Behavioral Neurobiology Commons^™

Psychological Manipulation And Cluster-B Personality Traits Of Cult Leaders, Jennifer Henderson

Walden Dissertations and Doctoral Studies

Cults, thousands of which exist in the United States, present a societal problem due to their ability to rob followers of free will, sever familial ties, and even incite violence, such as the case of the Manson Family. Their leaders' manipulation of followers can be dangerous, resulting in emotional and physical abuse. There is a lack of meaningful literature on how personality traits may affect cult leaders’ abilities to recruit and maintain members. The purpose of this study was to examine how Cluster-B personality traits (narcissism, borderline, antisocial, and histrionic) relate to cult leaders’ abilities to manipulate. The qualitative case …

Perceived Factors Of Intimate Partner Violence On Women Diagnosed With Post-Traumatic Stress Disorder, Angela M. Halcovich

Walden Dissertations and Doctoral Studies

Post-Traumatic Stress Disorder (PTSD) is a prevalent diagnosis, and many human and social services professionals strive to understand its components, to ensure that they serve the population properly. However, little is known about how PTSD may influence women’s vulnerabilities to and future experiences of intimate partner violence (IPV). Emphasizing relationship coaching, which provides tools to foster healthy relationships, within the therapeutic curricula on rehabilitation for women with PTSD may result in reduced chances to experience IPV as women integrate back into their everyday life after being diagnosed and treated for PTSD. The purpose of this generic qualitative study was to …

Mediators Between Job Stress And Health Quality Of Life Among Adults With Irritable Bowel Syndrome, Aida M. Benitez-Rexach

Walden Dissertations and Doctoral Studies

Irritable bowel syndrome (IBS) is a functional gastrointestinal affliction that affects millions around the globe, impacting health-related quality of life (HRQoL). The biopsychosocial model, Folkman and Lazarus’ transactional model of stress, Leventhal’s common sense model of self-regulation health and illness, and Bronfenbrenner’s human ecology theory are relevant to conceptualize interactions among environmental factors, biopsychosocial responses, and health-related quality of life (HRQoL). This quantitative, cross-sectional, complex correlational study sought to provide more understanding of how and whether IBS symptoms of pain, cognitive functioning, and interpersonal functioning serve as mediators between work stress and HRQoL. A total of 133 English-speaking volunteers from …

Selective Gsk3b Overexpression In Medial Prefrontal Cortex Camkiia Cells Produces Sex-Specific Changes In Ethanol Self-Administration, Anxiety-Like Behavior, And Working Memory, Sam Gottlieb, Zachary Tatom, Michael F. Miles

Graduate Research Posters

Background: Glycogen synthase kinase 3 beta (Gsk3b) is central in a gene network regulated by ethanol in mouse medial prefrontal cortex (mPFC). GSK3B abundance/activity modulations regulate ethanol consumption, suggesting GSK3B could be a target in treating alcohol use disorder. However, the critical cell type in this ethanol response is not yet known, nor have sex differences in GSK3B modulations been fully investigated. Here we report results of GSK3B overexpression selectively in CamKIIa⁺ mPFC cells on multiple behaviors.

Methods: Mice underwent stereotaxic injections to overexpress GSK3B in mPFC CamKIIa⁺ cells or control virus (n=4-6/sex/virus). We assayed working …

Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott

Graduate Theses, Dissertations, and Problem Reports (ETD)

For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …

Perceived Factors Of Intimate Partner Violence On Women Diagnosed With Post-Traumatic Stress Disorder, Angela M. Halcovich

Walden Dissertations and Doctoral Studies

Post-Traumatic Stress Disorder (PTSD) is a prevalent diagnosis, and many human and social services professionals strive to understand its components, to ensure that they serve the population properly. However, little is known about how PTSD may influence women’s vulnerabilities to and future experiences of intimate partner violence (IPV). Emphasizing relationship coaching, which provides tools to foster healthy relationships, within the therapeutic curricula on rehabilitation for women with PTSD may result in reduced chances to experience IPV as women integrate back into their everyday life after being diagnosed and treated for PTSD. The purpose of this generic qualitative study was to …

Neural Systems Underlying Rdoc Social Constructs: An Activation Likelihood Estimation Meta-Analysis, Rosario Pintos Lobo, Katherine L. Bottenhorn, Michael C. Riedel, Afra I. Toma, Megan M. Hare, Donisha D. Smith, Alexandra C. Moor, Isis K. Cowan, Javier A. Valdes, Jessica E. Bartley, Taylor Salo, Emily R. Boeving, Brianna Pankey, Matthew T. Sutherland, Erica D. Musser, Angela R. Laird

