Neuroscience and Neurobiology Commons^™

Weighted Family History Density Of Substance Use: Influence On Participant Substance Use Onset, Escalation, And Duration, Carleigh A. Litteral

Theses and Dissertations--Psychology

Substance use disorders impose a staggering toll on the United States (U.S.), straining healthcare systems, destabilizing communities, and profoundly impacting both individuals and families. Approximately one in six Americans aged 12 and older had a past-year substance use disorder in 2022 (Key Substance Use, 2022), and nearly one-third of adults experience a substance use disorder in their lifetime (Wu, 2010), contributing to an economic burden exceeding $400 billion annually (National Drug Threat Assessment, 2011). Family history of substance use disorders is a key predictor of vulnerability, with individuals who have affected relatives being 2–8 times more …

Exploring The Effects Of Transcranial Direct Current Stimulation Of The Right Inferior Frontal Gyrus On Inhibitory Control In Posttraumatic Stress Disorder, Colton Rippey

Theses and Dissertations--Psychology

Background: The right inferior frontal gyrus (rIFG) is implicated in stop signal reaction time (SSRT) performance – a common measure of inhibitory control – and emotional expression and control. Individuals with posttraumatic stress disorder (PTSD) exhibit poorer stop SSRT performance, which is associated with rIFG hypoactivity. Neuromodulation of the rIFG with transcranial direct current stimulation (tDCS) can significantly improve inhibitory control and reduce fearful responding to threatening stimuli. Research has yet to test the effects of multifocal tDCS targeting the rIFG on inhibitory control or emotional reactivity in individuals with PTSD.

Methods: The current study aims to examine the impact …

Précis Of The Edge Of Sentience: Risk And Precaution In Humans, Other Animals, And Ai, Jonathan Birch

Animal Sentience

We often face grave practical decisions that seem to hinge on whether a system is sentient. This family of cases includes invertebrate animals, people who are unresponsive after brain injury, fetuses, neural organoids, and now AI technologies. We must decide what to do despite ongoing disagreement about the nature of sentience. In our state of uncertainty, we should pragmatically transform the question from “Is it sentient?” to “Is it a sentience candidate, an investigation priority, or neither?”. When a system is a sentience candidate, it is negligent to fail to consider precautions. We should instead evaluate precautions for their proportionality …

Die Wirkliche Gefahr Liegt In Der Erosion Der Autonomie: Ein E-Mail-Interview Über Kognitive Freiheit Und Die Problematische Nutzung Neuronaler Daten, Nita Farahany, James Kennaway, Bernd Bösel

Faculty Scholarship

In this interview, James Kennaway and Bernd Bösel talk to Nita Farahany about significant themes related to the idea of mind control, as discussed in her book "The Battle for Your Brain" (2023). The book outlines the risks that neurotechnology poses to "cognitive freedom". EEG and EMG data are increasingly used in consumer products, raising concerns about potential misuse. Companies and governments could exploit cognitive biometric data for manipulation or control. Farahany calls for clear legal protections and highlights differences between U.S. and European regulations. She warns of neurotechnological warfare and advocates for global bans. While full mind control remains …

Can Animal Consciousness Be Resolved Scientifically?, Yoram Gutfreund

Animal Sentience

Carolyn Ristau's biography of Donald Griffin is a comprehensive work that sheds light on a seminal chapter in the history of ethology—the ambitious attempt to establish a research field dedicated to animal consciousness. Although Donald Griffin's endeavor ultimately fell short of its revolutionary goals, it catalyzed significant progress in understanding evolution and mechanisms of animal cognition.

How Do Anxiety, Stress, Impulsiveness, And Sleep Quality Affect Memory, Hodavia Tshiya Kaseya

Online Theses and Dissertations

Memory is a critical cognitive function that enables individuals to retain, recall, and apply knowledge across various contexts. Different memory systems, including working memory and long-term memory, collaborate to process and store information. Factors such as stress, sleep disturbances, anxiety, and impulsiveness can impact memory encoding and retrieval, especially in college students, whose academic success depends heavily on memory performance. This study examined the relationship between these everyday factors and memory performance by analyzing brain activity during memory encoding using Electroencephalography (EEG) and the Difference due to memory (DM) event-related potential (ERP) effect, to understand how stress, sleep, anxiety, and …

Conceptual Curiosity: Sense(Un)Making, Rebekah L. Cowell

Proceedings from the Document Academy

Across disciplines, sensemaking is a theoretical and methodological research program, over forty years in development, that has been treated as a framework for understanding how humans behaviorally respond to external information sources and interpret to construct and actualize actionable outcomes; however, sensemaking is an interlinking process that does not operate in singularity–behaviorally or actionably–it is neurobiological (autonomous drive), cognitive (perceptual and predictive), and psychological (congruency in meaning).

