Neuroscience and Neurobiology Commons^™

Restorative Potential And Working Memory Capacity Of Exposure To Vegetation In Indoor Built Environments, Jee Heon Rhee

Theses and Dissertations

This research seeks to understand how natural elements – specifically, vegetation in the indoor environment - influence people’s ability to restore attention and working memory capacity. Previous research demonstrates the benefits of nature on human beings in various ways. For instance, numerous studies show the positive effects of nature on stress reduction (Hartig, Mang, & Evans, 1991; Ulrich et al., 1991) and attention restoration (Staats, Kieviet, & Hartig, 2003). However, most of these studies focus on the effect of nature in outdoor settings. Relatively few studies focus on the presence of natural elements indoors. This is an important gap in …

Inactivation Of Nucleus Reuniens Impairs Spatial Memory In Mice, Miranda Schwabe

Theses and Dissertations

Episodic memory is a complex process requiring input from several regions of the brain. Coordinated activity in the Dorsal Hippocampus (DH) and medial Prefrontal Cortex (mPFC) is required for episodic memory consolidation. Our laboratory demonstrated that simultaneous subthreshold chemogenetic inactivation of the dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) impairs the consolidation of object placement (OP) and object recognition (OR) memory in female mice (Tuscher et al., 2018), suggesting that these two brain regions work in concert to promote memory consolidation. However, the mechanisms through which the DH and mPFC interact to promote memory consolidation remain poorly understood. A …

Spirituality As A Moderator Between Ptss And Cardiovascular Reactivity, Kriti Sharda

Honors Scholar Theses

Posttraumatic stress symptoms (PTSS) can be distressing and produce robust cardiovascular symptoms, such as increased heart rate and blood pressure, which have been implicated in higher risk of developing cardiovascular disease (CVD). Identifying factors that may reduce symptoms may suggest therapeutic strategies. One such potential factor is spirituality, given that spirituality is associated with both reducing PTSS and with preventing or improving CVD. We sampled 63 young college women who indicated being exposed to unwanted sexual contact. We asked them to write about their experience while we took heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) …

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder, Carissa Weis

Theses and Dissertations

Posttraumatic stress disorder (PTSD) is a heterogenous psychological disorder that may result from exposure to a traumatic event. Using functional magnetic resonance imaging (fMRI), symptoms of PTSD have been associated with aberrations in brain networks that emerge in the absence of a given cognitive demand or task, called resting state networks. Most previous research in resting state networks and PTSD has focused on aberrations in the static functional connectivity among specific regions of interest (ROI) in the brain and within canonical networks constrained by a priori hypotheses. However, dynamic fMRI, an approach that examines changes in brain network characteristics over …

Historical Trauma Response Scores As A Function Of Unresolved Grief And Substance Use Disorder In American Indian Populations, Andrew R. Saunders

Undergraduate Research Symposium

Abstract

Researchers are interested in the outcomes of interventions, specifically, measuring historical trauma (HT) among American Indian/Alaska Native communities and the long-term distress and substance abuse as a result of historical trauma response (HTR). Previous literature has implicated limitations in the clinical conceptualization of the relationship between intergenerational transfer of HTR and substance abuse. The aim of the current study is to examine treatment efficacy of 50 homosexual, American Indian males randomized to a culturally-adapted juxtaposition of (1) Group Interpersonal Psychotherapy (IPT), (2) Cognitive Processing Therapy (CPT), and (3) Historical Trauma and Unresolved Grief Intervention (HTUG), or (4) waitlisted on …

Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma

LSU Doctoral Dissertations

The neurohypophysial hormone oxytocin is involved in the regulation of social behaviors, including social recognition, pair bonding, and sex-specific parental behaviors in a variety of species. Oxytocin triggers these social behaviors by binding to oxytocin receptors (OXTR) in various parts of the brain. Oxytocin-induced sex-typical behavior, therefore, suggests a sexual dimorphic distribution of OXTR in the brain. In recent years, the oxytocin system in the brain received tremendous attention as a potential pharmacological target for treatment of many psychiatric disorders, such as anxiety, autism spectrum disorders, and even sex-specific psychiatric disorder like postpartum depression (PPD). An important problem and a …

