Neuroscience and Neurobiology Commons^™

Time-Dependent Changes In Cocaine-Seeking Behavior And Extracellular Dopamine Levels In The Amygdala During Cocaine Withdrawal, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Time-Dependent Changes In Cocaine-Seeking Behavior And Extracellular Dopamine Levels In The Amygdala During Cocaine Withdrawal, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Effects Of Sch-23390 On Dopamine D1 Receptor Occupancy And Locomotion Produced By Intraaccumbens Cocaine Infusion, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Immunolesions Using Site Specific Injections Of 192-Lgg Saporin Into The Basal Forebrain Fail To Affect Radial Arm Maze Performance In The Male Rat, Lesley J. Hickman '96

Honors Projects

In this study I investigated the effects of 192-lgG saporin injections into the medial septal area.(MSA) and nucleus basalis magnocel/ularis (NBM) on radial arm maze performance in the male rat. The results of the present study reveal that combined injections of 192-lgG saporin into the basal forebrain failed to disrupt RAM performance when compared to vehicle-injected controls. In addition, intraperitoneal injections using a muscarinic receptor blocker, scopolamine, failed to reveal a compensatory response of the cholinergic basal forebrain that may have explained the lack of behavioral effects of 192IgG saporin. Consequently, the results of this study suggest that a selective …

Dose-Dependent Characterization Of The Rewarding And Stimulant Properties Of Cocaine Across Intraperitoneal And Intravenous Routes Of Administration, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Differential Effects Of Intra-Accumbens Sulpiride On Cocaine-Induced Locomotion And Conditioned Place Preference, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Dopamine Overflow In The Nucleus Accumbens During Extinction And Reinstatement Of Cocaine Self-Administration Behavior, Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Differential Effects Of Intra-Accumbens Sulpiride On Cocaine-Induced Locomotion And Conditioned Place Preference, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Dopamine Overflow In The Nucleus Accumbens During Extinction And Reinstatement Of Cocaine Self-Administration Behavior, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Dose-Dependent Characterization Of The Rewarding And Stimulant Properties Of Cocaine Across Intraperitoneal And Intravenous Routes Of Administration, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Localization Of Dopamine Receptor Subtypes Occupied By Intra-Accumbens Administration Of Selective Antagonists That Reverse Cocaine-Induced Locomotion., Laura O'Dell

Selected Works Temporary Series

No abstract provided.

Localization Of Dopamine Receptor Subtypes Occupied By Intra-Accumbens Administration Of Selective Antagonists That Reverse Cocaine-Induced Locomotion., Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

Comparison Of The Effects Of Saporin-Igg Injections Into The Nucleus Basalis Magnocellularis And Medial Septal Area Of Male Rat As Assessed By The Morris Water Maze Task, Alexander R. V. Mccampbell '95

Honors Projects

Alzheimer's disease currently afflicts approximately 4 million people in the United States, with 100,000 new cases being reported each year. As post mortem examination of AD patientsI brains has revealed a significant decrease in the number of cholinergic neurons, one approach we have taken is to look at the correlation between the depletion of certain cholinergic markers in animals and the resulting behavioral deficits. Two regions of specific interest are the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM). These regions are important because they are the major source of cholinergic neurons in the brain, they are selectively …

Toward An Understanding Of Alzheimer's Disease: The Effects Of B-Amyloid(1-42) And Ibotenic Acid On The Retention Of A Spatial Learning Task In Rats F:Ollowing Multiple Injections Into The Hippocampus, Jason Pequette '94

Honors Projects

Neuropathologically, Alzheimer's disease (AD) is characterized by neuritic plaques and neurofibrillary tangles. Evidence has suggested that a protein called B-amyloid (BA) is a major component of the neuritic plaques and may playa role in the neurodegeneration seen in AD. The cellular mechanisms by which BA induces neurotoxicity, however, are still unclear. Recent evidence suggests that the aggregational state of BA may be relevant to its neurotoxicity. Whether portions of the BA protein or the entire sequence produces neurotoxicity in neurons, however, remains a controversy. Still another controversy is whether BA is directly neurotoxic to neurons or whether it increases the …

Effect Of Unilateral Temporal-Lobe Excision On Perception And Imagery Of Songs, Robert J. Zatorre, Andrea R. Halpern

Faculty Journal Articles

Auditory imagery for songs was studied in two groups of patients with left or right temporal-lobe excision for control of epilepsy, and a group of matched normal control subjects. Two tasks were used. In the perceptual task, subjects saw the text of a familiar song and simultaneously heard it sung. On each trial they judged if the second of two capitalized lyrics was higher or lower in pitch than the first. The imagery task was identical in all respects except that no song was presented, so that subjects had to generate an auditory image of the song. The results indicated …

