Neuroscience and Neurobiology Commons^™

High-Resolution Spectral Sleep Analysis Reveals A Novel Association Between Slow Oscillations And Memory Retention In Elderly Adults, Makoto Kawai, Logan D. Scheider, Omer Linkovski, Joshua Jordan, Rosy Karna, Sophia Pirog, Isabelle Cotto, Casey Buck, William J. Giardino, Ruth O'Hara

Psychology | Faculty Scholarship

Objective: In recognition of the mixed associations between traditionally scored slow wave sleep and memory, we sought to explore the relationships between slow wave sleep, electroencephalographic (EEG) power spectra during sleep and overnight verbal memory retention in older adults.

Design, Setting, Participants, and Measurements: Participants were 101 adults without dementia (52% female, mean age 70.3 years). Delayed verbal memory was first tested in the evening prior to overnight polysomnography (PSG). The following morning, subjects were asked to recall as many items as possible from the same List (overnight memory retention; OMR). Partial correlation analyses examined the associations of delayed verbal …

Implicit Bias Through The Lens Of Electroencephalography, Hope Cooper

Behavioral Neuroscience Honors Papers

Unconscious or implicit bias is a part of everyday life. All human beings both exhibit implicit bias and (some more than others) are also the victims of it. Due to the way humans have evolved implicit bias will never be something that ceases to exist. Thus, it is important that neuroscience and social science closely study how it works and how to curb the behaviors caused by implicit bias. In the following research EEG (electroencephalography) was used alongside a weapons IAT (Implicit Association Test) to examine specific neural components that may correlate with higher bias scores on the IAT. Specific …

Invertebrates Should Be Given Ethical Consideration, Marie-Claire Cammaerts

Animal Sentience

Invertebrates are far more numerous than vertebrates. Most of them are essential to the survival of humanity. Their physiology, behavior, know-how, and cognitive abilities are often as complex as those of vertebrates. Invertebrates should be considered and studied as are vertebrates, i.e., ethically, and cautiously.

Diverse Autonomic Nervous System Stress Response Patterns In Childhood Sensory Modulation, Jacquelyn Christensen, Heather Wild, Erin S. Kenzie, Wayne Wakeland, Deborah Budding, Connie Lillas

Complex Systems Faculty Publications and Presentations

The specific role of the autonomic nervous system (ANS) in emotional and behavioral regulation—particularly in relation to automatic processes—has gained increased attention in the sensory modulation literature. This mini-review article summarizes current knowledge about the role of the ANS in sensory modulation, with a focus on the integrated functions of the ANS and the hypothalamic-pituitary-adrenal (HPA) axis and their measurement. Research from the past decade illustrates that sympathetic and parasympathetic interactions are more complex than previously assumed. Patterns of ANS activation vary across individuals, with distinct physiological response profiles influencing the reactivity underlying automatic behavioral responses. This review article advances …

Book Review: Was Yosef On The Spectrum By Samuel J. Levine, Ian Hale, Ph.D.

Touro Law Review

No abstract provided.

Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray

Honors Theses

Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …

Executive Function Deficit As A Precursor To Memory Impairments In Hapoe4 Transgenic Rats, Kaitlin Mcmanus

Honors Theses

The hApoE4 allele is one of the strongest genetic risk factors for Alzheimer’s disease (AD). It underlies amyloid-bdeposits and neurofibrillary tangles, the two hallmarks associated with AD pathology, and is subsequently associated with AD symptomology. Despite its importance, no rat animal studies to date use hApoE4 knock-ins. In addition to this deficit in the field of AD literature, the vast majority of AD studies focus on memory, even though executive function deficits may precede memory impairments in AD, and may be a predictor of AD development. Thus, the present study addressed these gaps in AD research by investigating the behavioral …

Covid-19, Evolution, Brains And Psychology, Frederick Toates

Animal Sentience

Attention needs to be directed to the processes that control behavior in humans and the adaptive problems that they solved in our early evolutionary environment. The evolutionary mismatch between the current environment and the human brain can yield important insights into the problems that beset us in the context of environmental degradation and nonhuman animal welfare.