Is Executive Function The Universal Acid?, Stephen J. Morse

All Faculty Scholarship

This essay responds to Hirstein, Sifferd and Fagan’s book, Responsible Brains (MIT Press, 2018), which claims that executive function is the guiding mechanism that supports both responsible agency and the necessity for some excuses. In contrast, I suggest that executive function is not the universal acid and the neuroscience at present contributes almost nothing to the necessary psychological level of explanation and analysis. To the extent neuroscience can be useful, it is virtually entirely dependent on well-validated psychology to correlate with the neuroscientific variables under investigation. The essay considers what executive function is and what the neuroscience adds to our …

Predictors Of Pathology Smartphone Use: Reward Processing, Depressive Symptoms, And Self-Control, Ashley Dapore, Robert West, Carl Ash, Bridget Kirby, Kaitlyn Malley, Shasha Zhu

Annual Student Research Poster Session

The widespread adoption of smartphones that allow us to work, engage with friends and family, and pursue leisure activities has been associated with the emergence of pathological smartphone use wherein individuals experience anxiety and depressive symptoms when separated from their devices and may be more likely to engage in risky behavior while using their phone. Consistent with the broader literature on behavioral addictions, smartphone pathology is associated with increased depressive symptoms and decreased self-control. The current study builds upon a foundation of evidence from studies of pathological technology use including video games, the Internet, and social media to explore the …

Winning In Weight-Loss: The Interaction Of Conscientiousness And Perceived Autonomy, Jason M. Curtis, Marc Lochbaum

Journal for Sports Neuroscience

ABSTRACT

Background

Understanding determinants for weight-loss is a national priority. Obesity is an epidemic with serious health consequences. Most of today’s obesity and overweight problems are being attributed to poor diets and not enough physical activity. These problems show no signs of slowing down with the behaviors of most Americans. The phenomenon of “The Biggest Loser” (different variants of weight-loss programs that consist of group exercise participation and nutrition therapy to elicit weight-loss, and hopefully behavior change) has spawned many variants in commercial health clubs. This prospectus study examined the direct and interactive or moderated effects of known determinants of …

The Cognitive Thalamus: Source Analysis Of Scene Working Memory Delay Activity, Bernard A. Gomes

Dissertations, Theses, and Capstone Projects

Working Memory represents a limited-capacity store for maintaining information and manipulating the store's contents over a short period for the guidance of goal-directed behavior. Working Memory is an essential component of executive functions that are intricately associated with the prefrontal cortex (PFC). The PFC has been implicated in maintaining task-related information online for brief periods in the absence of relevant information. This active maintenance phase is called the delay period that occurs between encoding and retrieval of the stimulus. Previous studies have attempted to understand the relationship between working memory and the PFC, especially during the delay or maintenance phase …

Shared Neural Substrates Of Perception And Memory: Testing The Assumptions And Predictions Of The Representational-Hierarchical Account, D. Merika W. Sanders

Doctoral Dissertations

Proponents of the representational-hierarchical (R-H) account claim that memory and perception rely on shared neural representations. In the ventral visual stream, posterior brain areas are assumed to represent simple information (e.g. low-level image properties), but the complexity of representations increases toward more anterior areas, such as inferior temporal cortex (e.g., object-parts, objects), extending into the medial temporal lobe (MTL; e.g. scenes). This view predicts that brain structures along this continuum serve both memory and perception; a structure’s engagement is determined by the representational demands of a task, rather than the cognitive process putatively involved. In a neuroimaging study, I searched …

The Temporal Dynamics Of Ensemble Perception, Michael L. Epstein

Dissertations, Theses, and Capstone Projects

The striking disparity between the subjective richness of experience and the considerable limitations of perceptual processing has emerged as an essential, enduring question in both vision science and philosophy of mind. A potential solution to this issue is ensemble perception: the ability for the visual system to compute the statistical summaries of object groups, effectively compressing an otherwise overwhelming amount of information. Previous work has supported that ensemble statistics can be perceived quickly and accurately for a wide range of object features. This has motivated models of ensemble perception as an early process in vision, providing an initial sense of …

Rehabilitative Movement Approaches And Dance Interventions In Parkinson’S Disease, Cecilia Fontanesi

Dissertations, Theses, and Capstone Projects

The scope of this work is to address the functional deficits and symptoms experienced by those living with Parkinson’s Disease through movement interventions.