This paper enlarges the conceptual framework for studying sensemaking and redefines it by addressing what sensemaking is, does, and needs. At the core of this conversation is addressing the absence of knowledge and …

Psychological Distress Among Family Caregivers Of Persons With Alzheimer’S Disease And Related Dementias In Uganda, Martha Sajatovic

Faculty Scholarship

Background: Alzheimer's disease and related dementias (ADRD) present growing global health challenges, especially in aging populations, such as Uganda. In Uganda, familial caregiving, predominantly undertaken by female relatives, is the primary form of support provided to patients with ADRD. Cultural stigma around dementia and limited access to support services amplify caregivers' challenges. This study examined psychological distress, depression, and quality of life (QoL) among family caregivers of patients with ADRD in Wakiso District, Uganda. Methods: This cross-sectional study involved 90 caregivers from three sub-counties in Wakiso, selected through purposive sampling to capture diverse experiences. Participants included caregivers aged 18 years …

Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna

Electronic Theses, Projects, and Dissertations

In Parkinson’s Disease (PD), research has shifted to investigate how biomarkers commonly seen in Alzheimer’s Disease (AD), such as amyloid beta (AB), may be associated with cognitive functioning in PD. AB is considered a reliable biomarker for AD pathology, however in PD there is a lacking biomarker that can accurately reflect severity of cognitive impairment. AD research has shown an association between low AB and cognitive decline, but the data in PD has mixed results. Most studies that analyze cognitive decline and biomarkers do not use a cutoff level and the few that do have a threshold vary greatly in …

Covid 19 Is A Hoax, Vidushi Sharma '28

Best First-Year Seminar Writing

When COVID-19 first swept across the globe, it brought more than just a viral contagion—it sparked an epidemic of misinformation. Among the various conspiracy theories, one stands out for its audacity: the claim that COVID-19 does not exist. This theory undermines public health efforts, sows mistrust, and complicates crisis management. But why do people believe it, and what makes such narratives so compelling? More importantly, how can we combat this damaging misinformation? This essay explores the origins of the "COVID-19 doesn't exist" conspiracy, examines its three main iterations—denial of the virus’s existence, claims of government overreach, and accusations of corporate …

Medial Prefrontal Cortex To Nucleus Reuniens Circuit Is Critical For Performance In An Operant Delayed Nonmatch To Position Task, Evan J Ciacciarelli, Scott D Dunn, Taqdees Gohar, T Joseph Sloand, Mark Niedringhaus, Elizabeth A West

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. The prefrontal cortex and its connections with thalamic subregions are thought to mediate specific aspects of working memory, including engaging with the hippocampus to mediate memory retrieval. We used an operant delayed-non match to position task, which does not require the hippocampus, to determine roles of the rodent medial prefrontal cortex (mPFC), the nucleus reuniens thalamic region (RE), and their connection. We found that transient inactivation of the mPFC and RE using the GABA-A agonist muscimol led to a …

The Effects Of Divides Attention On Long-Term Memory For Natualistic Stimuli, Gaia Steinberg, Jackson S. Pelzner, Rhiannon N. Soriano Smith, Colleen M. Parks

Undergraduate Research Symposium Posters

The ability to identify previously experienced events is a fundamental aspect of memory. This study investigates recognition memory using naturalistic stimuli, specifically news headlines, to explore both controlled (recollection) and automatic (familiarity) memory processes. Most recognition memory experiments rely on simplistic stimuli like words or pictures, but we aim to extend these theories by using more complex, naturalistic materials (news headlines). Participants completed recognition tasks with both headlines and pictures to establish baseline differences between these stimuli types. The order of presentation between stimulus types was randomized between pictures or headlines first. They were assigned to either full or divided …

Glial-Specific Genes Are Strongly Associated With Alzheimer's Disease By Gene-Based Polygenic Risk Score Analysis, Jennifer Zheng, Faria Tavacoli, Tyrell Pratt, Alice Lee, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Methods: Gene-based PRSs were constructed in AD cases and controls within each gene of the glial cells, according to the GWAS summary statistics of European ancestry. In detail, gene-based PRSs were first calculated for each glial cell type-specific gene for AD cases and controls in the discovery dataset (ADc1234ADA) using PRSet software. A meta-analysis with a fixed model was performed when the signal in both datasets was in the same direction. Bonferroni corrections for multiple testing (at α = .05) were used to determine significance within each of the three glial groups. Forest plots were used to visualize the results …