The Energetic Costs Of Rough And Tumble Play In The Juvenile Rat, Stephen M. Siviy, Dale M. Atrens

Psychology Faculty Publications

The metabolic costs of rough-and-tumble play behavior were studied in juvenile rats. Using indirect calorimetry, it was determined that energy expenditure during play is increased by 66-104% over the resting metabolic rate, indicating that play accounts for between 2% and 3% of the total daily energy budget of the rat. In a subsequent experiment, food intake and body weight were monitored for three weeks in rats allowed to play for one hour per day and in rats not allowed to play. While the body weights of the two groups did not differ significantly from each other, those rats allowed to …

Effects Of Age On Motor Preparation And Restructuring, Paul Amrhein, Noreen Goggin, George Stelmach

Department of Psychology Faculty Scholarship and Creative Works

Age-related decrements in motor plan restructuring were investigated. In this experiment, older and younger adults performed a discrete aiming task that involved responses that were precued and responses that were modified at the time of an imperative signal. On 75% of the trials, the precue specified the response-stimulus (valid trials) with respect to the movement parameters of the arm (left or right) and direction (toward or away). On the remaining 25% of the trials, the response-stimulus was different from the precue (invalid trials) in that the subject was required to modify a planned movement by changing the arm to be …

Similarities Between Human And Animal Spatial Memory: Item And Order Information, Robert H.I. Dale

Scholarship and Professional Work - LAS

Human subjects, sitting at the center of a circle of eight lights, were tested on analogues of radial-maze item-recognition (Roberts & Smythe, 1979) and order-recognition (Kesner & Novak, 1982) tasks. Subjects in the item-recognition condition saw a list of seven lights, and then the nonlist (eighth) light was tested against the first, fourth, or seventh light from the list. The sub- jects were required to point toward the non list light. Subjects in the order-recognition condition saw a series of eight lights, followed by a test of the first and second, fourth and fifth, or seventh and eighth serial positions. …

Task Load, Stimulus Encodability, Test Latency, And Processing Efficiency Effects On The Visual Recognition Memory Of The Chronic Neuropsychologically Impaired, Thomas W. C. Blash

All-Inclusive List of Electronic Theses and Dissertations

Psychologists assessing the visual recognition memory (VRM) of neuropsychologically compromised clients with the dual diagnosis of cognitive impairment and emotional sequelae confront two problems, including the dearth of studies dealing with the dually diagnosed (Menolascino, 1984) and inconsistent findings from past research on the effects of cerebral compromise on visual memory (Boller & DeRenzi, 1967; Cremonini, DeRenzi, & Faglioni, 1980; DeRenzi & Spinnler, 1966; DeRenzi, Faglioni, & Villa, 1977; Gouvier, 1983; Kimura, 1963). This study examines the effects of task load (number of stimuli), stimulus encodability, test latency, and cognitive processing efficiency on a group of dually diagnosed individuals who …

Sensory Modulation Of Juvenile Play In Rats, Stephen M. Siviy, Jaak Panksepp

Psychology Faculty Publications

A series of experiments was conducted to determine the extent to which somatosensory stimulation is necessary for the elaboration of juvenile play in rats. Anesthetization of the dorsal body surface of juvenile rats with xylocaine reduced the frequency of pinning, an indicator variable for play, by 35% to 70%, while motivation to play, measured by dorsal contacts, an index of play solicitation, remained largely intact. These data suggest that dorsal body surface anesthetization impairs the ability of juvenile rats to perceive and/or respond to playful gestures. When untreated animals were paired with xylocaine-treated animals, the xylocaine-treated animals consistently pinned the …

Spatial And Temporal Response Patterns On The Eight-Arm Radial Maze, Robert H.I. Dale

Scholarship and Professional Work - LAS

Six maze-experienced hooded rats were timed during five trials on which they collected water from all arms of an eight-arm radial maze, then made five more choices. All subjects frequently exhibited a “task-completion pause:” The subjects rarely spent more than 1 sec in the center of the maze between choices until they had entered all eight arms, then stopped in the center of the maze. In contrast, the time spent in each arm gradually increased until all of the water had been obtained, then decreased slightly. Four subjects began every trial by choosing eight consecutive adjacent arms. The task-completion pause …

