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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 9 of 9
Full-Text Articles in Molecular and Cellular Neuroscience
Administering A Mitophagy Inducing Compound (Mic) To Suppress Neuropathology In A Mouse Model Of Alzheimer’S Disease, Zachary Mayeri
Administering A Mitophagy Inducing Compound (Mic) To Suppress Neuropathology In A Mouse Model Of Alzheimer’S Disease, Zachary Mayeri
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Despite FDA-approved amyloid-beta (Aβ) therapies in Alzheimer’s disease (AD), Tau pathology remains untreated and is closely linked to cognitive decline. Mitophagy, the process of mitochondrial degradation, is vital for maintaining neuronal health, and its dysregulation is implicated in AD. Recently, our lab identified a mitophagy inducing compound (MIC) that extends the lifespan of C. elegans. We hypothesized that MIC would significantly mitigate neuropathology in an AD mouse model. In this study, aged 3x-Tg AD mice were fed an MIC-containing diet, and immunohistochemistry (IHC) was performed on hippocampal tissue to visualize Aβ and phospho-Tau (pTau) lesions. While MIC had little …
Evaluating The Brain-Enhancing Mitohormesis Of N-Propargylglycine, A Suicide Inhibitor Of Proline Dehydrogenase, To Offset The Proteotoxic Mechanisms Underlying Neurodegeneration In Huntington’S Disease And Evaluating The Phenotype Of A Mutant Pdia3 Knock-In Mouse Line As A Novel Genetic Model Of Neurological Disorders, Fadzai Teramayi
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Huntington’s Disease (HD) is characterized by atrophy of the striatal and cerebral cortical neurons producing a variety of severe, and life-shortening neurologic symptoms including motor dysfunction, cognitive decline, psychiatric disturbances, and weight loss. As with other life-threatening neurodegenerative disorders, HD has no effective treatment capable of preventing or mitigating its underlying hallmark, subcellular and pathogenetic mechanism, that is, proteotoxicity. While it has been suggested that inducing brain mitohormesis might offer a promising therapeutic strategy, to date, no brain-penetrating mitohormesis-inducing agent has yet been identified or tested in any neurodegenerative disease mouse model. Recently, N-propargylglycine (N-PPG) was shown …
Exploring The Relationship Between Cellular Senescence, Apolipoprotein E, And Alzheimer’S Disease, Buay Deng
Exploring The Relationship Between Cellular Senescence, Apolipoprotein E, And Alzheimer’S Disease, Buay Deng
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Alzheimer’s disease (AD) is the most common form of dementia in the world and currently affects more than 50 million people and has no cure to date. One of its major neuropathological hallmarks is the presence of senile plaques—formed from Amyloid-β (Aβ) oligomers. Aβ has also been associated with the development of cellular senescence in preclinical AD models, suggesting that cellular senescence may be mechanistically involved in disease progression. Cellular senescence is a stress response that occurs when cells are exposed to degenerative factors that puts them into permanent cell cycle arrest, this process increases with age. Apolipoprotein E (ApoE) …
Mechanisms Of How Diet And Light Interact To Influence Drosophila Longevity Through The Eye, Charles H. Lau
Mechanisms Of How Diet And Light Interact To Influence Drosophila Longevity Through The Eye, Charles H. Lau
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Previous studies in Drosophila melanogaster have established that overexposure to light damages photoreceptors and that photoreceptor degeneration contributes to shortened lifespans. However, the role of diet and circadian rhythms in the eye has not yet been elucidated. Many vital processes in the eye are regulated by circadian rhythms, and circadian misalignment has been proven as a driver of aging. In the eye, one of the most enriched circadian functions is phototransduction. Phototransduction plays a major role in the organism’s ability to detect light. Our lab has previously proven that Dietary Restrictions (DR) can play a role in amplifying circadian rhythms …
Determining The Role Of Methylglyoxal (Mgo) And The Trpa1 Channel In Inducing Astrocyte Senescence And Neurodegeneration, Natalie Hill
Determining The Role Of Methylglyoxal (Mgo) And The Trpa1 Channel In Inducing Astrocyte Senescence And Neurodegeneration, Natalie Hill
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Aging is the largest risk factor for the development of Alzheimer’s disease (AD) and related dementias. A recently proposed driver of age-related pathologies is cellular senescence, a phenotype that consists of cell-cycle arrest and an inflammatory response known as the senescence-associated secretory phenotype (SASP). Although there is a link between the accumulation of senescent cells and neurodegeneration, much remains unknown about how senescent cells arise in the brain. Astrocytes are the most abundant cell type in the brain that serve important roles like supporting neurons and proliferating in response to stress. Methylglyoxal (MGO) is a glycolytic byproduct that can react …
Modulating Matrix Metalloproteases And Inflammation In Huntington’S Disease, Alejandro Lopez Ramirez
Modulating Matrix Metalloproteases And Inflammation In Huntington’S Disease, Alejandro Lopez Ramirez
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Huntington’s disease (HD) is a rare and incurable autosomal neurodegenerative disease affecting 1-10 in every 100,000 people in the world. There is no cure for HD and treatments available alleviate certain symptoms for short periods of time. Evidence suggests that neuropathology of HD begins with the proteolysis of the mutated Huntingtin (mHTT) protein. A variety of proteases, like the matrix metalloproteases, cleave mHTT creating proteinaceous fragments that are thought to be neurotoxic. As these fragments increase in the brain, the damage to neurons also increases, leading to chronic inflammation due to hyper reactive microglia and astrocytes attempting to minimize and …
Investigating Neuroinflammation And Demyelination In The Nervous System Of Twitcher Mice By The Use Of Immunohistochemistry, Irene Wilson
Investigating Neuroinflammation And Demyelination In The Nervous System Of Twitcher Mice By The Use Of Immunohistochemistry, Irene Wilson
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Neuroinflammation and demyelination are the hallmark lesions of the Twitcher mouse—the model of Krabbe Disease. By analyzing hemibrains and sciatic nerves via immunohistochemistry, we supported the microglial hypothesis that early activation of microglial cells, macrophages, and globoid cells in the nervous system of Twitcher mice results in specific cellular polarization states that may contribute to myelin loss. The influx of activated macrophages seen in both the central and peripheral nervous systems at days 21 and 17, respectively, accounted for this polarization. Using selected M1 and M2 markers, YKL-40, and GPNMB and CD206, respectively, we proved that microglial cells and macrophages …
Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad
Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad
Dissertations, Masters Theses, Capstones, and Culminating Projects
An emerging technology known as three-dimensional (3D) tissue engineering has allowed scientists to mimic tissues found in vivo. Previous studies indicate that it is possible to differentiate dissociated mouse embryonic stem cells (mESCs) into 3D retinal tissues in vitro (Bertacchi, 2015; Eiraku, 2012). The newly differentiated retinal tissues are said to encompass all of the major components found in retinal tissues. The generation of in vitro 3D tissues holds great potential in terms of patient-specific disease modeling. Although various diseases have been well-studied in animal models, there are limitations with regards to patient-specificity. The generation of animal models to study …
Synaptic Homeostasis At The Drosophila Neuromuscular Junction: Molecular Mechanisms And Developmental Adaptation, Lindsay A. Gray
Synaptic Homeostasis At The Drosophila Neuromuscular Junction: Molecular Mechanisms And Developmental Adaptation, Lindsay A. Gray
Dissertations, Masters Theses, Capstones, and Culminating Projects
No abstract available