Neuroscience and Neurobiology Commons^™

Comparison Of Longitudinal Changes In Resting State Functional Magnetic Resonance Imaging Between Alzheimer’S And Healthy Controls, Berk Can Yilmaz

Theses

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related …

Defining The Relationship Between Maternal Care Behavior And Sensory Development In Wistar Rats: Auditory Periphery Development, Eye Opening And Brain Gene Expression, Jingyun Qiu, Preethi Singh, Geng Pan, Annalisa De Paolis, Frances A. Champagne, Jia Liu, Luis Cardoso, Adrián Rodríguez-Contreras

Advanced Science Research Center

Defining the relationship between maternal care, sensory development and brain gene expression in neonates is important to understand the impact of environmental challenges during sensitive periods in early life. In this study, we used a selection approach to test the hypothesis that variation in maternal licking and grooming (LG) during the first week of life influences sensory development in Wistar rat pups. We tracked the onset of the auditory brainstem response (ABR), the timing of eye opening (EO), middle ear development with micro-CT X-ray tomography, and used qRT-PCR to monitor changes in gene expression of the hypoxia-sensitive pathway and neurotrophin …

‘Nouns That Cut Slices’: The Ontology And Ethics Of Stereotypes And Implicit Bias, Christiane Merritt

Arts & Sciences Graduate Student Theses and Dissertations

Stereotypes and implicit bias have long been objects of psychological study. Recently, philosophers, too, have attempted to understand stereotypes and implicit bias: what kinds of mental states or objects are they? Are stereotypes epistemically deficient or ethically suspect? How do implicit biases affect behavior, and how might these biases be changed? This dissertation takes up these and related questions, advancing accounts of stereotyping and implicit bias informed by evidence from psychology.Chapter 1 sets the stage by conducting a critical survey of the history and development of today’s most widely used measures of implicit bias. Although the history of the different …

Preliminary Evidence Of The Role Of Medial Prefrontal Cortex In Self-Enhancement: A Transcranial Magnetic Stimulation Study, Birgitta Taylor-Lillquist, Vivek Kanpa, Maya Crawford, Mehdi El Filali, Julia Oakes, Alex Jonasz, Amanda Disney, Julian Keenan

Department of Biology Faculty Scholarship and Creative Works

Humans employ a number of strategies to improve their position in their given social hierarchy. Overclaiming involves presenting oneself as having more knowledge than one actually possesses, and it is typically invoked to increase one’s social standing. If increased expectations to possess knowledge is a perceived social pressure, such expectations should increase bouts of overclaiming. As the medial prefrontal cortex (MPFC) is sensitive to social pressure and disruption of the MPFC leads to decreases in overclaiming, we predicted that transcranial magnetic stimulation (TMS) applied to the MPFC would reduce overclaiming and the effects would be enhanced in the presence of …

How Natural Materials Affect Our Perception Of The Built Environment, Iryna Demianiuk

International Programs

Our daily life is shaped by the emotions we feel, and our emotions are highly dependent on the environment we live in. Those connections have been developing through the whole history of humankind, starting with the feeling of shelter near bonfires in caves. Today, we can discover neural responses to environmental conditions and even certain materials around us. Those findings have allowed architects and neuroscientists to work more closely together, and, through that collaboration, the new field of neuroarchitecture appeared. This relatively young discipline explores the way our brain responds to the environmental stimuli we are facing, and how different …

Clusters Of Individuals Experiences Form A Continuum Of Persistent Non-Symbolic Experiences In Adults, Jeffery A. Martin

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Persistent forms of nondual awareness, enlightenment, mystical experience, and so forth (Persistent Non-Symbolic Experience) have been reported since antiquity. Though sporadic research has been performed on these experiences, the scientific literature has yet to report a large-scale cognitive psychology study of this population. Method: Assessment of the subjective experience of 319 adult participants reporting persistent non-symbolic experience was undertaken using 6-12 hour semi-structured interviews and evaluated using grounded theory and thematic analysis. Results: Five core, consistent categories of change were uncovered: sense-of-self, cognition, affect, perception, and memory. Participants’ reports formed phenomenological groups in which the types of change …

