Nutrition Commons^™

A Review Of The Effects Of Dietary Restriction, Dehydration, And Caffeine Withdrawal On Cognition: Implications For A Disabled Submarine Scenario, Sarah Chabal

Journal of Human Performance in Extreme Environments

In the event that submariners become trapped aboard a disabled submarine (DISSUB), they must perform a multitude of cognitively demanding tasks in order to maximize their likelihood of survival. During this time, submariners will also be forced to endure poor living conditions, including drastic changes to their nutrition. These nutritional changes have the potential to impair submariners’ cognitive functioning and affect operational performance, which could jeopardize survival; however, the effects of DISSUB nutrition on cognitive performance are not well understood. This review first describes the unique nutritional conditions that submariners will experience in a DISSUB scenario, including the change to …

“We’Re, Like, The Most Unhealthy People In The Country”: Employing An Equity Lens To Reduce Barriers To Healthy Food Access In Rural Appalachia, Kathryn Cardarelli, Emily M. Dewitt, Rachel Gillespie, Heather Norman-Burgdolf, Natalie Jones, Janet Tietyen Mullins

Dietetics and Human Nutrition Faculty Publications

Introduction

Obesity disproportionately affects rural communities, and Appalachia has some of the highest obesity rates in the nation. Successful policy, systems, and environmental (PSE) interventions to reduce obesity must reflect the circumstances of the population. We used a health equity lens to identify barriers and facilitators for healthy food access in Martin County, Kentucky, to design interventions responsive to social, cultural, and historical contexts.

Methods

We conducted 5 focus groups in Martin County, Kentucky, in fall 2019 to obtain perspectives on the local food system and gauge acceptability of PSE interventions. We used grounded theory to identify perceived barriers and …

Effects Of Consuming Sugar-Sweetened Beverages For 2 Weeks On 24-H Circulating Leptin Profiles, Ad Libitum Food Intake And Body Weight In Young Adults, Desiree M. Sigala, Adrianne M. Widaman, Bettina Hieronimus, Marinelle V. Nunez, Vivien Lee, Yanet Benyam, Andrew A. Bremer, Valentina Medici, Peter J. Havel, Kimber L. Stanhope, Nancy L. Keim

Faculty Research, Scholarly, and Creative Activity

Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18–35 kg/m2; 18–40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = 23–28/group). Body weight, ad libitum food intake and 24-h leptin area under the curve (AUC) were assessed at Week 0 and at the end of Week …

The Association Of The Inflammatory Potential Of Diet With Inflammation And Depression Among U.S. Adults: Nhanes 2005-2010, Deniz Azarmanesh

Doctoral Dissertations

Depression affects 8% of adults in America. Women are twice as likely as men to experience depression. The economic burden in the U.S. is $83 billion in direct (e.g., pharmaceutical) and indirect costs (e.g., absenteeism from work). The etiology of depression includes non-modifiable (e.g., genetics) and modifiable risk factors (e.g., diet). Depression is concurrent with an increase in inflammatory biomarkers, such as c-reactive protein (CRP). Emerging research suggests that a pro-inflammatory diet may increase odds of experiencing depression. The Dietary Inflammatory Index (DII) assesses the inflammatory potential of diet. According to our narrative review of the current literature in Chapter …

Adsorptive Surface Modification Of Cellulose Nanocrystals To Stabilize Nutraceuticals Loaded Lipid Carriers For Food Application, Avinash S. Patel

Electronic Theses and Dissertations

Lipid carriers such as emulsions and liposomes have been widely studied as carriers for different nutraceuticals. However, lipid carriers' physicochemical instability results in the leakage of loaded nutraceuticals and the low solubility into the digestion medium, thus reducing the bioaccessibility. Cellulose nanocrystals (CNC) are nano-sized cellulose derivatives obtained after hydrolysis of cellulosic matrices that possess potential applications in functional foods and nutraceuticals. However, hydrophilicity, anionic surface potential, and poor re-dispersibility limit CNC’s applications. The primary objectives of this research were 1) to modify CNC via adsorbing polyethylene glycol (PEG) to stabilize liposomes and to study its physiochemical stability at different …

