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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Molecular and Cellular Neuroscience
Exposure Of Nervous System Cells To Polychlorinated Biphenyls (Pcbs) Results In Significant Alterations In Levels Of Expression Of Neurotrophic Factors, Charles F. Ide, Jay C. Means, Trisha M. Basford, John Spitsbergen
Exposure Of Nervous System Cells To Polychlorinated Biphenyls (Pcbs) Results In Significant Alterations In Levels Of Expression Of Neurotrophic Factors, Charles F. Ide, Jay C. Means, Trisha M. Basford, John Spitsbergen
Biological Sciences Faculty and Graduate Student Research
Toxic insult by PCBs results in learning and memory deficits in humans. Alterations in expression of neurotrophic factors and/or their receptors have been linked to changes in cognition. How PCBs affect cognition is not known. We propose that PCBs affect cognition by altering neurotrophic factor expression or effects. We exposed cultured C6 glial cells in medium containing PCB (Aroclor 1254 (10ppm)). Control cells were treated with DMSO or regular medium. Cells were incubated at 37o C for up to 72 hours. Medium samples were taken at 6hr, 24hr, 48hr, and 72hr intervals. Enzyme-linked immunosorbent assays (ELISA) were used to determine …
Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell
Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell
Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Cell Biology Of Apoe In Cortical Cultured Neurons: Possible Roles In Alzheimer's Disease, Anna G. Barsukova
Cell Biology Of Apoe In Cortical Cultured Neurons: Possible Roles In Alzheimer's Disease, Anna G. Barsukova
Masters Theses
The apolipoprotein E4 (apoE4) genotype is a major risk factor for Alzheimer's disease (AD). Previous studies have shown that apoE4 is less effective than apoE3 in supporting neurite outgrowth in adult mice cortical cultures. However the mechanism underlying this phenomenon is not known. To understand this mechanism and the broader role of apoE isoforms on neuronal biology I examined the rate of apoE isoforms internalization in neurons, effects of apoE isoforms on lipid uptake by neurons, effects of apoE isoforms on neuronal environment - microglia and on neuroregeneration, or neurogenesis.
I examined the binding and internalization of recombinant human apoE3 …