Effects Of Prenatal Exposure To Phenobarbital On Verbal Abilities In School-Aged Children, Jocelyn M. Lutes

Graduate Masters Theses

Phenobarbital is one of the oldest medications used for the treatment of epilepsy. Although its use has declined in many developed nations, phenobarbital is still a first-line treatment in several developing countries across the globe. If possible, current American Academy of Neurology guidelines advise against the use of phenobarbital during pregnancy due to an increased risk for structural malformations. However, less is known about the risk that prenatal exposure to phenobarbital poses to the cognitive and behavioral development of the child. Adams et al (in progress) have shown that, in comparison to demographically matched controls, children prenatally exposed to phenobarbital …

Consider The Agent In The Arthropod, Nicolas Delon, Peter Cook, Gordon Bauer, Heidi Harley

Animal Sentience

Whether or not arthropods are sentient, they can have moral standing. Appeals to sentience are not necessary and retard progress in human treatment of other species, including invertebrates. Other increasingly well-documented aspects of invertebrate minds are pertinent to their welfare. Even if arthropods are not sentient, they can be agents whose goals—and therefore interests—can be frustrated. This kind of agency is sufficient for moral status and requires that we consider their welfare.

Brain Complexity, Sentience And Welfare, Donald M. Broom

Animal Sentience

Neither sentience nor moral standing is confined to animals with large or human-like brains. Invertebrates deserve moral consideration. Definition of terms clarifies the relationship between sentience and welfare. All animals have welfare but humans give more protection to sentient animals. Humans should be less human-centred.

Convergent Evolution Of Sentience?, Culum Brown Prof.

Animal Sentience

Mikhalevich & Powell make a compelling case that some invertebrates may be sentient and that our moral obligations in the context of welfare should hence extend to them. Although the case is similar to that made for fishes, there is one obvious difference in that examples of invertebrate sentience probably arose independently from vertebrate sentience. We have unequivocal proof that complex cognition arose multiple times over evolutionary history. Given that cognition is our best tool for indirectly quantifying sentience, it seems highly likely that this multiple polygenesis may also have occurred for sentience. In acknowledging this, we must accept that …

An Eeg Study On Loneliness And Recognition Memory, Carmen Jia Wen Chek

Electronic Theses and Dissertations

Loneliness, the perception of unmet social needs, has been shown to relate to recollection-based recognition deficits, but the relationship between loneliness and recognition memory (i.e., recollection and familiarity) has not been thoroughly examined. The current study hypothesized that more lonely individuals would have lower recognition memory performance, specifically recollection, with smaller ERP parietal old-new effects than less lonely individuals. Forty participants, grouped into less (n = 13) and more (n = 9) lonely groups based on their R-UCLA responses, completed an associative memory task. EEG was used to assess recognition memory effects. Results showed no significant difference in …

The Effects Of Self-Esteem And Motivation On Cognitive Control, Andrea Benavides

Dissertations, Theses, and Capstone Projects

Cognitive control describes a set of mechanisms that guide behavior towards a goal (Cohen, 2017). The successful execution of cognitive control is essential for effective learning, information processing, problem solving, and academic achievement (Visu-Petra et al., 2011). The Expected Value of Control framework (EVC; Shenhav et al., 2013) suggests that control carries an inherent cost, which is weighed against the potential benefits of expending it. This cost-benefit analysis determines the direction and intensity that a goal is pursued. Importantly, motivation plays a role in this cost-benefit analysis and may function as the factor that offsets the cost of control expenditure …

Mental Associations And Music Therapy: Including The History Of Associationism And The Neurology Of Associations, Dianna Rose