Evaluating Human Plasma Biomakers For Alzheimer's Disease; Phosphorylated-Tau 217, Phosphorylated-Tau 181, And Glial Fibrillary Acidic Protein, Mason Jonah, Mayarae N. Mugosa, Bella Hou, Emma-Nikole Krilchev, Zhengshi Yang, Dietmar Cordes, Aaron Ritter, Jefferson W. Kinney

Undergraduate Research Symposium Posters

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that is primarily identifiable by amyloid-beta (Aβ) neuronal plaques, neurofibrillary tangles (NFT) that form as aggregates of hyperphosphorylated tau (ptau) proteins clump together, and the presence of neuroinflammation; all of which are otherwise known as the hallmarks of AD pathology. Recent emerging research has discovered striking similarities between AD and diabetes mellitus pathology, illustrating how insulin deficiency and insulin resistance–both of which result in the chronic hyperglycemic state seen in the diabetic–are involved in an increase in the phosphorylation of tau. This leads to and intensifies the formation of intracellular NFTs serving …

Exploring Modality Differences In Recognition Memory: Repetition Effects On Recollection And Familiarity, Ivanesa Velikova, Kevin Mohawk, Colleen Parks

Undergraduate Research Symposium Posters

Research has shown that memory for visual objects tends to be superior compared to memory for auditory objects. The present study aimed to investigate the underlying mechanisms of why recognition memory tends to be better for visual information. Recognition memory relies on two processes, recollection and familiarity. Recollection involves retrieving contextual details of a memory while familiarity is simply a feeling that something has been encountered before. We investigated recollection and familiarity in the two modalities by having participants lean a list of auditory objects (e.g., dog barking) and visual objects (e.g., picture of a lion) under full attention (FA) …

The Effect Of Encoding Strategies On Recognition Memory, Camila Schettini, Cole Kaneshiro, Kevin Mohawk, Colleen Parks

Undergraduate Research Symposium Posters

Successful memory decisions require distinguishing between true and false memories. VariouS strategies can be used to avoid false memories such as the Recall-To-Reject (R-R) strategy and the Distinctiveness Heuristic (DH). R-R involves rejecting false information by recalling correct information (I know this person is not Bob, because Bob has brown hair); while DH involves the rejection of false information due to failure to recollect expected information (I know I never met this person because I would remember if I had). The purpose of this study is to examine how these strategies affect recognition memory. In the present study participants were …

Comparing Forgetting Rates Between Item And Relational Memories, Lex De Asis, Rhiannon N. Soriano Smith, Colleen M. Parks

Undergraduate Research Symposium Posters

Forgetting is an everyday occurrence where an idea that could be recalled successfully is no longer able to be retrieved (Tulving, 1974). Multiple theories suggest how forgetting occurs, such as the decay theory, which suggests that memories are gradually forgotten over time, and the interference theory, in which forgetting occurs because of competing information. Additionally, there are two newer theories which both predict that item representations should be forgotten because of interference and mnemonic discrimination should be forgotten due to decay: the memory system-dependent forgetting hypothesis (Hardt, Nader, & Nadel, 2013), and the representation theory of forgetting (Sadeh et al., …

Examining Emotion And Ease Of Recall For Life Story Memories In Young Adults, Roxanna E. Chavez, Erin L. Murphy, David E. Copeland

Undergraduate Research Symposium Posters

Life stories are narratives that use autobiographical memories to shape personal identity. This study investigated how emotional valence and ease of recall may change over time. Participants were asked to recall ten life story memories in two interviews held three weeks apart. Participants provided ratings of emotional valence and ease of recall for each memory. A significant difference was found in emotional valence between Session 1 (M = 3.159, SD = .772) and Session 2 (M = 2.905, SD = .788), t(68) = 2.734, p < .01, with Session 1 memories rated as significantly more negative (M = 1.812, SD = 1.427) than those in Session 2 (M = 1.275, SD = 1.316), t(68) = 3.232, p < .01. Furthermore, negative memories were more frequent in the last five Session 1 memories (M = 0.986, SD = 0.866) than in all of Session 2 memories (First Five: M = 0.652, SD = .783; Last Five: M = 0.623, SD = .892), F(3, 204) = 3.663, p < .05. For ease of recall, the first five memories in both sessions (Session 1: M = 5.684, SD = 0.806; Session 2: M = 5.612, SD = 0.963) were significantly easier to recall than the last five in both sessions (Session 1: M = .214, SD = 1.128; Session 2: M = 5.136, SD = 1.080), F(2.498, 169.864) = 7.369, p < .001. Overall, these findings suggest participants recalled more accessible memories first, with negative memories being harder to retrieve as sessions progressed.