Brain Α-Tocopherol Concentration Is Inversely Associated With Neurofibrillary Tangle Counts In Brain Regions Affected In Earlier Braak Stages: A Cross-Sectional Finding In The Oldest Old, J. Tanprasertsuk, T.M. Scott, M.A. Johnson, L.W. Poon, P.T. Nelson, A. Davey, J.L. Woodard, R. Vishwanathan, A.K. Barbey, K. Barger, X.-D. Wang, E.J. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: Higher vitamin E status has been associated with lower risk of Alzheimer’s disease (AD). However, evidence of the association of vitamin E concentration in neural tissue with AD pathologies is limited. Design: The cross-sectional relationship between the human brain concentrations of α- and γ-tocopherol and the severity of AD pathologies – neurofibrillary tangle (NFT) and neuritic plaque (NP) – was investigated. Setting & Participants: Brains from 43 centenarians (≥ 98 years at death) enrolled in the Phase III of the Georgia Centenarian Study were collected at autopsy. Measurements: Brain α- and γ-tocopherol concentrations (previously reported) …

Holidays And Healthy Choices, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Objectives:

Healthy holiday eating

Incorporating physical activity into the holiday season

Budget friendly healthy holiday ideas

Translating Evidence-Based Guidelines Into Practice—Are We Getting It Right? A Multi-Centre Prospective International Audit Of Nutrition Care In Patients With Foregut Tumors (Inform), Merran Findlay, Judith D. Bauer, Rupinder Dhaliwal, Marian De Van Der Schueren, Alessandro Laviano, Adrianne Widaman, Lisa Martin, Andrew G. Day, Leah M. Gramlich

Faculty Research, Scholarly, and Creative Activity

Malnutrition is highly prevalent in patients with foregut tumors comprising head and neck (HNC) and esophageal (EC) cancers, negatively impacting outcomes. International evidence-based guidelines (EBGs) for nutrition care exist; however, translation of research evidence into practice commonly presents considerable challenges and consequently lags. This study aimed to describe and evaluate current international nutrition care practices compared with the best-available evidence for patients with foregut tumors who are at high risk of malnutrition. A multi-centre prospective cohort study enrolled 170 patients commencing treatment of curative intent for HNC (n = 119) or EC (n = 51) in 11 cancer …

Power Ultrasonication Improves Tenderness And Proteolysis In Beef Steak During Aging, Chandler Stafford

Fall Student Research Symposium 2020

Among the eating qualities attributed to cooked meat, tenderness is considered an essential factor in dictating consumers' overall satisfaction and future purchase. Tenderness can be influenced by several extrinsic and intrinsic factors; however, the extent of postmortem proteolysis that occurs during meat aging is the main contributor to end-product tenderness. The process involves enzymatic degradation of key cytoskeletal proteins and the signaling of cellular apoptosis, which ultimately leads to the breakdown of muscles structural integrity, resulting in tenderization. The calcium-dependent calpain system, specifically calpain-1, has been recognized as the main protease involved in postmortem tenderization. In the presence of calcium, …

Mitochondrial Pyruvate Consumption Decreases Glycolytic Flux In Postmortem Muscle, Natalie Keele

Fall Student Research Symposium 2020

Mitochondrial pyruvate consumption decreases glycolytic flux in postmortem muscleColor, water-holding capacity and tenderness are important aspects of meat quality that are impacted by pH. The pH of meat is primarily determined by the amount of anaerobic glycolysis that occurs postmortem. As glycogen is degraded, it will produce ATP, pyruvate and hydrogen ions that acidify the meat, and this acidification process is essential for proper meat quality development. In the absence of oxygen, pyruvate is converted to lactate to restore NAD+ necessary for further glycolysis. In this state of anoxia, mitochondria are often ignored due to their reliance on oxygen to …

Belief, Virtue, And Illness In Late-Nineteenth Century Domestic Manuals, Anneka Walton

Fall Student Research Symposium 2020

The belief that one's health is a result of their behavior has persisted throughout much of history. At times, these beliefs were so direct as to blame any and all illness on the "sins" of the victim. In some ways, we still see these beliefs persist today. While we now understand many of the true causes of illness, we continue to believe that poor behaviors can result in poor health outcomes, and often treat people suffering from conditions they "brought on themselves" accordingly. The object of this research is to better understand how American societal beliefs of the causes of …

Cytokine Indicators Of Inflammation In Mice Fed A Western Type Diet, Emily Mortensen

Fall Student Research Symposium 2020

Colorectal cancer is currently the second leading cause of cancer-related deaths in the United States and is projected to cause 53,200 deaths during 2020. The risk of colon cancer increases by 8-20% in individuals who suffer from colitis, which is inflammation of the colon lining. Colitis is common in patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The development of colorectal cancer is complex and can be associated with dysbiosis of the gut microbiota, which has been shown to be affected by diet. Disruption of the gut microbiome can lead to the overgrowth of pathogenic bacteria …