Psychology Faculty Publications

Neuroscientists have sought to identify the underlying neural systems supporting social processing that allow interaction and communication, forming social relationships, and navigating the social world. Through the use of NIMH’s Research Domain Criteria (RDoC) framework, we evaluated consensus among studies that examined brain activity during social tasks to elucidate regions comprising the “social brain”. We examined convergence across tasks corresponding to the four RDoC social constructs, including Affiliation and Attachment, Social Communication, Perception and Understanding of Self, and Perception and Understanding of Others. We performed a series of coordinate-based meta-analyses using the activation likelihood estimate (ALE) method. Meta-analysis was performed …

Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation, Samantha Malone

Theses and Dissertations--Psychology

Evidence suggests that rats given long access (LgA) sessions to self-administer (SA) opioids escalate their intake, while also showing greater withdrawal severity and drug-induced reinstatement compared to rats maintained on short access (ShA) daily SA sessions. Little is known about the neural changes that occur during opioid escalation that may impact withdrawal and relapse. Past work examining opioid SA using ShA sessions in rodents has identified the central amygdala (CeA) as an area of interest that becomes hyperactive in acute withdrawal and may be involved in the incubation of craving that occurs after protracted withdrawal. However, these studies have not …

Vapourized Cannabis Extract Administration Impairs Memory And Alters Neural Activity In Laboratory Rats, Megan Chladny

Theses and Dissertations (Comprehensive)

Although people have smoked cannabis for millennia, administration of cannabis by heating the dried plant material or distilled extracts to a temperature just below the combustion point (i.e., vapourization or "vaping") has rapidly increased over the past few years (Javadi-Payder, Cole, and Taffe, 2018; Manwell, Charchoglyan, Brewer, Matthews, Heipel, and Mallet, 2014). Conversely, most of the cannabinoid research using rodent models has used parenteral routes of administration to examine the effects of purified cannabis extracts such as ∆⁹-tetrahydrocannabinol (THC), making it difficult to directly compare laboratory research to human drug use. Building on previous studies showing that THC …

Investigation Of Regulator Of G Protein Signaling-12 (Rgs12) As A Modulator Of Monoamine Transporters And Behavioral Responses To Cocaine, Allison Noel White

Graduate Theses, Dissertations, and Problem Reports (ETD)

Stimulant use disorder is a psychiatric illness that is characterized by repeated use of stimulant drugs despite harm to the user. There are currently no Federal Drug Administration (FDA)- approved medications for stimulant use disorder, and the number of stimulant use-associated deaths have increased over the past decade. Given the prevalence of and lack of treatments for stimulant use disorder, there is an urgent need to identify new drug targets and treatments for this illness. Our group is investigating Regulator of G protein Signaling-12 (RGS12) as one such potential drug target for stimulant use disorder. Mice lacking RGS12 are insensitive …

Artificial Light At Night Disrupts Pain Behavior And Cerebrovascular Structure In Mice, Jacob Raymond Bumgarner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Artificial Light at Night Disrupts Pain Behavior and Cerebrovascular Structure in Mice

Jacob R. Bumgarner

Circadian rhythms are intrinsic biological processes that fluctuate in function with a period of approximately 24 hours. These rhythms are precisely synchronized to the 24- hour day of the Earth by external rhythmic signaling cues. Solar light-dark cycles are the most potent environmental signaling cue for terrestrial organisms to align internal rhythms with the external day. Proper alignment and synchrony of internal circadian rhythms with external environmental rhythms are essential for health and optimal biological function.

The modern human environment on Earth is no longer …

Sense And Sensitivity: Spatial Structure Of Conspecific Signals During Social Interaction, Keshav Ramachandra

Graduate Theses, Dissertations, and Problem Reports (ETD)

Organisms rely on sensory systems to gather information about their environment. Localizing the source of a signal is key in guiding the behavior of the animal successfully. Localization mechanisms must cope with the challenges of representing the spatial information of weak, noisy signals. In this dissertation, I investigate the spatial dynamics of natural stimuli and explore how the electrosensory system of weakly electric fish encodes these realistic spatial signals. To do so In Chapter 2, I develop a model that examines the strength of the signal as it reaches the sensory array and simulates the responses of the receptors. The …

Cue Reactivity In Electronic Cigarette Users With Sign-Tracking Or Goal-Tracking Behaviors, Polina Krom

Graduate Theses, Dissertations, and Problem Reports (ETD)

Polina Krom

Cue reactivity is an important predictor of addiction course and relapse. However, cue reactivity is only observed after an addiction develops. As such, it is unclear to what degree cue reactivity represents a state stemming from the addiction process versus a trait-like propensity towards developing cue-reward associations. Work in animal models has pointed to important individual differences in trait-like inclination to attribute incentive salience to reward-predictive cues that is associated with addiction-relevant behavioral and neurobiological features. These individual differences manifest as sign-tracking (ST) and goal-tracking (GT) behaviors during Pavlovian conditioning. Little research has attempted to translate ST and …