Limitations On Spatial Memory In Mice, Robert H.I. Dale, Martin Bedard

Scholarship and Professional Work - LAS

Rats have an impressive ability to remember locations they have visited. Two experiments used an eight-arm radial maze to determine whether mice showed two important characteristics of this spatial memory: its durability, and its dependence on stimuli outside the maze (extreme stimuli). In Experiment 1, food-deprived mice were allowed to eat from four of the eight arms of the maze then, after delays of 5 sec, 1 min, or 5 min, they were permitted to choose the remaining arms. Choice accuracy declined significantly with the longer delays, but always remained above chance. In Experiment 2, the maze was rotated 180° …

The Relationship Between Whole Brain Catecholamine Depletion In Carassius Auratus And The Exposure To Inescapable Shock In A Learned Helplessness Paradigm, Roderick J. Misunis

Masters Theses

Learned helplessness is a psychological concept that describes the subsequent escape-avoidance behavior of experimental subjects who are exposed to uncontrollable stressors. Subjects after treatment are unable to respond in situations where escape is possible. Two major theorists, Seligman and Weiss, have proposed explanations concerning the phenomena. Seligman feels that the subject is unable to respond due to the fact that the exposure to an uncontrollable stressor has caused him to learn to be "helpless". Weiss feels that the inability to respond can best be described by alterations in the subject's brain neurochemistry, specifically the neurotransmitter norepinephrine. This paper is an …

Validation Of The Tactual Performance Test As An Organicity Screening Device, Stephen C. Lippold

Masters Theses

Organicity screening devices are those psychometric tests used to detect brain dysfunction during the initial assessment. The characteristics of such tests were listed and ones currently being used were reviewed. The review concentrated on the validity and clinical utility of these organicity tests. From the review it was concluded that the validity has not been thoroughly established, partially because weak criteria have been used. It was also concluded that current screening tests have questionable clinical utility, since an inordinant number of organically impaired people are not detected by the tests. The concept of organicity was discussed, and the Tactual Performance …

Material-Specific Processes In Tactile Short-Term Memory, Christina Anne Meyers

Dissertations and Theses

Studies concerning tactile short-term memory (short-term memory or the sense of touch) have often been contradictory. Some of these studies support the existence of modality-specific tactile memory, a separate, independent storage system for tactile information. Other studies do not support such a system. Further, confusion has arisen regarding the tactile test materials, since many of them use common shapes which are easily labeled verbally. It is hypothesized that information which can be labeled is stored in material-specific verbal memory in the left hemisphere, while patterned or spatial information is stored in material-specific nonverbal memory in the right hemisphere.

This paper …

The Relative Attenuation Of Self-Stimulation, Eating And Drinking Produced By Dopamine-Receptor Blockade, E. T. Rolls, B. J. Rolls, P. H. Kelly, S. G. Shaw, R. J. Wood, Robert H.I. Dale

Scholarship and Professional Work - LAS

Spiroperidol, which blocks dopamine (DA) receptors, attenuated self-stimulation of the nucleus accumbens, septal area, hippocampus, anterior hypothalamus and ventral tegmental area. Dopamine is thus involved in self-stimulation of many sites (in addition to the lateral hypothalamus). The attenuation was not a simple motor impairment of the speed of bar-pressing in that the nucleus accumbens and septal self-stimulation rates were lower than those in treated animals self-stimulating at other sites (Experiment 1). Feeding was partly attenuated, and drinking was much less attenuated by the spiroperidol. Since the rats bar-pressed for brain- stimulation reward, chewed pellets to eat, and licked a tube …

Molecular Transfer Of Acquired Discrimination By Proteinaceous Extract, Robert L. Sayre

Theses, Dissertations and Capstones

Early investigators of the molecular basis of memory suggested a unique function for the nucleic acids in learning and memory, with base changes in RNA being the most popular mechanism in representing memory for experiential events. Subsequent research has led to the hypothesis that RNA is intermediary in the general action of cells, but some researchers continue to think of RNA as providing a unique contribution during learning.

Some Parameters Of The Second-Order Conditioning Of Fear In Rats, Alan Kamil

Papers in Behavior in Biological Sciences

The effects of CS1 duration, partial reinforcement, and trace conditioning on second-order conditioned suppression were investigated, employing 64 rats as Ss. In Experiment 1, the clearest second-order conditioning was obtained when CS1 duration was the same during both the first- and the second-order conditioning phases of the experiment. In Experiment 2, somewhat better second-order conditioning was obtained when first-order conditioning had been under conditions of partial reinforcement, delay CS-US pairing. In neither experiment were CS1 suppression and CS2 suppression during second-order testing well correlated. This aspect of the results raised the question of the influence of nonclassical conditioning factors on …