Expressive Therapies Capstone Theses

Associations are formed in our minds based upon three elements: sensory experience, emotions, and memories. These associations, unique to each individual, dictate thoughts, beliefs, behaviors, and actions. Some are necessary and supportive, while others can be maladaptive. Established associations can be changed, and new associations can be formed, to align with a client’s goals. The literature presents a strong history of associationism, as well as a body of research that demonstrates the neurological processes of how mental associations are formed. There are also studies showing how music activates the brain. However, there is a lack of research which draws direct …

Transdiagnostic Multimodal Neural Correlates Of Psychosis Dimensions, Dov Bernard Lerman-Sinkoff

McKelvey School of Engineering Graduate Student Theses & Dissertations

Psychosis refers to a debilitating set of symptoms that impacts individuals, their communities, and society at large. Current psychiatric nosology treats psychosis as a categorical construct. However, recent evidence suggests that a dimensional approach that cuts across extant nosological boundaries may more accurately represent the underlying phenomena contributing to dysfunction in psychosis. One putative domain of transdiagnostic variation is cognitive control, a construct that refers to the set of functions that enable and support goal-directed behavior and regulation of one’s thoughts and actions. Previous analyses in both healthy individuals and individuals with psychosis have led to a number of findings …

Remapping Of Place Cells In The Dorsal And Ventral Hippocampus In Response To Environmental Change, Aditi Anam

Honors Scholar Theses

The hippocampus is an important brain structure involved in memory and navigation of both rats and humans. Neurons in the hippocampus can be “spatially” tuned, meaning they fire in specific physical locations. These spatially tuned cells are referred to as place cells. Collectively, they are thought to provide a map-like representation of the environment around us. If the environment is changed, some place cells can adjust by “remapping”, or altering their firing patterns. There are multiple sub-regions within the hippocampus. During experiments, cells were recorded simultaneously from the dorsal and ventral hippocampus of rats running on a track for food …

Amygdala And Neocortical Structural Volume Analysis In The Shank3b Mutant Mouse Model Of Autism Spectrum Disorder, Preet Sawhney

Honors Scholar Theses

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is characterized by abnormal social behavior, deficits in communication, and motor stereotypy. The SHANK3 gene, responsible for the generation of a scaffolding protein that is integral for the development of synapses, has been identified as one of the primary candidate genes implicated in the disorder. Shank3B is the rodent homolog for this gene. Research has shown that when this gene is disrupted in rodent models (e.g., via knock-out (KO)), ASD-like behaviors result. These include deficits in social interaction, increased anxiety, and repetitive self-grooming. The current study aimed to identify a physiological …

The Role Of Dopamine In Decision Making Processes In Drosophila Melanogaster, Michelle C. Bowers

Undergraduate Honors Theses

Understanding the neural processes that mediate decision making is a relatively new field of investigation in the scientific community. With the ultimate goal of understanding how humans decide between one path and another, simpler models such as Drosophila Melanogaster, the common fruit fly, are often utilized as a way of determining the neural circuits involved in these decision-making processes. One of the most important decisions flies make is the decision of where to lay their eggs (oviposit). Choosing the proper substrate upon which to lay eggs is a crucial decision that can ultimately impact their fecundity. This paper investigates the …

The Effects Of The Atypical Dopamine Uptake Inhibitor Ce-158 On Extracellular Dopamine In The Nucleus Accumbens, Julia Neri

Honors Scholar Theses

Major Depressive Disorder (MDD) is characterized by symptoms such as cognitive dysfunctions, inflammatory changes, and motivational symptoms such as amotivation, fatigue, and anergia. While depressed people are commonly treated by traditional antidepressants such as serotonin reuptake inhibitors (SSRIs), previous studies have reported that SSRI medications do not treat fatigue and anergia symptoms well, and in some cases, can even worsen those symptoms. Subjects treated with dopamine (DA) uptake inhibitors, on the other hand, have been less likely to report symptoms of anergia and fatigue compared to those treated with SSRIs. Common DA uptake inhibitors such as methylphenidate and amphetamines, however, …