Chapter 1 offers a brief overview of current pharmacotherapy and rehabilitation approaches in Parkinson’s, focusing on dance in particular as a movement intervention that may be particularly suited to this population.

Chapter 2 focuses on brain plasticity and motor learning in PD, reporting the effects of rTMS applied after the acquisition of a motor skill. In this study, adaptation tested in patients with PD was comparable in the sham and TMS sessions, while retention indices tested on …

Neurodevelopmental Mechanisms Of Adverse Trauma Outcomes In Emerging Adulthood, Olena Kleshchova

Dissertations, Theses, and Capstone Projects

Background: Exposure to traumatic stress and adversity during the formative years of development can have adverse effects on mental health, neuroendocrine stress system function, and the brain, that persist into adulthood. One candidate mechanism that might confer vulnerability to enduring adverse outcomes of early life trauma is disruption of normal brain maturation. As the brain matures, functional interactions among brain regions change until the functional brain architecture (i.e., the functional connectome) reaches a mature state in adulthood. Given that different neural circuits have distinct developmental trajectories and sensitive periods, traumatic stress at a given point in development might have …

A Glance At The Mirror: Ensemble Perception Of Symmetry, Gene Jerskey

Dissertations, Theses, and Capstone Projects

A growing body of research has demonstrated the ability of subjects to extract representative statistics from visual ensembles, images of similar but distinct groups of objects, without conscious effort or attention focused on individual members of the ensemble. When presented with ensembles, subjects have been able to accurately report the mean, range, and even distribution of various features in the ensemble. Research into ensemble perception, as it has become known, has divided mainly into studies of either low-level features, such as orientation, motion, and color, which are processed in early visual areas, at least for individual objects, or high-level features, …

Sex/Gender Differences In Serial Position Profiles In Patients With Mild Cognitive Impairment And Healthy Controls, Emnet Z. Gammada

Dissertations, Theses, and Capstone Projects

Introduction: Alzheimer’s disease disproportionately affects more women, but paradoxically, men have a higher incidence of Mild Cognitive Impairment (MCI). Researchers have suggested that women’s verbal memory advantage across the lifespan reflects better premorbid skills, which then require more neurodegeneration to manifest early clinical impairment. To date, measurement of sex differences in verbal memory have used total list scores. We proposed that a granular examination of serial position effects (SPE) in list-learning can refine the source of sex/gender differences.

Methods: A cross-sectional analysis of participants with Mild Cognitive Impairment (MCI) and Healthy Controls (HC) was examined from the Alzheimer’s Disease Neuroimaging …

Structural And Functional Brain Markers Of Trauma-Related Symptoms, Glenn Blessington

Dissertations, Theses, and Capstone Projects

The neurocircuitry model of posttraumatic stress disorder suggests an association between trauma-related symptoms and abnormalities in the structure and function of limbic and prefrontal brain regions. Evidence also suggests that these structural and functional abnormalities are related. We tested the relation between whole brain white matter integrity, resting-state functional connectivity of a fronto-limbic network, and trauma-related symptoms in 22 trauma-exposed women. We hypothesized that components of whole brain white matter would correlate with components of resting connectivity within a fronto-limbic network. We used parallel independent component analysis (pICA) to test the associations between whole brain fractional anisotropy (FA) maps and …

Analysis Of Newspaper Coverage Of Psilocybin From January 1, 1989 To December 31, 2019, Dax Oliver

Dissertations, Theses, and Capstone Projects

Psilocybin is a chemical compound that has received a lot of attention from medical researchers in recent years. However, this research is not merely a medical issue but a social and political one as well. In the 1960s, psilocybin and other psychedelic compounds were widely ingested outside of clinical settings. This alarmed some of the American public, resulting in severe legal restrictions on psilocybin use and research.

