Neuroscience and Neurobiology Commons^™

Age Differences In The Frontal Lateralization Of Verbal And Spatial Working Memory Revealed By Pet, Alan Hartley, Patricia A. Reuter-Lorenz, John Jonides, Edward E. Smith, Andrea Miller, Christina Marshuetz, Robert A. Koeppe

Scripps Faculty Publications and Research

Age-related decline in working memory figures prominently in theories of cognitive aging. However, the effects of aging on the neural substrate of working memory are largely unknown. Positron emission tomography (PET) was used to investigate verbal and spatial short-term storage (3 sec) in older and younger adults. Previous investigations with younger subjects performing these same tasks have revealed asymmetries in the lateral organization of verbal and spatial working memory. Using volume of interest (VOI) analyses that specifically compared activation at sites identified with working memory to their homologous twin in the opposite hemisphere, we show pronounced age differences in this …

Mechanism Of Triazolo-Benzodiazepine And Benzodiazepine Action In Anxiety And Depression: Behavioral Studies With Concomitant In Vivo Ca1 Hippocampal Norepinephrine And Serotonin Release Detection In The Behaving Animal, Patricia A. Broderick, Omotola Hope, Pierrot Jeannot

Publications and Research

1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA₁ region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat.

2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection.

3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam …

Transcranial Magnetic Stimulation Of The Prefrontal Cortex Delays Contralateral Endogenous Saccades, Tony Ro, Avishai Henik, Liana Machado, Robert D. Rafal

Publications and Research

The contributions of the superior prefrontal cortex (SPFC) and the superior parietal lobule (SPL) in generating voluntary endogenous and reflexive visually guided saccades were investigated using transcranial magnetic stimulation (TMS). Subjects made choice saccades to the left or right visual field in response to a central arrowhead (endogenous go signal) or a peripheral asterisk (exogenous go signal) that were presented along with a single TMS pulse at varying temporal intervals. TMS over the SPFC increased latencies for saccades made in response to an endogenous go signal toward the contralateral hemifield. No effects were observed when the go signal was exogenous …

Deaf Undergraduate Writing And Cognitive Processes, Elke L. Betz-Schmidt

Undergraduate University Honors Capstones

Literacy among deaf and hard of hearing students has always been low. In the Spring of 1991 the English department at Gallaudet University did an assessment of students' abilities and needs. These results confirmed that the students were not ready to perform at the collegiate level despite eventually graduating with their degrees. Recommendations from the survey, however, do not focus on determining the writing process of the students, or a teaching method focused on composition. Thus, this thesis addresses three questions: does focusing a Deaf undergraduate student's attention on the writing process ane associated thought processes lead students to write …

Interview: Brenda Laurel, Jason Challas

SWITCH

This interview with Brenda Laurel, Virtual Reality (VR) author and thinker, discusses the applications and challenges of VR. Creating an emphatic experience using VR technology is possible, but the challenge lies in designing an environment that models the senses to stimulate emotions. VR enables experiences of different genders, but physiological differences between the sexes exist and are important to understand. However, technology used to create the environment and simulation of physical objects in VR is only in the developmental stage. Laurel believes in the importance of keeping the mind grounded in the physical body, in order to strengthen the appreciation …

Material-Specific Processes In Tactile Short-Term Memory, Christina Anne Meyers

Dissertations and Theses

Studies concerning tactile short-term memory (short-term memory or the sense of touch) have often been contradictory. Some of these studies support the existence of modality-specific tactile memory, a separate, independent storage system for tactile information. Other studies do not support such a system. Further, confusion has arisen regarding the tactile test materials, since many of them use common shapes which are easily labeled verbally. It is hypothesized that information which can be labeled is stored in material-specific verbal memory in the left hemisphere, while patterned or spatial information is stored in material-specific nonverbal memory in the right hemisphere.

This paper …

A Comparison Of Ecs And Drug Induced State-Dependent Learning, Mayse F. John

All Master's Theses

The purpose of the present experiment is twofold: (a) to determine if FS and ECS or just ECS can be used as an agent to produce "dissociated" learning in a multi-trial procedure, and (b) if shown, to determine the effectiveness of these agents relative to three different dosages of sodium pentobarbital preselected to produce no, moderate, and complete dissociation.