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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 7 of 7
Full-Text Articles in Molecular and Cellular Neuroscience
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Domain-Specific Olivocerebellar Projection Regulated By The Epha-Ephrin-A Interaction, Kazuhiko Nishida, John Flanagan, Masaru Nakamoto
Domain-Specific Olivocerebellar Projection Regulated By The Epha-Ephrin-A Interaction, Kazuhiko Nishida, John Flanagan, Masaru Nakamoto
Biology Faculty Publications
Neural maps in the vertebrate central nervous system often show discontinuously segregated, domain-to-domain patterns. However, the molecular mechanism that establishes such maps is not well understood. Here we show that in the chicken olivocerebellar system, EphA receptors and ephrin-As are expressed with distinct levels and combinations in mapping domains. When ephrin-A2 is retrovirally overexpressed in the cerebellum, the olivocerebellar map is disrupted, excluding axons with high receptor activity from ectopic expression domains. Conversely, overexpression of a truncated EphA3 receptor in the cerebellum reduces endogenous ligand activity to undetectable levels and causes aberrant mapping, with high receptor axons invading high ligand …
Effects Of Apolipoprotein E On Olfactory Nerve Plasticity In Mice, Jody L. Short
Effects Of Apolipoprotein E On Olfactory Nerve Plasticity In Mice, Jody L. Short
Masters Theses
No abstract provided.
Regional Specific Brain Apoe Modulation By The Estrous Cycle And Exogenous Estrogen, Emily Rosario
Regional Specific Brain Apoe Modulation By The Estrous Cycle And Exogenous Estrogen, Emily Rosario
Masters Theses
Previous studies have demonstrated that 17β-estradiol can modify apolipoprotein E (apoE) expression. I found that apoE protein varied as a function of the estrous cycle and 17β-estradiol (E2) in a region specific manner in the mouse brain. I also found that apoE concentration was lowest on estrus in the hippocampus, cingulate cortex and frontal cortex; apoE concentration was highest on estrus in the olfactory bulb and cerebellum. No changes in apoE were found in the striatum throughout the estrous cycle. Exogenous E2 significantly raised tissue levels in the olfactory bulb and cerebellum, but did not increase apoE in cortical samples …
Effects Of E2 On Apoe Secretion And Neurite Outgrowth In Cultured Adult Mouse Cortical Neurons, Fei Shen
Effects Of E2 On Apoe Secretion And Neurite Outgrowth In Cultured Adult Mouse Cortical Neurons, Fei Shen
Masters Theses
Estrogen replacement therapy appears to delay the onset of Alzheimer's disease (AD). The mechanism whereby estrogen prevents the pathogenesis of AD is unknown. In the present study, I examined the effects of 17-β-estradiol (E2) on neurite outgrowth from adult mice cortical neurons (AMC) in culture. I found that E2 increases apoE secretion and neurite outgrowth in AMC neurons from wild type mice in a dose dependent fashion. The neurite outgrowth promoting effect of E2 was not observed in AMC neurons derived from age-, sex-, and stain-matched apoE deficient/apoE gene knockout (apoE KO) mice. Furthermore, E2 has isoform specific effects on …
Modulation Of Apolipoprotein E Expression And Glial Activation In Mouse Olfactory Bulb During Estrous Cycle: An Immunohistochemical Study, Matthew Kircher
Modulation Of Apolipoprotein E Expression And Glial Activation In Mouse Olfactory Bulb During Estrous Cycle: An Immunohistochemical Study, Matthew Kircher
Masters Theses
Estrogen (E2) plasma levels fluctuate as a function of estrous cycling in the mouse. Apolipoprotein E (apoE) mRNA has been shown to increase in both hippocampal astrocytes and microglia during proestrus when plasma estrogen levels are high. The current study was designed to evaluate apoE localization and glial activation in mouse olfactory bulb (OB) as a function of the estrous cycle. In the rat OB, estrogen receptor β (ERβ) is present in the glomerular and external plexiform layers, but not the internal plexiform and granule cell layers. Normal female mice 2-3 months old at the start of the study were …