs) affected rotarod performance and biomarkers of skeletal muscle physiology in young, growing rats. Twenty-eight-day Fisher 344 rats were provided an AIN-93G-based diet for 4 weeks that either remained unadulterated [EVs and RNA-sufficient (ERS; n = 12)] or was sonicated [EVs and RNA-depleted (ERD; n = 12)]. Prior to (PRE) and on the last day of the intervention (POST), animals were tested for maximal rotarod performance. Following the feeding period, the gastrocnemius muscle was analyzed at the histological, biochemical, and molecular levels and was also used to measure mitochondrial function and …

Cooking Frequency Associated With Dietary Quality In Icook-4h Youth Participants At Baseline, Amber D. Ford, Sarah E. Colby, Marissa Mcelrone, Lisa Franzen-Castle, Melissa D. Olfert, Kendra K. Kattelmann, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

Background: Increased intakes of ready-made and fast foods paralleled with decreased homemade food consumption have been associated with increased rates of obesity. Researchers have shown associations between cooking self-efficacy (SE) and cooking frequency (CF) with dietary quality and weight status. Some cooking interventions have shown positive associations with dietary outcomes, such as increased fruit and vegetable intake and decreased fast food consumption. There is still much unknown about SE and CF, especially among youth.
Objective: Determine baseline SE and CF and the associations with dietary quality and body mass index (BMI) of youth enrolled in iCook 4H.
Methods: Youth (n=228, …

Is Breastfeeding Truly Best? Evolutionary, Physiological, & Cultural Factors That Shape Breastfeeding Practices, Emily J. Green 19

Honor Scholar Theses

No abstract provided.

The Effects Of Highlighting Healthy Options On Consumer Food Choices In A Food Bank Setting, Kaitlin Nicole Grabow

Theses and Dissertations

Objective: The purpose of this study was to determine the effects of highlighting healthy food options on consumer food choices in a food bank setting.

Methods: Two community food banks participated in this study. One food bank served as the control, while a second food bank was rearranged so that fresh produce and other healthy products were the first options that shoppers encountered upon entering. After shopping, carts were inventoried for healthy vs non-healthy products. Composition of the carts from the control food bank were then compared to the contents of the carts from the intervention food bank.

Results: A …

Fiber Intake In Hemodialysis Patients And Its Effects On Symptoms, Jennifer Langner

Theses and Dissertations

On average 30 million adults are diagnosed with chronic kidney disease (CKD) in the United States (National Kidney Foundation, 2017). Patients in late stage kidney disease and on dialysis are placed on a restrictive diet to aid in the treatment of their disease. There are adverse symptoms associated with dialysis including nausea, constipation, diarrhea and fatigue. Fiber has been shown to decrease gastrointestinal symptoms such as reducing constipation and inflammation in the body in healthy populations. This study examined 19 hemodialysis dialysis patients and their fiber intake in relation to a variety of symptoms such as constipation, nausea, vomiting, diarrhea, …

Hydration Knowledge And Intake In High School Student Athletes, Erin Ortiz

Theses and Dissertations

Objective: Heat related illness is one of the leading causes of death in high school athletes.

Proper hydration strategies have been shown to decrease heat related illness in college and

professional athletes. However, limited research has been conducted on the hydration habits of

high school athletes. The increase in high school sports participation has put more athletes at

risk for dehydration. The purpose of the study is to investigate the hydration status and impact of

an educational intervention on hydration habits of high school student athletes, by assessing their

current understanding of hydration and monitoring their fluid intake, during practice. …

Development And Validation Of The Policies, Opportunities, Initiatives And Notable Topics (Points) Audit For Campuses And Worksites, Tanya M. Horacek, Marlei Simon, Elif Dede Yildirim, Adrienne A. White, Karla P. Shelnutt, Kristin Riggsbee, Melissa D. Olfert, Jesse Morrell, Anne E. Matthews, Wenjun Zhou, Tandalayo Kidd, Kendra Kattelmann, Geoffrey Greene, Lisa Franzen-Castle, Sarah E. Colby, Carol Byrd-Bredbenner, Onikia Brown