Inhibition Of Pain Or Response To Injury In Invertebrates And Vertebrates, Matilda Gibbons, Sajedeh Sarlak

Animal Sentience

In certain situations, insects appear to lack a response to noxious stimuli that would cause pain in humans. For example, from the fact that male mantids continue to mate while being eaten by their partner it does not follow that insects do not feel pain; it could be the result of modulation of nociceptive inputs or behavioural outputs. When we try to infer the underlying mental state of an insect from its behaviour, it is important to consider the behavioural effects of the associated physiological and neurobiological mechanisms.

Zoonotic Realism, Computational Cognitive Science And Pandemic Prevention, Tyler Davis, Molly E. Ireland, Jason Van Allen, Darrell A. Worthy

Animal Sentience

Using animals in food and food production systems is one of many drivers of novel zoonoses. Moving toward less dependence on animal proteins is a possible avenue for reducing pandemic risk, but we think that Wiebers & Feigin’s proposed change to food policy (phasing out animal meat production) is unrealistic in its political achievability and its current capacity to feed the world in a cost-effective and sustainable manner. We suggest that improvements in communication strategies, precipitated by developments in computational cognitive neuroscience, can lead the way to a safer future and are feasible now.

Insect Sentience And The Rise Of A New Inclusive Ethics, David Baracchi, Luigi Baciadonna

Animal Sentience

Welfare protections for vertebrates are grounded in the belief that vertebrates are sentient and capable of feeling whereas invertebrates are not. We agree with Mikhalevich & Powell that the exclusion of small-brained invertebrates from bioethics is not warranted by the current state of the scientific evidence. The choice to promote protection for certain invertebrates should be based on the Animal Sentience Precautionary Principle (ASPP). This principle should not prevent us from conducting experimental research with non-human animals to advance knowledge. However, we believe that it is important to outline practical guidelines to manage the wellbeing of invertebrates, while accumulating further …

Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia

Open Access Theses & Dissertations

Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to …

Comparative Cognition And Nonhuman Individuality, Catia Correia Caeiro

Animal Sentience

Commentators Washington (2019) and Tiffin (2019) point out that the individual vs. collective dichotomy is much more complex than what is considered in the target article. This commentary will focus on why individuals are more important than collectives. Species differences in cognition and emotional processes and individuals’ feelings and experiences need to be taken into account.

Whether Invertebrates Are Sentient Matters To Bioethics And Science Policy, Michael L. Woodruff

Animal Sentience

Mikhalevich & Powell provide convincing empirical evidence that at least some invertebrates are sentient and hence should be granted moral status. I agree and argue that functional markers should be the primary indicators of sentience. Neuroanatomical homologies provide only secondary evidence. Consensus regarding the validity of these functional markers will be difficult to achieve. To be effective in practice, functional markers of sentience will have to be tested and accepted species by species to overcome the implicit biases against extending moral status to invertebrates.

Ideology And Predictive Processing: Coordination, Bias, And Polarization In Socially Constrained Error Minimization, Nathan E. Wheeler, Suraiya Allidina, Elizabeth U. Long, Stephen P. Schneider, Ingrid J. Haas, William A. Cunningham

Department of Political Science: Faculty Publications

Recent models of cognition suggest that the brain may implement predictive processing, in which top-down expectations constrain incoming sensory data. In this perspective, expectations are updated (error minimization) only if sensory data sufficiently deviate from these expectations (prediction error). Although originally applied to perception, predictive processing is thought to generally characterize cognitive architecture, including the social cognitive processes involved in ideological thinking. Scaling up these simple computational principles to the social sphere outlines a path by which group members may adopt shared ideologies and beliefs to predict behavior and cooperate with each other. Because ideological judgments are of specific interest …

Serotonin 5-Ht2a And 5-Ht2c Receptors Regulate Rat Maternal Behavior Through Distinct Behavioral And Neural Mechanisms, Jun Gao, Lina Nie, Yu Li, Ming Li

Department of Psychology: Faculty Publications

Serotonin 5-HT_2A and 5-HT_2C receptors play important yet distinctive roles in the regulation of rat maternal behavior. The present study investigated their neural substrates and explored the possible behavioral mechanisms (i.e., behavioral organization or maternal motivation). Sprague-Dawley postpartum females were microinjected with either a selective 5-HT_2A agonist (TCB-2, 0.4 or 4.0 μg/side) or a 5-HT_2C agonist (MK212, 2.5 or 5.0 μg/side) into the medial prefrontal cortex (mPFC) or ventral tegmental area (VTA). Ten and 60 min later, their maternal activities were observed in the home cage; and their motivational responses towards pups were examined in a …