Diet And Successful Aging, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Learning Objectives:

Define successful aging

Understand the components of successful aging

Learn diets and dietary patterns for successful aging

Physical activity and successful aging

Understanding Caffeine Vs. Kids, Cindy Nelson, Rachel Mcmaster

All Current Publications

Children enjoy numerous foods and drinks on a regular basis that contain caffeine: soda, chocolate candy, energy drinks, and so forth. In fact, almost 3 out of 4 children consume caffeine regularly (American Academy of Family Physicians, 2020). This is a concern because studies show caffeine can affect children and adults differently, and too much caffeine can have detrimental health effects on kids. This fact sheet defines caffeine, reviews its effects and risks, identifies popular foods containing caffeine, and how to reduce consumption of caffeine.

A Note From The Editor, Kristina Bross

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

This letter introduces issue five of volume one, Ideas magazine, featuring the work of Dr. Lindsay Bottoms, fencer and sports physiologist.

Relationship Between Disordered Eating Risk & Body Image Dissatisfaction Of Spirit Squad Members, Sarah Abdul Albandar

Graduate Theses

Background: Investigations into body image and disordered eating habits among aesthetic sports has shown that these athletes face pressures to be thin and to be a certain body type for their sport.

Research aim/question(s): This study sought to determine if disordered eating habits and body dissatisfaction were prevalent within this population, whether or not there is a relationship between body image and disordered eating, and to determine the current research gap on body image and disordered eating among cheerleaders and dancers.

Materials and Methods: Participants were 23 females including cheerleaders and dancers on the Spirit Squad as well as dance …

A Theacrine-Based Supplement Increases Cellular Nad+ Levels And Affects Biomarkers Related To Sirtuin Activity In C2c12 Muscle Cells In Vitro, Petey W. Mumford, Shelby C. Osburn, Carlton D. Fox, Joshua S. Godwin, Michael D. Roberts

Faculty Scholarship

There is evidence in rodents to suggest that theacrine-based supplements modulate tissue sirtuin activity as well as other biological processes associated with aging. Herein, we examined if a theacrine-based supplement (termed NAD3) altered sirtuin activity in vitro while also affecting markers of mitochondrial biogenesis. The murine C2C12 myoblast cell line was used for experimentation. Following 7 days of differentiation, myotubes were treated with 0.45 mg/mL of NAD3 (containing ~2 mM theacrine) for 3 and 24 h (n = 6 treatment wells per time point). Relative to control (CTL)-treated cells, NAD3 treatments increased (p < 0.05) Sirt1 mRNA levels at 3 h, as well as global sirtuin activity at 3 and 24 h. Follow-up experiments comparing 24 h NAD3 or CTL treatments indicated that NAD3 increased nicotinamide phosphoribosyltransferase (NAMPT) and SIRT1 protein levels (p < 0.05). Cellular nicotinamide adenine dinucleotide (NAD+) levels were also elevated nearly two-fold after 24 h of NAD3 versus CTL treatments (p < 0.001). Markers of mitochondrial biogenesis were minimally affected. Although these data are limited to select biomarkers in vitro, these preliminary findings suggest that a theacrine-based supplement can modulate select biomarkers related to NAD+ biogenesis and sirtuin activity. However, these changes did not drive increases in mitochondrial biogenesis. While promising, these data are limited to a rodent cell line and human muscle biopsy studies are needed to validate and elucidate the significance of these findings.

Effects Of Daily 24-Gram Doses Of Rice Or Whey Protein On Resistance Training Adaptations In Trained Males, Jessica M. Moon, Kayla M. Ratliff, Julia C. Blumkaitis, Patrick S. Harty, Hannah A. Zabriskie, Richard A. Stecker, Brad S. Currier, Andrew R. Jagim, Ralf Jäger, Martin Purpura, Chad M. Kerksick

Faculty Scholarship

Large (48-g), isonitrogenous doses of rice and whey protein have previously been shown to stimulate similar adaptations to resistance training, but the impact of consuming smaller doses has yet to be compared. We evaluated the ability of 24-g doses of rice or whey protein concentrate to augment adaptations following 8 weeks of resistance training.