Department of Nutrition and Health Sciences: Faculty Publications

Background: Workplace or campus wellness/obesity-prevention policies and initiatives can improve health. Research tools to assess worksite or campus policies/initiatives are scarce. Thus, the aim of this research is to develop and validate the policies, opportunities, initiatives, and notable topics (POINTS) audit. Methods: POINTS was developed and refined via expert review, pilot-testing, and field testing. Trained researchers completed a web-based review from a student-focus or employee-focus regarding 34 health-promoting topics for colleges. Each topic was evaluated on a 0–2 scale: 0 = no policy/initiative, 1 = initiatives, 2 = written policy. When a written policy was detected, additional policy support questions …

Development Of The Icook 4-H Curriculum For Youth And Adults: Cooking, Eating, And Playing Together For Childhood Obesity Prevention, Lisa Franzen-Castle, Sarah E. Colby, Kendra K. Kattelmann, Melissa D. Olfert, Douglas Mathews, Katheryn Yerxa, Barbara Baker, Michelle Krehbiel, Tracy Lehrke, Kimberly Wilson, Amber Ford, Trina Aguirre, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

The objective was to describe the development process of a curriculum (iCook 4-H) targeted to low-income, rural, and/or diverse youths and their adult primary meal preparer to promote cooking, eating, and playing together. Lessons learned highlighted the importance of grounding the curriculum in Social Cognitive Theory and applying the experiential 4-H learning model using a multiphased, community-based participatory approach with cyclical development and evaluation, and key modifications made for dissemination and distribution. Findings across 4 testing phases over 6 years and 5 states demonstrated the time-intensive, cyclical process that required flexibility with fidelity to form a hands-on, interactive curriculum.

Ethiopia’S High Childhood Undernutrition Explained: Analysis Of The Prevalence And Key Correlates Based On Recent Nationally Representative Data, Tafere Gebreegziabher Belay, Nigatu Regassa

All Faculty Scholarship for the College of the Sciences

Objective

To examine the contribution of child, maternal and household factors in stunting, wasting and underweight among children under 5 years in Ethiopia. Design

Quantitative cross-sectional design based on nationally representative data. Setting

Urban and rural areas of Ethiopia. Participants

Younger (0–24 months; n 4199) and older age groups (25–59 months; n 5497), giving a total of 9696 children. Results

Among the younger age group, 29 % were stunted, 14 % were wasted and 19 % were underweight; and among the older age group, the prevalence of stunting, wasting and underweight was 47, 8 and 28 %, respectively. Being female, …

An Iterative Process For Training Design And Implementation Increased Health Workers' Knowledge For Taking Nutrition Behavior Change To Scale, Wendy Gonzalez, Anabelle Bonvecchio Arenas, Armando García-Guerra, Mireya Vilar-Compte, Alejandría Villa De La Vega, Laura Quezada, Cynthia Rosas, Ana Lilia Lozada-Tequeanes, Amira Hernández

Department of Public Health Scholarship and Creative Works

The shortage of skilled, motivated, and well-supported health workers is a major barrier to scaling up nutrition interventions and services. Objective: The objective of this study is to describe the process for developing and implementing a training of health personnel for the delivery of the Integrated Strategy for Attention to Nutrition (EsIAN), an evidence-based strategy for promoting infant and young child feeding through primary health care in Mexico. The specific objective is to provide a case study and highlight challenges, as well as elements to successfully mitigate these, and discuss potential applications of findings beyond the Mexican context. Methods: The …

Dietary Polyphenols And Their Perceived Health Benefits, Stephanie Russell

Honors Program: Senior Projects (Public)

This paper will consist of a compilation of information on polyphenol classes, dietary sources, and potential health benefits. Polyphenols can be classified as flavonoids, phenolic acids, lignans, or stilbenes. These molecules consist of over 500 plant metabolites that come from numerous food sources including various fruits, vegetables, grains, and beverages such as coffee, tea, and wine. The quantity of polyphenols in food vary greatly, as does their bioavailability for use in the body after consumption. Due to antioxidant and anti-inflammatory properties, polyphenols are being studied for effects on reducing the risk of cardiovascular disease. This paper will focus on structural …