The Effects Of Music Arousal Level And Tempo On Card Game Players’ Risk-Taking And Eeg Mental State Among Introverts And Extroverts, Hao Yi Ho

Student Works (2020-2029)

This is an experimental quantitative study which examined the effects of music arousal level and tempo on card game players’ risk-taking and EEG mental state among introverts and extroverts. A total of 20 male participants (through selection of 10 introverts and 10 extroverts) aged between 18 – 29 voluntarily participated by playing the card game In-Between. All participants put on the NeuroSky® MindWaveTM Mobile EEG device and played the game while being exposed to various music conditions. The conditions were no-music (control) condition, and a set of both high-arousal (hereafter HA) and low-arousal (hereafter LA) music manipulated to three different …

Argumentative Synthesis Essay On Enhanced Interrogation Techniques, Gwendolyn D. Wheatley

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This essay discusses enhanced interrogation techniques. For reference, enhanced interrogation techniques are interrogation techniques that involve “physically coercive interventions” (Duke & Puyvelde, 2017). The U.S. government supported these techniques after the attacks on September 11, 2001. This essay argues that enhanced interrogation techniques should not be used in interrogations because they are unethical, ineffective, and negatively impact the mental health of the interrogators using these techniques. Additionally, the essay references articles on the varied viewpoints as well as explains information on these interrogation techniques. Also, the essay argues that enhanced interrogation techniques encourage people to be cruel and inhumane. Moreover, …

Sedative And Neurotoxic Properties Of Brexanolone Compared To Midazolam In The Developing Rodent Brain, Jacob Huffman

Dissertations

The developing brain is susceptible to extensive neurotoxicity following exposure to sedative/anesthetic drugs (SADs). Every year hundreds of thousands of children around the world are exposed to SADs with no viable non-neurotoxic agents approved for clinical use. Allopregnanolone (AlloP) has well-established sedative effects in adults and neonates. AlloP and many SADs produce sedation/anesthesia through allosteric modulation of GABA_A receptors, which is one of two principal mechanisms behind SAD-induced neurotoxicity. Evidence suggests AlloP has the unique capacity to regulate key apoptotic factors in adults and is widely involved with critical stages of neurodevelopment, indicating this neurosteroid might serve as a …

Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell

Theses

Kappa opioid receptors are colocalized with dopamine receptors and are frequently associated with depression, anxiety, stress, and drug use and abuse. KOR antagonism has widely been considered anti-depressive and anxiolytic in animal models while agonism is pro-depressive and anxiogenic. However, recent findings suggest that SalvA, a natural kappa agonist derived from a plant in the mint family, can reduce depressive- and anxiety-like behavior in rats. The current study investigated the effects of chronic mild stress on behavior, attenuation by SalvA, and sex differences. 52 Long-Evans rats, 26 males and 26 females, were exposed to six weeks of CMS. Animals received …

161— The Effects Of Environment On The Development Of Cocaine-Seeking, Gavin Vaughan, Akane Ichiki, Shreyya Malik, Allison R. Bechard

GREAT Day Posters

Cocaine addiction is a major individual and societal issue. This study aimed to investigate the environmental and social factors that influence the development of cocaine addiction. Mice were reared in either standard housing or enriched housing. Cocaine preference was measured using the Conditioned Place Preference paradigm, in which subjects are conditioned to associate an injection of cocaine (20mg/kg. I.P.) with a particular side of a 3 chambered arena. Subjects reared in enriched environments displayed increased preference for cocaine in cue primed tests. All subjects displayed cocaine preference in cocaine primed tests. This may be attributed to the enhanced memory that …

130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano

GREAT Day Posters

Now a popular fad diet, the ketogenic diet (KD) is a high-fat, low-carb diet that for decades has been used for treatment of intractable epilepsy. Recent therapeutic applications of KD in animal models include treatment of dementia, obsessive-compulsive disorder, and autism. These disorders are associated with stereotypic behaviors (repetitive, invariant behaviors with no apparent function) that are life-impairing and stigmatizing. However, little is known about their underlying mechanisms and no effective pharmacological treatments are available. Here, we present a novel application of KD to reduce stereotypic behavior in an inbred strain of mice (FVBN/J) that displays a prominent repetitive circling …

159— The Effects Of Trauma On The Response To Cocaine, Gavin Vaughan, Melissa Herman, Katie Kompanijec, Maren Hogan, Annaclaire Modico, Keara Mullin, Allison R. Bechard Ph.D.