The Energy Savings-Oxidative Cost Trade-Off For Migratory Birds During Endurance Flight, Scott R. Mcwilliams, Barbara J. Pierce, Andrea Wittenzellner, Lillie A. Langlois, Sophia Engel, John R. Speakman, Olivia Fatica, Kristen J. Demoranville, Wolfgang Goymann, Lisa Trost, Amadeusz Bryla, Maciej Dzialo, Edyta T. Sadowska, Ulf Bauchinger

Biology Faculty Publications

Elite human and animal athletes must acquire the fuels necessary for extreme feats, but also contend with the oxidative damage associated with peak metabolic performance. Here, we show that a migratory bird with fuel stores composed of more omega-6 polyunsaturated fats (PUFA) expended 11% less energy during long-duration (6 hr) flights with no change in oxidative costs; however, this short-term energy savings came at the long-term cost of higher oxidative damage in the omega-6 PUFA-fed birds. Given that fatty acids are primary fuels, key signaling molecules, the building blocks of cell membranes, and that oxidative damage has long-term consequences for …

Availability And Consumption Of Vitamin A Foods Among Southern Ethiopian And Zambian Primary Students, Trang Vuong

NUTR/GLST 498b: Global Research Experiences in Nutrition and Health

Purpose: Understand vitamin A food availability in open-air markets (OAM’s), and consumption of those foods by primary school children in southern Ethiopia/Zambia.

Methods: Conducted inventories of all consumable/potable items and interviewed 6-7th grade students about consumption of items with vitamin A.

Results: Students consumed most of the 14 vitamin A foods/items sold in OAM’s. Zambian students ate more liver, pumpkin, squash, watermelon, and wild fruits, while Ethiopian students almost never consumed squash, watermelon or wild fruits.

Conclusions: The availability of Vitamin A foods in Ethiopian and Zambian OAMs are varied; however, Zambian children reportedly eat more vitamin A foods. Nutrition …

Roles Of Select Cytochrome P450 Epoxygenases In Brown Adipogenesis, Katherine Marie Graham

Masters Theses

Brown adipose tissue (BAT) has recently emerged as a novel target for obesity treatment and prevention. Cytochrome P450 (CYP) epoxygenases, primarily CYP2J and CYP2C isoforms, produce epoxy fatty acids (EpFAs), which have been suggested to play important roles in the regulation of white adipogenesis and obesity. However, adipocyte-specific expression of CYP epoxygenases has not been extensively analyzed, and the roles of CYP epoxygenases in brown adipogenesis remain unexplored. In this study, we examined mRNA levels of Cyp2j and Cyp2c isoforms during murine and human brown and white adipocyte differentiation and in various adipose tissue depots of high-fat diet (HFD)-fed and …

Anti-Inflammatory Properties Of Blackberry Phenolic And Volatile Compounds, Pauline Morin

Graduate Theses and Dissertations

Berries are known for many health benefits including anti-inflammatory properties that lower risks of chronic diseases. These properties have been linked to high concentrations of phenolic compounds, especially anthocyanins. However, the present study hypothesized that volatiles could contribute to the berries’ bioactive properties. Thus, the objectives of this research are to profile the phenolic and volatile composition of 16 blackberry genotypes harvested at the Fruit Research Center of the University of Arkansas and to evaluate the antiinflammatory capacities of three selected genotypes on inflamed cells. Phenolic and volatile profiles were evaluated using chromatographic techniques. The three genotypes A2528T, A2587T and …

Ionic Mechanism Of Lysosomal Function And Cell Metabolism, Jian Xiong

Dissertations & Theses (Open Access)

Two Pore Channels (TPCs) are endolysosomal ion channels that are permeable to sodium and calcium. Defects in TPCs have been implicated to impair vesicle trafficking, autophagy and cell metabolism control; however, the detailed mechanism remains largely unknown. In this study, I show that TPCs are critical for appropriate cargo delivery to the lysosomes and deletion of either TPC1 or TPC2 leads to delayed clearance of autophagosomes, resulting in enlarged lysosomes and accumulated contents inside the lysosomes. Cells with both TPC deleted also exhibit 50% reduction in lysosomal amino acids under normal culture conditions, leading to reduced homeostatic mTORC1 activation.

