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Full-Text Articles in Virology
Production Of Antibodies For Specific Detection Of Dengue Virus-2 By Surface Enhanced Raman Spectroscopy, E. Ashley Thompson
Production Of Antibodies For Specific Detection Of Dengue Virus-2 By Surface Enhanced Raman Spectroscopy, E. Ashley Thompson
Honors Theses
Dengue Virus (DENV) is a flavivirus spread by mosquitoes that are endemic in tropic and subtropic climates. It is the causative pathogen of Dengue Fever, Dengue Hemorrhagic Fever, and Dengue Shock Syndrome. Besides mosquito transmission, DENV can also be transmitted through blood transfusion. Due to the high expense and expertise needed to run tests like ELISA and Polymerase Chain Reaction (PCR) based-assays for DENV detection, a rapid, sensitive and cost effective gold nanoparticles mediated surface-enhanced Raman spectroscopy (SERS) assay has been developed as an alternative assay to detect DENV. In this project, I successfully produced a monoclonal antibody that specifically …
Elucidating The Role Of Interleukin-17a In West Nile Virus Infection, Dhiraj Acharya
Elucidating The Role Of Interleukin-17a In West Nile Virus Infection, Dhiraj Acharya
Dissertations
West Nile virus (WNV) is a neurotropic flavivirus of significant public health importance for which no therapeutics and vaccine are currently available. Interleukin-17A (IL-17A) is an inflammatory cytokine that regulates diverse immune functions, while its role is unclear in host’s immune response to WNV. Furthermore, CD8+ T cells are crucial components of immunity and play a vital role in recovery from WNV infection. Here, we report a previously unrecognized function of IL-17A in regulating CD8+ T cell cytotoxicity. We show that WNV induces the expression of IL-17A in both mouse splenocytes and human peripheral blood mononuclear cells cultured …