Maternal Choline Supplementation Modulates Placental Markers Of Inflammation, Angiogenesis, And Apoptosis In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Xinyin Jiang, Vladislav G. Fomin, Samantha P. Levine, Emily Wei, Mark S. Roberson, Marie A. Caudill

Publications and Research

Dlx3 (distal-less homeobox 3) haploinsufficiency in mice has been shown to result in restricted fetal growth and placental defects. We previously showed that maternal choline supplementation (4X versus 1X choline) in the Dlx3+/�� mouse increased fetal and placental growth in mid-gestation. The current study sought to test the hypothesis that prenatal choline would modulate indicators of placenta function and development. Pregnant Dlx3+/�� mice consuming 1X (control), 2X, or 4X choline from conception were sacrificed at embryonic (E) days E10.5, E12.5, E15.5, and E18.5, and placentas and embryos were harvested. Data were analyzed separately for each gestational day controlling for litter …

Development And Validation Of The Vending Evaluation For Nutrient-Density (Vend)Ing Audit., Tanya M Horacek, Elif Dede Yildirim, Melissa Matthews Schreiber, Carol Byrd-Bredbenner, Sarah E. Colby, Adrienne A White, Karla P. Shelnutt, Melissa D. Olfert, Anne E Mathews, Kristin Riggsbee, Lisa Franzen-Castle, Jesse Morrell, Kendra Kattelmann

Health and Nutritional Sciences Faculty Publications

Background: This paper describes the development and validation of the Vending Evaluation for Nutrient-Density (VEND)ingaudit to comprehensively evaluate vended products based upon healthfulness, price and promotion, and machine accessibility. Methods: A novel vending nutrient-density score was created to determine the healthfulness of vended snack/beverage products. Field tested in United States colleges, VENDing audit (∑nutrient-density + 10 × % healthy products) and Support sub-scores (price + promotion + accessibility) were calculated for snack/beverage machines. Higher scores indicate more healthful vending options and supports for choosing healthfully. Nutrition Environment Measures Survey-Vending (NEMS-V) was used to validate the nutrient-density score for a sub-sample …

Cooking Frequency Associated With Dietary Quality In Icook-4h Youth Participants At Baseline, Amber D. Ford, Sarah E. Colby, Marissa Mcelrone, Lisa Franzen-Castle, Melissa D. Olfert, Kendra K. Kattelmann, Adrienne A. White

Department of Nutrition and Health Sciences: Faculty Publications

Background: Increased intakes of ready-made and fast foods paralleled with decreased homemade food consumption have been associated with increased rates of obesity. Researchers have shown associations between cooking self-efficacy (SE) and cooking frequency (CF) with dietary quality and weight status. Some cooking interventions have shown positive associations with dietary outcomes, such as increased fruit and vegetable intake and decreased fast food consumption. There is still much unknown about SE and CF, especially among youth.

Objective: Determine baseline SE and CF and the associations with dietary quality and body mass index (BMI) of youth enrolled in iCook 4H.

Methods: Youth (n …

Micrornas In Bovine Milk Exosomes Are Bioavailable In Humans But Do Not Elicit A Robust Pro-Inflammatory Cytokine Response, Ezra Mutai, Amanda E. Ramer-Tait, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Background: Bovine milk exosomes are studied for their roles as bioactive food compounds and as vehicles for drug delivery. Both lines of investigation converge on immune function, e.g., immune regulation by absorption of microRNAs encapsulated in milk exosomes across species boundaries, and the possibility of exosomes and their cargos triggering an immune response if used in drug delivery. This study assessed the bioavailability of immune-related microRNAs from bovine milk and changes in plasma cytokine concentrations after milk consumption in humans, and the secretion of cytokines by human peripheral blood mononuclear cells (PBMCs) cultured with milk exosomes transfected with immune-relevant microRNAs. …

Effects Of Red Raspberry Polyphenols And Metabolites On Biomarkers Of Inflammation And Insulin Resistance In Prediabetes And Type 2 Diabetes, Reynaldo Moreno Ucles

