Cognitive Neuroscience Commons^™

Anterior Cingulate Cortex Connectivity And The Role In Neuroticism: A Diffusion-Weighted-Imaging-Based Investigation Of Limbic And Prefrontal Circuits., Jake Cox Ii

College of Arts & Sciences Senior Theses

Neuroticism is a trait which has been shown to significantly predict psychopathology. Investigating its neurobiological underpinnings may uncover a brain-based relationship that allows clinicians to conceptualize a shared predispositional factor across multiple psychopathologies, implicating treatment protocols. Inter-connectivity network and structural variation has been shown to be implicated in neuroticism, more specifically the frontoparietal network, default mode network, salience networks, and limbic networks. These networks tackle executive, salience, and emotional information, respectively. The anterior cingulate cortex (ACC) is a brain region nested between and functionally related to various networks stated above that are implicated in neuroticism. As such, it was hypothesized …

Emotional Content In Working Memory Processes: An Fmri Study., Manal Zafar

Electronic Theses and Dissertations

Working memory (WM) is a dynamic system that processes and manipulates both goal-relevant and goal-irrelevant information, integral to higher-level cognition and executive control (Fujii, 2001; Nyberg & Erikkson, 2016). The processing and manipulation of representations is modulated by the affective nature of the information (Pessoa, 2009) such that negative information can either impair or enhance WM processing. WM impairments are seen commonly across clinical disorders such as depression, anxiety, PTSD and schizophrenia (Levens & Gotlib, 2010; Joorman et a., 2011; Brodziak et al., 2015). Specifically, negative information is known to have differential processing in WM compared to neutral and positive …

Exploring Resilience With Neuroimaging: Moderators Of The Impacts Of Childhood Traumatic Stress On Fear Processing., Karisa June Hunt

Electronic Theses and Dissertations

Childhood trauma is an alarming public health crisis, and the field of trauma research is relatively underdeveloped given population rates of childhood trauma and post-trauma pathology. Even less studied than the impacts of trauma are the impacts of resilience, and the protective factors that foster it. It is widely acknowledged that an investigation of trauma is incomplete without an investigation of its impacts on fear processing. Understanding the neural underpinnings of resilience to childhood trauma during fear conditioning is vital to the development of therapeutic interventions able to moderate its devastating impacts. The present study investigated the complex neurobiological interplay …

Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman

Undergraduate Research Posters

Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …

The Neural Sequalae Of Subjectively Experiencing Autobiographical Memories From The Remote Past And Recent Present Using Fmri, Ava G. Peruski, Nim Singh, Brendan E. Depue

The Cardinal Edge

Autobiographical memory is central to one's sense of self and continuity from past to present. Despite this, there is little research on the neural correlates underlying individual subjective experience of autobiographical memory and how that is related to brain phenomena (i.e., activity, communication). The purpose of this study was to help minimize this gap. We recruited twenty healthy adult participants, who were asked to generate memory cues (1-3 word descriptions) for locations and objects from their early and recent life. After 24 hours, participants were shown these cues then asked to recall the appropriate memory while in an fMRI scanner. …

Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. It is one of the leading sources of morbidity and mortality in the aging population AD cardinal symptoms include memory and executive function impairment that profoundly alters a patient’s ability to perform activities of daily living. People with mild cognitive impairment (MCI) exhibit many of the early clinical symptoms of patients with AD and have a high chance of converting to AD in their lifetime. Diagnostic criteria rely on clinical assessment and brain magnetic resonance imaging (MRI). Many groups are working to help automate this process to improve the clinical workflow. Current …

Extended Functional Connectivity Of Convergent Structural Alterations Among Individuals With Ptsd: A Neuroimaging Meta-Analysis, Brianna S. Pankey, Michael C. Riedel, Isis Cowan, Jessica E. Bartley, Rosario Pintos Lobo, Lauren D. Hill-Bowen, Taylor Sato, Erica D. Musser, Matthew T. Sutherland, Angela R. Laird

Psychology Faculty Publications

Background: Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore, how structural alterations may be associated with brain function, as measured by task-free and task-based functional connectivity, remains to be elucidated.

Methods: Using emergent meta-analytic techniques, we sought to first identify a consensus of structural alterations in PTSD using the anatomical likelihood estimation (ALE) approach. Next, we generated functional …

Developing Methods To Detect And Diagnose Chronic Traumatic Encephalopathy During Life: Rationale, Design, And Methodology For The Diagnose Cte Research Project, Jeffrey Cummings, Numerous Authors, See Full List Below

School of Medicine Faculty Research

Background: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the “Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project.” The objectives of this multicenter project are to: develop in vivo fluid and neuroimaging biomarkers for CTE; characterize its clinical presentation; refine …

Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell

All NMU Master's Theses

Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …

Diversifying Participation: The Rarity Of Reporting Racial Demographics In Neuroimaging Research, Madeline Goldfarb

Pitzer Senior Theses

Background: Functional neuroimaging techniques have been instrumental to progress in the cognitive and behavioral sciences; however, their increasing prevalence has evoked conversations concerning limitations associated with reproducibility and bias (Gilmore et al., 2017). While the literature has explored several mechanisms driving issues of replicability, few discussions have considered the effects of confounding social and environmental variables such as age, sex, socioeconomic status, and race (Sauce & Matzel, 2013). The prevailing racial, cultural, and socioeconomic bias in scientific research and the methodological limitations of EEG perpetuate racial and ethnic homogeneity in participation, eliciting qualms regarding the generalizability of findings (Henrich et …