Investigating The Impact Of Psychological Interventions On Autoimmune Disease Progression In Women, Nicole Datastanyan

Undergraduate Research Symposium Posters

Autoimmune disease arises when an individual's immune system mistakenly attacks and damages the body’s tissues. Autoimmune disease disproportionately affects women, with eighty percent of diagnosed patients being female. This research proposal aims to explore the relationship between psychological factors (e.g., stress, anxiety, depression) and the progression of autoimmune diseases. This poster will propose a detailed study to assess whether reducing psychological distress through cognitive behavioral therapy (CBT) can slow disease progression. Cognitive behavioral therapy is a form of talk therapy to relieve symptoms of mental health conditions such as depression, anxiety, stress, or grief. Two hundred female patients diagnosed with …

Pathway-Based Polygenic Risk Score Analysis Of Brain Glial Indicates Cell-Type-Specific Roles In Alzheimer's Disease, Tyrell Pratt, Alice Lee, Jennifer Zheng, Faria Tavacoli, Hayley Ho, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and extensive brain pathology, including amyloid plaques, neurofibrillary tangles, and neuroinflammation. This study aims to identify any glial cell type-specific pathways associated with AD.

Methods: We first investigated the correlation between AD and the genetic risk of glia-specific pathways using pathway-based polygenic risk score (PRS) with PRSet software in the discovery data (ADc1234ADA) adjusted by the top two principal components (PC1, PC2) (Model 1), followed by additional adjustment with sex, age, and APOE ε4 count in Model 2. Further PRSet analyses were replicated in independent data …

Inter-Rater Reliablility Of Sharp Wave Ripple Detection In Recently Trained Experts, Orlando Montiel, Gage Pompa, Yader Gomez, Talha Soluoko

Undergraduate Research Symposium Posters

Sharp wave ripples (SWR) are a brain phenomenon that originate in the hippocampus, a region crucial for memory and learning. These events occur during periods of rest or slow-wave sleep and are characterized by fast oscillatory bursts (150-250Hz) and are thought to be important for the brain to consolidate memory. SWR are believed to facilitate the transfer of information from the hippocampus to the cortex, strengthening synaptic connections & enabling long-term memory storage. Accurate detection & assessment of SWRs is essential for advancing how the brain processes and stores information.

This study examines the accuracy/consistency of SWR image selection and …

Association Between Polygenic Scores For Brain Structure And Alzheimer's Disease, Eunjae Lee, Faria Tavacoli, Tingwei Liu, Brittany Diaz Ruiz, Hayley Ho, Alice Lee, Jingchun Chen

Undergraduate Research Symposium Posters

Alzheimer’s disease (AD) is a progressive neurodegenerative condition and the most common type of dementia. Research has shown that volumetric changes in subcortical brain structures, which make up roughly 25% of the brain's total volume and affect many physiological functions. This research project aims to investigate the genetic association between brain structures and AD. GWAS data of eight different brain structures (ICV, accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus) were used to create polygenic scores (PGSs) in a discovery (cases/controls = 2,651/2,768) and replication dataset (cases/controls = 553/644). We utilized PRSice-2 software to generate PGSs and assess genetic correlations …

An Investigation Of Frequency-Domain Pruning Algorithms For Accelerating Human Activity Recognition Tasks Based On Sensor Data, Jian Su, Haijian Shao, Xing Deng, Yingtao Jiang

Electrical & Computer Engineering Faculty Research

The rapidly advancing Convolutional Neural Networks (CNNs) have brought about a paradigm shift in various computer vision tasks, while also garnering increasing interest and application in sensor-based Human Activity Recognition (HAR) efforts. However, the significant computational demands and memory requirements hinder the practical deployment of deep networks in resource-constrained systems. This paper introduces a novel network pruning method based on the energy spectral density of data in the frequency domain, which reduces the model’s depth and accelerates activity inference. Unlike traditional pruning methods that focus on the spatial domain and the importance of filters, this method converts sensor data, such …

To Be Conscious Or Not To Be, Bjørn Grinde

Animal Sentience

Carolyn Ristau has done a fine job summarizing the work and life of the zoologist Donald Griffin. Most scientists now accept the existence of animal sentience, but identifying which species possess consciousness remains controversial. Griffin defined consciousness as "the subjective state of feeling or thinking about objects and events.” Nonconscious processes are faster and more energy-efficient, however, and often drive behavior. Consciousness probably evolved for complex decision-making, shaped by evolutionary continuity, with feelings as a common currency for evaluating outcomes. Its survival advantage may be limited, and its presence across species varies depending on evolutionary trajectories.