LSU Doctoral Dissertations

Berry fruits are rich sources of polyphenolic compounds (PCs), which can promote health benefits. Anthocyanin concentrations of red raspberry (RR)(Rubus idaeus) extracts were determined to be a total of 887.6 ± 262.8 μg/g cyanidin-3-sophoroside (C3S) equivalents with C3S being the most prevalent. Ellagitannin analysis by MALDI-TOF indicated sanguiin H-6 and lambertianin C were the major ellagitannins present in RR. To explore the efficacy of RR in modulating diabetes, seven type 2 diabetes mellitus (T2DM) and two pre-diabetic patients were given drinks delivering one RR serving (123 g) per day in a smoothie for two weeks. Blood samples were …

Cooking And Meal Planning As Predictors Of Fruit And Vegetable Intake And Bmi In First-Year College Students, Andrea J. Hanson, Kendra K. Kattleman, Lacey A. Mccormack, Wenjun Zhou, Onikia N. Brown, Tanya M. Horacek, Karla P. Shelnutt, Tandalayo Kidd, Audrey Opoku-Acheampong, Lisa D. Franzen-Castle, Melissa D. Olfert, Sarah E. Colby

Faculty & Staff Scholarship

The objective was to determine if cooking skills and meal planning behaviors are associated with greater fruit and vegetable intake and lower body mass index (BMI) in first-year college students who are at risk for excessive weight gain. A cross-sectional analysis was conducted using baseline data from a multi-state research project aimed at preventing weight gain in first-year college students. Cooking type, frequency and confidence, self-instruction for healthful mealtime behavior intention, self-regulation of healthful mealtime behavior, and cup equivalents of fruits and vegetables (FV) were measured using validated surveys. BMI was calculated from measured height and weight. First-year students (n …

Tanglewood Trail Walking And Voucher Program, Kelci Marie Mchugh

Theses and Dissertations--Nutrition and Food Systems

Rural Appalachian populations have greater rates of obesity and chronic diseases attributed to lesser consumption of fruits and vegetables (F/V) and physical inactivity. Barriers to F/V consumption and physical activity include poor access and affordability. To help overcome these barriers, a community-initiated walking and farmers market F/V voucher program was implemented.

Participants were encouraged to walk (1.2 miles roundtrip) to the local farmers market to redeem a $10 voucher which could only be spent on F/V. The 16-week program (June – Sept) included 121 participants. Data was analyzed by creating two groups, low-engagers and high-engagers that differed significantly in the …

State Population Influences Athletic Performance Combine Test Scores In High School-Aged American Football Players, Zachary M. Gillen, Marni E. Shoemaker, Brianna D. Mckay, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

This study compared athletic performance differences among high school American football combine participants originating from states of different population sizes. High school-aged American football players (n=7,214) who had participated in athletic performance combines between March 2015 and January 2016 were included in this analysis. Data included combine date and location, school state of origin, football position, class, height, weight, 10-, 20-, and 40-yd dash times, pro-agility, L-cone drill, vertical jump, broad jump, and power push-up. Participants were separated into high- (state population>10,000,000; HIGH; n=2,804), mid- (state population=5,000,000-9,999,999; MID; n=2,911), or low-population (state population<5,000,000; LOW; n=1,499) state of origin. Data were allometrically scaled to account for differences in body mass across high school grade levels and American football positions. All statistical analyses were performed on the allometrically scaled data. LOW athletes performed better than HIGH athletes in the 20-yd dash (p≤0.01). LOW athletes performed better than HIGH and MID in the 40-yd dash, proagility, broad jump, and power push-up (p<0.01). LOW and HIGH athletes performed better than MID in the Lcone and vertical jump (p<0.01). When considering population size, athletes originating from LOW states may demonstrate higher levels of athletic performance in football combine events hypothetically due to more opportunities for sports participation and playing time, leading to greater athletic development. Youth and high school coaches in MID and HIGH states might consider providing more opportunities for playing and individualized coaching to encourage long-term athletic development.