The Generalization Of Fear Condition Between Viewed And Imagined Percepts, Lauryn Michelle Burleigh

LSU Master's Theses

Mental images can provoke intense emotional states (Holmes & Matthews, 2010). Imagery and perception have common neural and physiological mechanisms, including activation of the early visual areas (Albers et al., 2013). We tested the prediction that individuals can acquire fear to imagined percepts and if this fear transfers to viewing percepts, using fMRI and self-reported measures to determine participants’ fear. The participants completed a task in which they viewed and imagined two stimuli, and were fear conditioned when imagining the CS+. Participants are only told that mild electrical stimulation will be paired with one of the stimuli, but not which …

Neural Correlates Of Polysubstance Use: Differential And Interactive Effects Of Alcohol And Cannabis On The Adolescent Brain, Joseph Aloi

Theses & Dissertations

Two of the most commonly used and abused substances by adolescents in the United States are alcohol and cannabis, which are associated with adverse medical and psychiatric outcomes. Alcohol use and cannabis use during adolescence is also associated with an increased risk of alcohol use disorder (AUD) and/or cannabis use disorder (CUD) in adulthood as well as increased likelihood of relapse after successful treatment. Despite this, much of the previous work on the neurobiology of substance use disorders has focused on adult substance use. This work has shown that individuals with AUD and/or CUD show dysfunction within reward processing, emotion …

What Would We Like To Know By Imaging The Brains Of Dogs?, Ralph Adolphs

Animal Sentience

Using fMRI to study emotions in animals is important, fascinating, and fraught with methodological and conceptual problems. Cook et al. are doing it, and there is no question that they and others will be doing it better and better as time goes on. Where will this lead us? What could fMRI in principle tell us about the minds of nonhuman animals?

Can Neuroimaging In Dogs Have Practical Implications?, Tiffani J. Howell

Animal Sentience

Jealousy, or at least aggression, can be observed in dogs using neuroimaging techniques, but this response attenuates quickly following repeated exposure to the aggression-inducing stimulus. This may have a practical application. Early socialisation as a puppy, and habituation as an adult dog, could help prevent undesirable behaviours such as predatory behaviour. It is unclear whether these processes are the same, and affected only by the dog’s age. Neuroimaging could help us understand whether the same neurological processes underlie socialisation and habituation, and whether self-rewarding behaviours such as predatory behaviour could be stopped using socialisation/habituation techniques.

Unconscious Processing Of Unattended Features In Human Visual Cortex, Tatiana Aloi Emmanouil, Philip Burton, Tony Ro

Publications and Research

Unconscious processing has been convincingly demonstrated for task-relevant feature dimensions. However, it is possible that the visual system is capable of more complex unconscious operations, extracting visual features even when they are unattended and task irrelevant. In the current study, we addressed this question by measuring unconscious priming using a task in which human participants attended to a target object's shape while ignoring its color. We measured both behavioral priming effects and priming-related fMRI activations from primes that were unconsciously presented using metacontrast masking. The results showed faster RTs and decreases in fMRI activation only when the primes were identical …

Pain As Fact And Heuristic: How Pain Neuroimaging Illuminates Moral Dimensions Of Law, Amanda C. Pustilnik

Faculty Scholarship

Legal statuses, prohibitions, and protections often turn on the presence and degree of physical pain. In legal domains ranging from tort to torture, pain and its degree do important definitional work by delimiting boundaries of lawfulness and of entitlements. The omnipresence of pain in law suggests that the law embodies an intuition about the ontological primacy of pain. Yet, for all the work done by pain as a term in legal texts and practice, it has had a confounding lack of external verifiability. As with other subjective states, we have been able to impute pain’s presence but have not been …

Orbitofrontal Cortex Provides Cross-Modal Valuation Of Self-Generated Stimuli, William A. Cunningham, Ingrid J. Haas, Ashley S. Waggoner

Department of Political Science: Faculty Publications

Prior research has shown that the orbitofrontal cortex (OFC) plays an important role in the representation of the evaluation of stimuli, regardless of stimulus modality. Based on these findings, researchers have proposed that the OFC serves a common currency function, allowing for the direct comparison of different types of perceptual stimuli (e.g. food, drink, money). The present study was designed to extend this research and investigate whether these same regions of OFC that have been identified in previous research are involved in evaluating imagined stimuli. Specifically, we asked participants to draw on prior attitudinal knowledge to generate internal representations of …

Neuroimaging And Capital Punishment, O. Carter Snead

Journal Articles

Can brain scans be used to determine whether a person is inclined toward criminality or violent behavior?

This question, asked by Senator Joseph Biden of Delaware at the hearing considering the nomination of John Roberts to be Chief Justice of the United States, illustrates the extent to which cognitive neuroscience - increasingly augmented by the growing powers of neuroimaging, the use of various technologies to directly or indirectly observe the structure and function of the brain - has captured the imagination of those who make, enforce, interpret, and study the law.

The attraction of the legal community to cognitive neuroscience …

Neuroimaging, Entrapment, And The Predisposition To Crime, O. Carter Snead

Journal Articles

Professor Tovino's (2007) paper is a welcome contribution to the emerging body of scholarship on the issues arising at the nexus of cognitive neuroscience (and neuroimaging in particular) and the law. It is a useful overview of the various ways in which neuroimaging might affect a wide array of legal questions. Though many of the issues that Tovino discusses are at present quite speculative (as she acknowledges), it is always wise to take advantage of the rare opportunity to reflect on the legal, ethical, and public policy implications of developments in biotechnology before they are upon us. In that spirit, …