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Articles 1 - 3 of 3
Full-Text Articles in Systems Neuroscience
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez
Psychology ETDs
Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …
Hippocampal Functional Activity Following Prenatal Alcohol Exposure, Ryan E. Harvey
Hippocampal Functional Activity Following Prenatal Alcohol Exposure, Ryan E. Harvey
Psychology ETDs
Prenatal alcohol exposure (PAE) is among the most common developmental insults to the nervous system and is characterized by spatial memory disruption. There is a pressing need to identify physiological alterations that help explain this memory impairment. The hippocampal (HPC) formation and connected regions are a compelling candidate for this purpose as they are vital for navigation, spatial memory, and memory consolidation. This document is broken up into 3 main parts, a detailed review of the prior literature followed by several experiments. First, It starts out with a comprehensive review on spatial behavioral impairments following PAE and the synaptic & …
Moderate Prenatal Alcohol Exposure Impairs Performance In An Object-Place-Paired-Associate Task, Lilliana May Sanchez
Moderate Prenatal Alcohol Exposure Impairs Performance In An Object-Place-Paired-Associate Task, Lilliana May Sanchez
Psychology ETDs
Memory impairments, including spatial and object processing, are often observed in individuals with Fetal Alcohol Spectrum Disorder. Much attention has been directed towards the hippocampus, which displays significant alterations after moderate prenatal alcohol exposure (PAE). In the present study, we tested a moderate PAE rat model in an object-place-paired-associate (OPPA) task, previously shown to require hippocampal processing. The OPPA task was composed of training rats to discriminate between an identical pair of objects presented in 180° opposite arms of a radial arm maze. Animals were given a total of 10 trials per day over 14 consecutive days of training and …