Structural Projections To The Nucleus Accumbens Link To Impulsive Components Of Human Risk Preference, Loreen Tisdall, Kelly H. Macniven, Josiah Leong, Renato Frey, Jörg Rieskamp, Ralph Hertwig, Brian Knutson, Rui Mata

Psychological Science Faculty Publications and Presentations

Functional responses in the Nucleus Accumbens (NAcc) to risk- and reward-related cues can predict real-life risk-taking behavior. Since NAcc activity depends on neurotransmission from connected brain regions, projections to the NAcc may also predict risk preference. To quantify risk preference, we employed latent variables previously derived in a comprehensive, independent study examining the psychometric structure of risk preference, which yielded a general risk preference factor as well as several specific factors, including a factor capturing impulsivity. Informed by previous work, we preregistered a set of hypotheses concerning the association between different risk preference factors and fractional anisotropy (or FA, which …

Neural Correlates Of Socially Rewarding Memories In Posttraumatic Stress Disorder, Kyle P. Blidy

MUSC Theses and Dissertations

Significance. Memory disturbances for emotional content are central to PTSD, yet most research focuses on trauma memories. Recent evidence suggests that enhancing access to positive memories could improve mood, affect regulation, self-esteem, and integration of trauma memories. However, the neurocognitive mechanisms underlying positive memory encoding in PTSD are poorly understood. No study has examined memory for positive social items in PTSD, which is important because PTSD entails social withdrawal and reduced accessibility to positive memory. Additionally, positive memories embedded in a social context have enhanced subjective value and strengthening their accessibility may confer greater benefits to wellbeing compared to non-social …

Memory Modulation: Dominance Of Negative Visual Context Over Neutral Verbal Memory, Stas Kozak, Noa Herz, Maya Tocker, Yair Bar-Haim, Nitzan Censor

Department of Neurology Faculty Papers

Neutral memories can be modulated via intentional memory control paradigms such as directed forgetting. In addition, previous studies have shown that neutral visual memories can be modulated indirectly, via remember and forget instructions towards competing verbal memories. Here we show that direct modulation of neutral verbal memory strength is impaired by negative visual context, and that negative visual context is resistant to indirect memory modulation. Participants were directly instructed to intentionally remember or forget newly encoded neutral verbal information. Importantly, this verbal information was interleaved with embedded negative visual context. Results showed that negative visual context eliminated the well-documented effect …

Behavioral And Neural Evidence For Perceptual Inference Of Position, Sharif Saleki

Dartmouth College Ph.D Dissertations

Extensive neuroscientific research has advanced our knowledge of the mechanisms involved in the detection and recognition of visual stimuli. However, to guide flexible behavior in a changing world, the brain must also construct stable and coherent perceptual representations from retinal images that are often ambiguous. To resolve ambiguities and uncertainties, the visual system combines its input with other sources of information such as context and prior knowledge to infer the most likely interpretation of a scene. Thus, perception is inherently an inferential process that goes beyond simple detection or recognition of stimuli. Although inference has been studied in many areas …

Robust And Generalizable Representations In The Hippocampus, Hung-Tu Chen

Dartmouth College Ph.D Dissertations

An intelligent system must balance generalizing across similar experiences with maintaining the distinctiveness of each experience. This thesis explores how the hippocampus manages this balance through its neural representations to support adaptive behavior. In Chapter 1, I provide an overview of key hippocampal phenomena that contribute to this process, including remapping, splitter signal, and replay. In Chapter 2, I challenge the concept of random remapping by showing that it is possible to predict, better than chance, how a given experience will be encoded in the hippocampus across different subjects. This suggests that encoding of related experiences, which was previously thought …

Resting-State Eeg Microstate Features For Major Depressive Disorder Classification, George M. V. Quinn

Dissertations, Theses, and Capstone Projects

Neuroimaging studies have revealed consistent abnormalities in functional connectivity within specific neural networks that may serve as biomarkers for major depressive disorder (MDD). It is important to find inexpensive, non-invasive techniques that target these biomarkers to make diagnosis easier and more objective. EEG microstates are quasi-stable potential topographies that are thought to reflect the quasi-stable network activity of the underlying neural generators. MDD has been shown to alter features of the four canonical EEG microstates (A, B, C, D) with some conflicting results. The most consistent network abnormalities in MDD are found in the anterior default mode network, and this …