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Articles 1 - 4 of 4
Full-Text Articles in Systems Neuroscience
Design And Advancement Of Analytical Frameworks For In Vivo Single-Photon Calcium Imaging To Characterize Temporal- And Treatment-Dependent Neural Adaptations To Opioid Exposure And Withdrawal In The Medial Prefrontal Cortex, Alexia R. Alsum Dr.
Theses and Dissertations--Pharmacy
Despite the availability of several approved medications for opioid use disorder (OUD), it remains a significant public health concern characterized by persistent neurobiological adaptations that drive relapse and impede successful recovery. The medial prefrontal cortex (mPFC), a region critical for executive control and decision-making, undergoes pronounced functional changes during chronic opioid exposure and withdrawal, yet the cellular mechanisms underlying these adaptations remain poorly understood. This dissertation aims to investigate longitudinal alterations in mPFC neural activity across opioid exposure and withdrawal using in vivo single-photon calcium imaging and newly developed computational frameworks.
Following standard preprocessing to extract and normalize calcium traces, …
Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr
Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr
Graduate Theses, Dissertations, and Problem Reports (ETD)
Movement is a fundamental behavior that allows us to interact with the external world. Its importance to human health is most evident when it becomes impaired due to disease or injury. Physical and occupational rehabilitation remains the most common treatment for these types of disorders. Although therapeutic interventions may improve motor function, residual deficits are common for many pathologies, such as stroke. The development of novel therapeutics is dependent upon a better understanding of the underlying mechanisms that govern movement. Movement of the human body adheres to the principles of classic Newtonian mechanics. However, due to the inherent complexity of …
Neuroscholar’S Electronic Laboratory Notebook And Its Application To Neuroendocrinology, Arshad Khan, Joel Hahn, We-Cheng Cheng, Alan Watts, Gully Burns
Neuroscholar’S Electronic Laboratory Notebook And Its Application To Neuroendocrinology, Arshad Khan, Joel Hahn, We-Cheng Cheng, Alan Watts, Gully Burns
Selected Works Temporary Series
No abstract provided.
Neuroscholar’S Electronic Laboratory Notebook And Its Application To Neuroendocrinology, Khan, Joel Hahn, We-Cheng Cheng, Alan Watts, Gully Burns
Neuroscholar’S Electronic Laboratory Notebook And Its Application To Neuroendocrinology, Khan, Joel Hahn, We-Cheng Cheng, Alan Watts, Gully Burns
Departmental Papers (Biology)
No abstract provided.