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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 11 of 11
Full-Text Articles in Molecular and Cellular Neuroscience
Elucidating The Role Of The Α7 Nicotinic Receptor In The Etiology Of Schizophrenia., Michelle Johnson Chandley
Elucidating The Role Of The Α7 Nicotinic Receptor In The Etiology Of Schizophrenia., Michelle Johnson Chandley
Electronic Theses and Dissertations
The α7 subunit of the nicotinic receptor, a ligand gated ion channel with an affinity for nicotine, has long been implicated in the pathophysiology of schizophrenia due to the extremely high rate of smoking within the patient population. However, the exact role of the receptor has never fully been determined. In the following studies, various functions the receptor may assume in disease state are evaluated. There is a strong relationship between the immune system and schizophrenia, with the α7 subunit possibly serving as the link between the two. One of the following studies looks at the possibility of the receptor …
Amphetamine Sensitization And In Vivo Microdialysis Of The Nucleus Accumbens Core Of Adult Male And Female Rats D2-Primed As Neonates., Zackary Adam Cope
Amphetamine Sensitization And In Vivo Microdialysis Of The Nucleus Accumbens Core Of Adult Male And Female Rats D2-Primed As Neonates., Zackary Adam Cope
Electronic Theses and Dissertations
Neonatal administration of quinpirole produces significant increases in D2 receptor sensitivity that persists into adulthood. This phenomenon, known as D2 receptor priming, is consistent with pathology in schizophrenia. Rats were administered quinpirole or saline postnatally and raised to adulthood. In adulthood, rats were administered d-amphetamine sulfate or saline every other day and were placed in a locomotor arena where activity was measured over 7 trials. Results showed that D2-primed rats receiving amphetamine were higher in locomotor activity across all days of testing compared to other groups. This effect was more prominent in males than in females. …
Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro
Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro
Articles
BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients. FINDINGS: Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs …
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Cholinergic Neurons Regulate And Utilize Gdnf Secreted By C2c12 Skeletal Muscle Cells In Culture, John-Mary Vianney, John Spitsbergen
Cholinergic Neurons Regulate And Utilize Gdnf Secreted By C2c12 Skeletal Muscle Cells In Culture, John-Mary Vianney, John Spitsbergen
Biological Sciences Faculty and Graduate Student Research
Glialcell line-derived neurotrophicfactor (GDNF) has been regarded as a potent survival factor for a subpopulation of neurons. It has been shown that GDNF expression is upregulated in skeletal muscle of patients with early stage of neuromuscular diseases such as amyotrophic lateral sclerosis (ALS). Previous results from our laboratory showed that neural cells regulate GDNF secretion by skeletal muscle; non-innervated skeletal muscle appear to secrete more GDNF compared to innervated skeletal muscle. Two aims were examined in the current study. First, to examine whether neural cells inhibit GDNF through acetylcholine release. Second was to examine whether differentiated NG108-15 neural cells secrete …
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
The Endocytic Protein Numb Regulates App Metabolism And Notch Signaling: Implications For Alzheimer's Disease, George Kyriazis
The Endocytic Protein Numb Regulates App Metabolism And Notch Signaling: Implications For Alzheimer's Disease, George Kyriazis
Electronic Theses and Dissertations
Increased production of amyloid beta (A-beta) peptide, via altered proteolytic cleavage of amyloid protein precursor (APP), and abnormalities in neuronal calcium homeostasis play central roles in the pathogenesis of Alzheimer's disease (AD). Notch1, a membrane receptor that controls cell fate decisions during development of the nervous system, has been linked to AD because it is a substrate for the gamma-secretase protein complex in which mutations cause early-onset inherited AD. Numb is an evolutionarily conserved endocytic adapter involved in the internalization of transmembrane receptors. Mammals produce four Numb isoforms that differ in two functional domains, a phosphotyrosine-binding domain (PTB) and a …