Development And Validation Of The Vending Evaluation For Nutrient-Density (Vend)Ing Audit, Tanya M. Horacek, Elif Dede Yildirim, Melissa Matthews Schreiber, Carol Byrd-Bredbenner, Sarah E. Colby, Adrienne A. White, Karla P. Shelnutt, Melissa D. Olfert, Anne E. Matthews, Kristin Riggsbee, Lisa Franzen-Castle, Jesse Stabile Morrell, Kendra Kattelmann

Department of Nutrition and Health Sciences: Faculty Publications

Background: This paper describes the development and validation of the Vending Evaluation for Nutrient-Density (VEND)ing audit to comprehensively evaluate vended products based upon healthfulness, price and promotion, and machine accessibility. Methods: A novel vending nutrient-density score was created to determine the healthfulness of vended snack/beverage products. Field tested in United States colleges, VENDing audit (Σnutrient-density + 10 x % healthy products) and Support sub-scores (price + promotion + accessibility) were calculated for snack/beverage machines. Higher scores indicate more healthful vending options and supports for choosing healthfully. Nutrition Environment Measures Survey-Vending (NEMS-V) was used to validate the nutrient-density score for a …

Development And Validation Of The Policies, Opportunities, Initiatives And Notable Topics (Points) Audit For Campuses And Worksites, Tanya M. Horacek, Marlei Simon, Elif Dede Yildirim, Adrienne A. White, Karla P. Shelnutt, Kristin Riggsbee, Melissa D. Olfert, Jesse Stabile Morrell, Anne E. Matthews, Wenjun Zhou, Tandalayo Kidd, Kendra Kattelmann, Geoffrey Greene, Lisa Franzen-Castle, Sarah E. Colby, Carol Byrd-Bredbenner, Onikia Brown

Department of Nutrition and Health Sciences: Faculty Publications

Background: Workplace or campus wellness/obesity-prevention policies and initiatives can improve health. Research tools to assess worksite or campus policies/initiatives are scarce. Thus, the aim of this research is to develop and validate the policies, opportunities, initiatives, and notable topics (POINTS) audit. Methods: POINTS was developed and refined via expert review, pilot-testing, and field testing. Trained researchers completed a web-based review from a student-focus or employee-focus regarding 34 health-promoting topics for colleges. Each topic was evaluated on a 0–2 scale: 0 = no policy/initiative, 1 = initiatives, 2 = written policy. When a written policy was detected, additional policy support questions …

The Validity Of The Emg And Mmg Techniques To Examine Muscle Hypertrophy, Ethan C. Hill, Terry J. Housh, Josh L. Keller, Cory M. Smith, Richard Schmidt, Glen O. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

Objective: The purpose of this investigation was to examine the ability of the electromyographic (EMG) and mechanomyographic (MMG) amplitude versus torque relationships to track group and individual changes in muscle hypertrophy as a result of resistance training.

Approach: Twelve women performed four weeks of forearm flexion blood flow restriction (BFR) resistance training at a frequency of three times per week. The training was performed at an isokinetic velocity of 120°∙s⁻¹ with a training load that corresponded to 30% of concentric peak torque. Muscle hypertrophy was determined using ultrasound-based assessments of muscle cross-sectional area from the biceps …

Urolithin A, A Gut Metabolite, Improves Insulin Sensitivity Through Augmentation Of Mitochondrial Function And Biogenesis, Ashley Mulcahy Toney, Rong Fan, Yibo Xian, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung

Department of Nutrition and Health Sciences: Faculty Publications

Objective: Urolithin A (UroA) is a major metabolite of ellagic acid produced following microbial catabolism in the gut. Emerging evidence has suggested that UroA modulates energy metabolism in various cells. However, UroA’s physiological functions related to obesity and insulin resistance remain unclear. Methods: Male mice were intraperitoneally administrated either UroA or dimethyl sulfoxide (vehicle) along with a high-fat diet for 12 weeks. Insulin sensitivity was evaluated via glucose and insulin tolerance tests and acute insulin signaling. The effects of UroA on hepatic triglyceride accumulation, adipocyte size, mitochondrial DNA content, and proinflammatory gene expressions were determined. The impact of UroA on …