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Articles 1 - 7 of 7
Full-Text Articles in Systems Neuroscience
The Serotonin 1b Receptor In Psilocybin’S Therapeutic-Like Mechanisms: From Behavior To Network Reorganization, Sixtine Fleury
The Serotonin 1b Receptor In Psilocybin’S Therapeutic-Like Mechanisms: From Behavior To Network Reorganization, Sixtine Fleury
Dartmouth College Ph.D Dissertations
Mood disorders represent a substantial and growing global health crisis, with ~10 million adults in the US meeting criteria for a major depressive disorder (MDD). Current first-line treatments such as SSRIs require long-term daily administration and fail a significant proportion of patients, driving renewed interest in rapid-acting alternatives. Psilocybin, a serotonergic psychedelic, shows growing clinical evidence of efficacy in treating depressive and anxiety disorders, often producing therapeutic effects persisting weeks to months following a single dose. Yet, the neural mechanisms underlying these enduring effects remain poorly understood and have been largely attributed to the serotonin 2A receptor (5-HT2AR) based on …
Identification And Delineation Of Neuronal Pathways Underlying Hypophagia, Jing Cai
Identification And Delineation Of Neuronal Pathways Underlying Hypophagia, Jing Cai
Dissertations and Theses (Open Access)
In terms of metabolism, eating disorders manifest in two extreme directions: overnutrition, which can lead to obesity, and malnutrition, which can result in underweight or even starvation. Both extremes compromise the quality of life. According to the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) standard, eating disorders affect up to 17.9% of young women and 2.4% of young men. Although eating disorders are primarily defined as mental disorders rather than metabolic disorders, they are intertwined with complex emotions and sensory perceptions. However, in contemporary animal research related to eating disorders and feeding behaviors, the majority of neuroscientists still examine …
Overexpression Of Corticotropin-Releasing Factor In The Nucleus Accumbens Enhances The Reinforcing Effects Of Nicotine In Female Versus Male Rats., Uribe, Victor Correa, Briana Pinales, Rodolfo Flores, Bryan Cruz, Zhiyin Shan, Adriaan Bruijnzeel, Arshad Khan, Laura O'Dell
Overexpression Of Corticotropin-Releasing Factor In The Nucleus Accumbens Enhances The Reinforcing Effects Of Nicotine In Female Versus Male Rats., Uribe, Victor Correa, Briana Pinales, Rodolfo Flores, Bryan Cruz, Zhiyin Shan, Adriaan Bruijnzeel, Arshad Khan, Laura O'Dell
Departmental Papers (Biology)
This study assessed the role of stress systems in the nucleus accumbens (NAc) in promoting sex differences in the reinforcing effects of nicotine. Intravenous self-administration (IVSA) of various doses of nicotine was compared following overexpression of corticotropin-releasing factor (CRF) in the NAc of female and male rats. Ovariectomized (OVX) females were also included to assess the role of ovarian hormones in promoting nicotine reinforcement. Rats received intra-NAc administration of an adeno-associated vector that overexpressed CRF (AAV2/5-CRF) or green fluorescent protein (AAV2/5-GFP). All rats were then given extended access (23 h/day) to an inactive and an active lever that delivered nicotine. …
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Lori Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Lori Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
Selected Works Temporary Series
No abstract provided.
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
Departmental Papers (Biology)
No abstract provided.
Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Arshad Khan, Alan Watts
Selected Works Temporary Series
No abstract provided.
Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts
Departmental Papers (Biology)
No abstract provided.