Glutamine …

The Effect Of Epa And Dha On Skeletal Muscle Physiology And Energy Balance, Saeed Jebor Ghnaimawi

Graduate Theses and Dissertations

Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) supplementation commonly suggested during pregnancy confers many health benefits on offspring and more recently improves fetal BAT development and induces myoblast trans-differentiation into adiopocytes through activating PPARs expression. Embryonic myoblast is a highly flexible cell showing great capacity to change its phenotype into adipocyte in response to EPA and DHA supplementation in many in vitro models. However, a little is known about the identity of derived adipocytes, whether, they change into brown or white adipocyte, and in vivo evidence is still missing. Given that the myogeneis process is initiated at the mid of …

Dietary Regulation Of Successful Aging, Aubree L. Hawley

Graduate Theses and Dissertations

The current growth of the older population is unprecedented in U.S. history. Chronic disease and functional limitation commonly develop prior to old age, leading to prolonged physical disability and decreased well-being. The development of chronic disease and loss of independence is associated with lean body mass (LBM) loss and fat mass gain beginning in middle age. Therefore, it is important to identify modifiable factors to mitigate deleterious shifts in body composition to promote successful aging (SA). The concept of SA is associated with longevity, the absence of disease and disability, and subjective components of well-being, however, an operational definition has …

Effects Of Commercial Feed Additives On Growth Performance And Gut Microbiota Of Nursery Pigs, Xiaoyuan Wei

Graduate Theses and Dissertations

To secure animal welfare and maximum production, feed additives are often added to nursery pig diets to increase nutrition digestibility, enhance intestinal health, and prevent or mitigate disease, with the ultimate goal of improving growth performance. This thesis performed a longitudinal analysis using next-generation sequencing to investigate the dynamic changes of gut microbiota in weaned pigs fed commercial feed additives. Chapter II was used to evaluate the effects of organic acid mixture on growth performance and gut microbiota of weaning pigs. This study demonstrated that the inclusion of 0.035% (SBA0.035) or 0.070% (SBA0.070) sodium butyrate in a diet containing 0.5% …

Antioxidant Properties And Anti-Cancer Effects Of Polyphenols In Sweetpotato Leaves, Josue Bolanos

Graduate Theses and Dissertations

Although the root is widely consumed, sweetpotato leaves (SPL) are often discarded and are only consumed in a few countries. In the United States, SPL consumption is limited to private gardens, particularly in the Southeastern United States. Not only are SPL a good source of nutrients such as vitamins and minerals, but they also contain polyphenol compounds including the caffeoylquinic acid derivatives and carotenoids such as lutein. Several studies have shown the polyphenol contents and antioxidant capacities of SPL, which vary based on year and variety, while few studies have shown anti-colon cancer effects of SPL. Therefore, this study investigated …

Vegetarian And Vegan Eating Patterns, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

Objectives:

Different types of vegetarian diets.

Identifying challenges vegetarians may experience

Protein complementation

Compare and contrast the dietary recommendations

Qualitative Analysis Of Maternal Barriers And Perceptions To Participation In A Federal Supplemental Nutrition Program In Rural Appalachian North Carolina, Sydeena E. Isaacs, Lenka H. Shriver, Lauren Haldeman

Journal of Appalachian Health

Background: Little is known about barriers to and perceptions of participation in the in Women, Infants, and Children (WIC) program in rural Appalachia.

Purpose: To gain a deeper understanding of maternal barriers and perceptions related to WIC participation in rural Appalachia

Methods: Pregnant women and mothers were recruited in-person and via flyers from WIC offices in three counties in Appalachian North Carolina. Four semi-structured focus groups were conducted between May to July 2018. Each focus group was approximately 60 minutes long and included open-ended questions about the overall WIC experience in rural Appalachia. Focus groups were audio-recorded, transcribed verbatim, and …

Referring Patients With Type 2 Diabetes To A Registered Dietitian Nutritionist In New Mexico, Rebecca A. Lamoreux

Individual, Family, and Community Education ETDs

Prevalence of Type 2 Diabetes (T2DM) in New Mexico (NM) has steadily increased to 12.5% in 2019.¹Registered Dietitian Nutritionists (RDNs) play a critical role in the T2DM healthcare team. A web-based survey was distributed to NM clinicians [Medical Doctors (MD), Doctors of Osteopathic Medicine (DO), Certified Nurse Practitioners (CNP), and Certified Physician Assistants (PA-C)] investigating barriers preventing referral of patients with T2DM to an RDN.

In total, 132 clinicians completed the survey (average age=52 years; 54.5% CNPs, 32.6% MDs, 9.1% PA-Cs, 3.9% DOs; 44% female). Most (67.4%) did not have an RDN employed in their practice. The majority …