Mechanisms Of Value-Biased Prioritization In Fast Sensorimotor Decision Making, Kivilcim Afacan-Seref

Dissertations and Theses

In dynamic environments, split-second sensorimotor decisions must be prioritized according to potential payoffs to maximize overall rewards. The impact of relative value on deliberative perceptual judgments has been examined extensively, but relatively little is known about value-biasing mechanisms in the common situation where physical evidence is strong but the time to act is severely limited. This research examines the behavioral and electrophysiological indices of how value biases split-second perceptual decisions and the possible mechanisms underlying the process. In prominent decision models, a noisy but statistically stationary representation of sensory evidence is integrated over time to an action-triggering bound, and value-biases …

Problems With Basing Insect Ethics On Individuals’ Welfare, Susana Monsó, Antonio J. Osuna-Mascaró

Animal Sentience

In their target article, Mikhalevich & Powell (M&P) argue that we should extend moral protection to arthropods. In this commentary, we show that there are some unforeseen obstacles to applying the sort of individualistic welfare-based ethics that M&P have in mind to certain arthropods, namely, insects. These obstacles have to do with the fact that there are often many more individuals involved in our dealings with insects than our ethical theories anticipate, and also with the fact that, in some sense, some insects count as more than an individual and, in another sense, they sometimes count as less than an …

Lessons From Miniature Brains: Cognition Cheap, Memory Expensive (Sentience Linked To Active Movement?), Giorgio Vallortigara

Animal Sentience

Studies on invertebrate minds suggest that the neural machinery for basic cognition is cheap, and that bigger brains are probably associated with greater memory storage rather than more advanced cognition. Sentience may be linked to feedforward mechanisms (Reafferenzprinzip) that allow organisms with active movement to distinguish active and passive sensing. Invertebrates may offer special opportunities for testing these hypotheses.

How Does Eye Movement Desensitization And Reprocessing (Emdr) Work? An Examination Of The Potential Mechanisms Of Action, Sara Forster

Theses and Dissertations

A mounting body of evidence suggests that Eye Movement Desensitization and Reprocessing therapy (EMDR) is successful in reducing the impact of posttraumatic symptoms. Although the exact mechanisms of action remain unknown, theories from the psychological to the neuroscientific continue to emerge, expand, and evolve. This study will examine four of the most prominent theories to date and weigh the evidence for and against each one. It will also review, compare, and contrast the theories, evaluate the research supporting each one, and propose the most likely explanation for EMDR's success given the state of the research. Neurobiological mechanisms and correlates as …

Ethical Considerations For Invertebrates, Scarlett R. Howard, Matthew R.E. Symonds

Animal Sentience

Mikhalevich & Powell (2020) have built on the discussion about which species deserve inclusion in animal ethics and welfare considerations. Here, we raise questions concerning the assessment criteria. We ask how to assess different species for their ability to fulfill the criteria, which criteria are most important, how we quantify them (absolute or on a continuum), and how non-animals such as fungi and plants fit into this paradigm.

Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze

Theses and Dissertations (Comprehensive)

Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …

What Makes An Image Memorable? Effects Of Encoding On The Mechanism Of Recognition, Asiya Gul

Theses and Dissertations (Comprehensive)

Memory is undoubtedly one of the most important processes of human cognition. A long line of research suggests that recognition relies on the assessment of two explicit memory phenomena: familiarity and recollection. Researchers who support the Dual Process Signal Detection (DPSD) model of recognition memory link the FN400 component (a negative ERP deflection peaking around 400 ms at frontal electrodes) with familiarity; however, it is currently unclear whether the FN400 reflects familiarity or implicit memory. Three event-related potentials (ERP) studies were conducted to determine whether implicit memory plays a role in setting up encoding strategies, and how these encoding strategies …

Exploring Eight-Armed Intelligence Through Film, Tierney M. Thys

Animal Sentience

Mather (2019) provides a rich overview of the elements underlying octopus cognition and behavioral flexibility. Recently, two remarkable natural history films, My Octopus Teacher and The Octopus in My House have explored intimate human-octopus relationships with a wild (Octopus vulgaris) and a captive octopus (Octopus cyanea) respectively. Both films show rare behaviors that offer observations to test new hypotheses as well as a novel perspective on our own human relationships and place within the natural world. An interview with filmmaker Craig Foster from My Octopus Teacher reveals the profound and transformative power of forming a trusting …

