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Full-Text Articles in Pathogenic Microbiology
Calling In Sick: Impacts Of Fever On Intra-Urban Human Mobility, T. Alex Perkins, Valerie A. Paz-Soldan, Steven T. Stoddard, Amy C. Morrison, Brett M. Forshey, Kanya C. Long, Eric S. Halsey, Tadeusz J. Kochel, John P. Elder, Uriel Kitron, Thomas W. Scott, Gonzalo M. Vazquez-Prokopec
Calling In Sick: Impacts Of Fever On Intra-Urban Human Mobility, T. Alex Perkins, Valerie A. Paz-Soldan, Steven T. Stoddard, Amy C. Morrison, Brett M. Forshey, Kanya C. Long, Eric S. Halsey, Tadeusz J. Kochel, John P. Elder, Uriel Kitron, Thomas W. Scott, Gonzalo M. Vazquez-Prokopec
Faculty Publications
© 2016 The Author(s) Published by the Royal Society. All rights reserved. Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two groups of febrile individuals (dengue-positive and dengue-negative) with an afebrile control group. A …
Anaplasma Marginale Actively Modulates Vacuolar Maturation During Intracellular Infection Of Its Tick Vector, Dermacentor Andersoni, Foregivemore Magunda, Chelsea Wright Thompson, David A. Schneider, Susan M. Noh
Anaplasma Marginale Actively Modulates Vacuolar Maturation During Intracellular Infection Of Its Tick Vector, Dermacentor Andersoni, Foregivemore Magunda, Chelsea Wright Thompson, David A. Schneider, Susan M. Noh
Biological Sciences Faculty Publications
ABSTRACT Tick-borne transmission of bacterial pathogens in the order Rickettsiales is responsible for diverse infectious diseases, many of them severe, in humans and animals. Transmission dynamics differ among these pathogens and are reflected in the pathogen-vector interaction. Anaplasma marginale has been shown to establish and maintain infectivity within Dermacentor spp. for weeks to months while escaping the complex network of vacuolar peptidases that are responsible for digestion ofthe tick blood meal. How this prolonged maintenance of infectivity in a potentially hostile environment is achieved has been unknown. Using the natural vector Dermacentor andersoni, we demonstrated that A. marginale …