Today, many psilocybin advocates hope that it will avoid the negative public sentiment of the 1960s. To help gauge public sentiment about other psychoactive compounds, some studies have examined newspaper coverage, but there …

Investigating The Combined Effects Of Whole Body Vibration And Vestibular Stimulation On Spasticity And Dystonia In Cerebral Palsy, Peter A. Michael

Dissertations

This study identifies and addresses three voids and potential shortcomings associated with the classification, assessment and management of Cerebral Palsy (CP). These concerns should not undermine the significant advancement that has been made in this specific branch of rehabilitation, but addressing them is necessary. Cerebral Palsy is a group of motor impairments due to hypoxic-ischemic brain damage around the time of birth and very commonly manifests as excessive muscle tone and poor motor control. There are classifications within CP including spasticity and dystonia.

First, a level of discrepancy is present in the classification of CP between the clinical and research …

Comparison Of Longitudinal Changes In Resting State Functional Magnetic Resonance Imaging Between Alzheimer’S And Healthy Controls, Berk Can Yilmaz

Theses

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related …

The Effects Of Adolescent Chronic Mild Stress: In Female Wistar-Kyoto Rats, Anna Hallowell

The Journal of Purdue Undergraduate Research

Despite years of research to understand under-lying mechanisms and develop more effective treatment approaches for mood disorders, numerous challenges exist. Many chronic stress models are used to study mood disorders, how-ever the majority have been established with adult males. This is problematic considering that affective disorders are more common in women, and generally develop during late adolescence. Studies have indicated fundamental behavioral, physiological, and neural differences between males and females in response to the same external stressors, furthering a need to develop sex-specific paradigms to accurately model the etiology of mood disorders in females. The Wistar-Kyoto (WKY) rat strain is …

Feeling-Of-Knowing Experiences Breed Curiosity, Gregory Brooks

Electronic Thesis and Dissertation Repository

It is well-established that curiosity has benefits for learning. Less is known about potential links between curiosity and memory retrieval. In theoretical work on metacognition it has been argued that retrieval experiences that occur during memory search can exert control over behaviour. States of curiosity, which can be defined as behavioural tendencies to seek out information, may play a critical role in this control function. We conducted two experiments to address this idea, focusing on links between feeling-of knowing (FOK) experiences, memory-search duration, and subsequent information-seeking behaviour. We administered an episodic FOK paradigm that probed memory for previously studied arbitrary …

Preliminary Evidence Of The Role Of Medial Prefrontal Cortex In Self-Enhancement: A Transcranial Magnetic Stimulation Study, Birgitta Taylor-Lillquist, Vivek Kanpa, Maya Crawford, Mehdi El Filali, Julia Oakes, Alex Jonasz, Amanda Disney, Julian Keenan

Department of Biology Faculty Scholarship and Creative Works

Humans employ a number of strategies to improve their position in their given social hierarchy. Overclaiming involves presenting oneself as having more knowledge than one actually possesses, and it is typically invoked to increase one’s social standing. If increased expectations to possess knowledge is a perceived social pressure, such expectations should increase bouts of overclaiming. As the medial prefrontal cortex (MPFC) is sensitive to social pressure and disruption of the MPFC leads to decreases in overclaiming, we predicted that transcranial magnetic stimulation (TMS) applied to the MPFC would reduce overclaiming and the effects would be enhanced in the presence of …

How Natural Materials Affect Our Perception Of The Built Environment, Iryna Demianiuk

English Language Institute

Our daily life is shaped by the emotions we feel, and our emotions are highly dependent on the environment we live in. Those connections have been developing through the whole history of humankind, starting with the feeling of shelter near bonfires in caves. Today, we can discover neural responses to environmental conditions and even certain materials around us. Those findings have allowed architects and neuroscientists to work more closely together, and, through that collaboration, the new field of neuroarchitecture appeared. This relatively young discipline explores the way our brain responds to the environmental stimuli we are facing, and how different …

Clusters Of Individuals Experiences Form A Continuum Of Persistent Non-Symbolic Experiences In Adults, Jeffery A. Martin