Visual Modulation Of Resting State Α Oscillations, Kelly Webster, Tony Ro

Publications and Research

Once thought to simply reflect passive cortical idling, recent studies have demonstrated that α oscillations play a causal role in cognition and perception. However, whether and how cognitive or sensory processes modulate various components of the α rhythm is poorly understood. Sensory input and resting states were manipulated in human subjects while electroencephalography (EEG) activity was recorded in three conditions: eyes-open fixating on a visual stimulus, eyes-open without visual input (darkness), and eyes-closed without visual input (darkness). We show that α power and peak frequency increase when visual input is reduced compared to the eyes open, fixating condition. These results …

The Influence Of Neural Reward Processing On Memory In Depression, Nathan M. Hager

Psychology Theses & Dissertations

Theories and research suggest that depression involves impaired reward sensitivity and a deficit in memory for rewarding stimuli. Some researchers propose that this memory deficit may result from reduced neural reward sensitivity, which impairs the encoding of reward-related memories, but few studies have directly probed this connection. Such research may benefit from examining the reward positivity (RewP), an event-related potential (ERP) previously linked to reduced reward sensitivity in depression. Undergraduates with high or low self-reported depression completed a task in which they chose one of three doors, revealing a neutral word written in a color which indicated an outcome of …

Functional Analysis In The Home Setting Of An Older Adult With Neurocognitive Disorder, Emily Norton

Masters Theses

Currently within the behavioral gerontology literature there are no published studies that include a functional assessment in the home setting. The primary goal of the present study was to address this gap by conducting a functional analysis on a challenging behavior of an older adult with neurocognitive disorder in the home. This study occurred in two phases. During phase one, researchers conducted an antecedent functional analysis on the bizarre speech of an 81-year-old female with suspected dementia across four conditions (television on, no interactions initiated; television on, interactions initiated; television off, no interactions initiated; television off, interactions initiated). Results from …

The Feedback-Related Negativity Is A Time-Dependent Brain Mechanism That Facilitates Aversive Learning: Implications For The Reinforcement Learning Frn Hypothesis, Eric Rawls

Graduate Theses and Dissertations

Organisms encode rewarding and aversive experiences through reinforcement learning, capitalizing on prediction errors (PEs), which adapt action strategies over time. Computational theories are explicit that PE signals should update action weights continuously over the course of a behavioral task, an important time-dependent variation that is eschewed in traditional neuroscience studies that average over large numbers of trials. I examined variation in reaction times and feedback-locked cortical activity over time as a function of PE to critically examine theories indicating that PE signals drive time-dependent learning. We recorded EEG while participants completed a novel reinforcement task that varied prediction error on …

The Role Of Gamma Oscillations And Cortical Inhibition In The Development Of Working Memory In Adolescence, Christopher P. Walker

Dissertations and Theses (Open Access)

Adolescence is a dynamic period of social, cognitive, and biological changes. In particular, working memory, the ability to actively encode and maintain information over a short period of time, develops early in childhood and gradually increases in capacity and stability during adolescence. The precise neurophysiological mechanism by which working memory capacity increases during adolescence is unclear. The objective of this investigation was to evaluate the role of cortical gamma-band (> 30 Hz) oscillations—which are associated with working memory in adults—for the development of working memory capacity in adolescents, and to identify the extent to which the temporal profile of gamma-aminobutyric …

Impact Of Remembering Vs. Knowing On Strength Of Belief In Neuromyths, Kailee Jackola

Mahurin Honors College Capstone Experience/Thesis Projects

As technology advances, misinformation can be spread easier than ever before. Many things the general public believe to be true are either completely false or contradict research findings. However, many people are not willing to give up their belief in false information, even if there is evidence to refute it. Neuromyths are a particular type of widespread misinformation involving incorrect beliefs about brain function (e.g., people can be either left-or right brained). Understanding the origins of neuromyths is important, because it may relate to the strength of individuals’ belief in these myths. Therefore, it is important to determine whether remembering …