GREAT Day Posters

Exposure to adverse events is a risk factor for substance use disorder. We modeled this in an inbred strain of mice by exposing adult males to a predator odor (a synthetic fox pheromone, TMT) and then assessing 1. Cocaine-induced locomotion, and 2. Conditioned place preference (CPP) of cocaine. TMT was an effective stressor as indicated by freezing behavior, an absence of movement that is an instinctive fear response in mice. Interestingly, in a 1-hour baseline locomotor test, TMT-exposed (TMT+) mice were more active than non-exposed (TMT-) mice. In addition, following a cocaine (10 mg/kg) injection (i.p.) TMT+ mice showed a …

The Influence Of Hsv-1 Infection On Circadian Rhythms And Behavior In Mice, Lauren Evert, Kevin Catalfano, Victoria Gardner, Anna Lunderberg

19th Annual Celebration of Undergraduate Research and Creative Activity (2020)

Herpes simplex virus 1 (HSV-1) infection is a lifelong viral infection that affects approximately half of the human population (McQuillan et al., 2018), yet little is known about its neurological effects. There is correlational evidence that infection with HSV-1 can induce cognitive decline and increased anxiety behaviors (Harris & Harris, 2015; Steel & Eslick, 2015; Tarter, Simanek, Dowd, & Aiello, 2014). In addition, HSV-1 may be associated with disruptions to circadian rhythms because HSV-1 is associated with chronic fatigue syndrome (Bond & Dinan, 2006), the time of HSV-1 infection impacts the viral replication (Edgar, 2016), and HSV impacts CLOCK machinery …

Pornography: Adolescent Brain Development & Addiction, William K. Canady

National Youth Advocacy & Resilience Conference

This presentation will explain the historical development of pornography. It will highlight three segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention.

Do Social Networks Impact Perceived Loneliness In Caregivers To Older Adults With Chronic Conditions?, Janelle N. Beadle, Hayley Fouche, Angela Gifford

UNO Student Research and Creative Activity Fair

The abstract is not published at this time to protect intellectual property.

Mapping The Spatial And Temporal Dynamics Of Visual Percepts Elicited By A Non-Invasive Brain Stimulation Technique, Kelly Webster

Dissertations, Theses, and Capstone Projects

While many of us rely on vision to interact with and experience the world, for people with damage or disease to the eye or visual cortex, experience through this modality is extremely limited. Brain and retinal stimulation devices show exciting promise for restoring vision, but little is understood about where and when vision percepts can be induced through stimulation. Using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS), we characterized the spatial and temporal dynamics of perception induced through brain stimulation. In the first set of experiments, we explore the importance of higher visual and non-visual areas vs. …

Experience-Dependent Changes In Nucleus Accumbens Activity Predict Cued Approach Learning: Contribution Of Nmda Receptors, Mercedes Vega Villar

Dissertations, Theses, and Capstone Projects

Animals learn associations between environmental cues and the natural rewards they predict (e.g., food, water, sex). As a result, reward-predictive cues come to trigger vigorous reward-seeking responses. Many neurons in the nucleus accumbens (NAc) become excited upon presentation of an already-learned reward-predictive cue. These NAc responses encode the motivational value of the cue and are necessary for the expression of the subsequent approach behavior. However, the precise temporal relationship between the emergence of cue-evoked excitations in the NAc and the acquisition of cued approach behavior remains unknown. In Experiment 1, NAc activity was recorded as rats learned to approach a …