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Articles 1 - 5 of 5
Full-Text Articles in Systems Neuroscience
Endogenous Light In The Brain: Investigating Sources, Propagation, And State-Dependent Emission, Emre Cicek
Endogenous Light In The Brain: Investigating Sources, Propagation, And State-Dependent Emission, Emre Cicek
Theses and Dissertations (Comprehensive)
Ultraweak photon emission (UPE), and by extension light, has long been thought to be a modality of communication in nature. Prior studies have already identified that UPE can depend on cell type and can be used to discern between malignant and benign cells. However, besides theoretical models, not much effort has been made to identify possible biological structures that would allow for light to be used as a method of communication in the human body. According to the framework set by Shannon’s Information Theory, for communication to be possible at minimum a transmitter, a transmission channel, and a receiver are …
Inductions Of Long-Term Potentiation With Biomimetic Electromagnetic Fields In Primary Neurons, Cooper E. Kansala
Inductions Of Long-Term Potentiation With Biomimetic Electromagnetic Fields In Primary Neurons, Cooper E. Kansala
Theses and Dissertations (Comprehensive)
Endogenous brain rhythms guide neural communication and plasticity, raising the question of whether weak, temporally structured electromagnetic fields (EMFs) that mimic these rhythms can modulate neuronal activity in a targeted, biomimetic manner. This thesis investigates whether patterned EMFs designed to reflect the temporal structure of hippocampal long-term potentiation (LTP) are more effective at inducing neural plasticity than conventional sinusoidal fields or no stimulation at all. Cortical neurons cultured from postnatal rats were exposed to patterned EMFs for 30 minutes and assessed across three distinct experimental domains. In Chapter 2, microelectrode array (MEA) recordings revealed that the LTP-patterned field significantly increased …
Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn
Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn
Theses and Dissertations (Comprehensive)
Downslope walking (DSW) has been proposed as a rehabilitation tool for people with Multiple Sclerosis (PwMS) although there are mixed findings in young adults (YA) regarding the balance control changes, despite both populations experiencing depressed spinal motor neuron (MN) pool excitability. Our aim was to determine whether YAs could demonstrate improved balance control in conjunction with SOL H reflex depression (estimate of spinal MN excitability) following DSW. We also aimed to determine whether reciprocal inhibition was a potential mechanism for H reflex depression via conditioned SOL H reflexes. Thirty young adults (23±1.4y, 6 males) were assigned to 30-minutes of DSW …
The Effects Of Manipulated Somatosensory Input On Simulated Falls During Walking, Sarah Mitchell-Ewart
The Effects Of Manipulated Somatosensory Input On Simulated Falls During Walking, Sarah Mitchell-Ewart
Theses and Dissertations (Comprehensive)
Previous research has demonstrated that there is a distinct relationship between aging and instability. The somatosensory system plays a significant role in balance control in conjunction with vision and the vestibular system (Qiu et al., 2012). Evidence has shown that manipulation of the mechanoreceptors on the plantar surface of the foot has a direct effect on balance control. By manipulating these receptors with hypothermic anesthesia and vibration, researchers are capable of simulating the effect of sensory modification on healthy individuals, in order to understand the role that plantar-surface sensation has in adapting to perturbation during gait (Perry et al., 2001; …
Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria
Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria
Theses and Dissertations (Comprehensive)
Movement disturbances in individuals with Parkinson’s disease (PD) have been associated with difficulties to plan complex actions. Performance of simple and complex actions overloads resources for individuals with Parkinson’s disease (PD). However, it is unclear if central resources required to plan gait adjustments while walking exacerbate gait disturbances of patients with PD. More specifically, it is unclear how gait impairments, sensory processing, and the dopaminergic system influence the load on processing resources (e.g. cognitive load) during the planning of step modifications. In order to investigate the relative influence of these factors on cognitive load and its impact on gait control, …