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Full-Text Articles in Systems Neuroscience
Individual Differences In Age And Testosterone Are Uniquely Associated With Neural Oscillatory Activity Serving Verbal Working Memory In Children And Adolescents, Abraham D. Killanin
Individual Differences In Age And Testosterone Are Uniquely Associated With Neural Oscillatory Activity Serving Verbal Working Memory In Children And Adolescents, Abraham D. Killanin
Theses & Dissertations
During the sensitive period of adolescence, the human brain undergoes dynamic changes in structure and function resulting in vast executive function gains. Verbal working memory (VWM) is one executive function that serves as a foundation to language acquisition, reading, and learning. Many have examined the development of VWM in youth, but few have probed age-related changes in the underlying neural oscillatory dynamics, and none have examined testosterone-related changes. We recorded magnetoencephalography during a modified Sternberg VWM task in 82 youth participants aged 6 – 14 years old and collected salivary testosterone samples. Significant oscillatory responses were identified and imaged using …
Aberrant Age-Related Alterations In Spontaneous Cortical Activity In Participants With Cerebral Palsy, Hannah Bergwell
Aberrant Age-Related Alterations In Spontaneous Cortical Activity In Participants With Cerebral Palsy, Hannah Bergwell
Theses & Dissertations
Cerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. These impairments appear to drastically worsen with advancing age within the CP population, although the underlying neuro-physiological mechanisms remain poorly understood. Herein, we began to address this knowledge gap by utilizing magnetoencephalographic (MEG) to study how aging impacts the amplitude of spontaneous brain activity (i.e., resting state) in a cohort of 38 individuals with spastic diplegic CP (Age = 22.08 ± 10.46 years) and 67 neurotypical controls (NT) (Age = 19.56 ± 10.25 years). Participants completed an eyes-closed resting-state paradigm while undergoing …
The Neurological Abnormalities Of The Brain And Spinal Cord In Individuals With Cerebral Palsy, Michael Trevarrow
The Neurological Abnormalities Of The Brain And Spinal Cord In Individuals With Cerebral Palsy, Michael Trevarrow
Theses & Dissertations
Cerebral palsy (CP) results from an insult to the developing brain, and it is one of the most common neurodevelopmental disorders in the United States. The insult produces a cascade of activity-dependent plastic changes within the neurophysiology and structure of the brain and spinal cord that ultimately leads to sensorimotor and mobility impairments that may increase in severity throughout the lifespan. Despite this phenomenon, there are a lack of neuroimaging studies in adults with CP, generating a knowledge gap in determining how brain and spinal cord activity and structure may be altered throughout the transition into adulthood. Furthermore, the specific …
Motor Control In Individuals With Multiple Sclerosis, David Arpin
Motor Control In Individuals With Multiple Sclerosis, David Arpin
Theses & Dissertations
This dissertation explored motor control in individuals with multiple sclerosis (MS) by quantifying the behavioral and neurophysiological deficits present in these individuals. We behaviorally quantified the precision of the ankle plantarflexor musculature of individuals with MS. Our results indicated that the individuals with MS had a greater amount of variability in the precision of the isometric ankle torques, and that this greater variability was related to decreased walking performance. To further explore whether these motor control deficits were due to aberrant cortical activity associated with planning motor actions, we used magnetoencephalography to assess the motor planning and execution stages of …