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Persistent forms of nondual awareness, enlightenment, mystical experience, and so forth (Persistent Non-Symbolic Experience) have been reported since antiquity. Though sporadic research has been performed on these experiences, the scientific literature has yet to report a large-scale cognitive psychology study of this population. Method: Assessment of the subjective experience of 319 adult participants reporting persistent non-symbolic experience was undertaken using 6-12 hour semi-structured interviews and evaluated using grounded theory and thematic analysis. Results: Five core, consistent categories of change were uncovered: sense-of-self, cognition, affect, perception, and memory. Participants’ reports formed phenomenological groups in which the types of change …

The Impact Of Task Load On Neural Entrainment To Attended Speech: A Dual-Task Magnetoencephalography (Meg) Paradigm, Michelle Tamar Kassel

Theses and Dissertations

Speech comprehension in a noisy environment requires active cognitive control mechanisms to select the relevant speech signal while filtering out irrelevant distractions. When processing speech in a multitask scenario, neural resources underlying cognitive control are considerably burdened and interfering information becomes more difficult to ignore. The present study utilized magnetoencephalography (MEG) to investigate the impact of multitasking on selective attention to speech. Twenty healthy adults performed a multitask paradigm with varying levels of both competing auditory distraction and concurrent visual working memory load. While increased visual working memory load was associated with reduced selective attention to speech in both the …

The Association Of Aerobic Fitness With Resting State Functional Connectivity And Verbal Learning And Memory In Healthy Young Adults, Kyle Joseph Jennette

Theses and Dissertations

The beneficial effects of exercise and cardiopulmonary fitness on general health, quality of life, and reduction of mortality are well known in older adults. There is evidence to support the positive effects of exercise and aerobic fitness on psychiatric and neurocognitive function in children, adults, and older adults. Indeed, many studies have explored the positive effects of aerobic fitness on slowing cognitive decline associated with normal and pathological aging. However, comparatively fewer empirical studies in the literature exist to support and understand the effects of aerobic fitness on the developing brain, particularly during adolescence and young adulthood, especially as it …

Shaped By The Environment: The Influence Of Childhood Trauma Exposure, Individual Socioeconomic Position, And Neighborhood Disadvantage On Brain Morphology, Elisabeth Kathleen Webb

Theses and Dissertations

The relationship between an individual’s socioeconomic position (SEP) and their overall physical and mental health has been well demonstrated. Far less is known about how area-level factors, such as neighborhood disadvantage, “get under the skin”. Previous research indicates lower SEP and childhood trauma negatively effects brain structure and function. The hippocampus, amygdala, and ventromedial prefrontal cortex (vmPFC) are particularly vulnerable to adversity. The current study investigated how individual SEP, childhood trauma, and neighborhood disadvantage impact these structures. Two-hundred and fifteen individuals were recruited from an Emergency Department in southeastern Wisconsin. Two-weeks post-traumatic injury, participants completed a structural magnetic resonance imaging …

Effects Of Prenatal Exposure To Phenobarbital On Verbal Abilities In School-Aged Children, Jocelyn M. Lutes

Graduate Masters Theses

Phenobarbital is one of the oldest medications used for the treatment of epilepsy. Although its use has declined in many developed nations, phenobarbital is still a first-line treatment in several developing countries across the globe. If possible, current American Academy of Neurology guidelines advise against the use of phenobarbital during pregnancy due to an increased risk for structural malformations. However, less is known about the risk that prenatal exposure to phenobarbital poses to the cognitive and behavioral development of the child. Adams et al (in progress) have shown that, in comparison to demographically matched controls, children prenatally exposed to phenobarbital …

Consider The Agent In The Arthropod, Nicolas Delon, Peter Cook, Gordon Bauer, Heidi Harley

Animal Sentience

Whether or not arthropods are sentient, they can have moral standing. Appeals to sentience are not necessary and retard progress in human treatment of other species, including invertebrates. Other increasingly well-documented aspects of invertebrate minds are pertinent to their welfare. Even if arthropods are not sentient, they can be agents whose goals—and therefore interests—can be frustrated. This kind of agency is sufficient for moral status and requires that we consider their welfare.