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Articles 1 - 5 of 5
Full-Text Articles in Pathogenic Microbiology
Calling In Sick: Impacts Of Fever On Intra-Urban Human Mobility, T. Alex Perkins, Valerie A. Paz-Soldan, Steven T. Stoddard, Amy C. Morrison, Brett M. Forshey, Kanya C. Long, Eric S. Halsey, Tadeusz J. Kochel, John P. Elder, Uriel Kitron, Thomas W. Scott, Gonzalo M. Vazquez-Prokopec
Calling In Sick: Impacts Of Fever On Intra-Urban Human Mobility, T. Alex Perkins, Valerie A. Paz-Soldan, Steven T. Stoddard, Amy C. Morrison, Brett M. Forshey, Kanya C. Long, Eric S. Halsey, Tadeusz J. Kochel, John P. Elder, Uriel Kitron, Thomas W. Scott, Gonzalo M. Vazquez-Prokopec
Faculty Publications
© 2016 The Author(s) Published by the Royal Society. All rights reserved. Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two groups of febrile individuals (dengue-positive and dengue-negative) with an afebrile control group. A …
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Dennis J. Baumgardner, MD
In introducing the infectious disease focus for this edition of the Journal of Patient-Centered Research and Reviews, the author describes the unsolved mysteries surrounding the dimorphic fungus Blastomyces and the related pathogenesis of pulmonary blastomycosis.
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
In introducing the infectious disease focus for this edition of the Journal of Patient-Centered Research and Reviews, the author describes the unsolved mysteries surrounding the dimorphic fungus Blastomyces and the related pathogenesis of pulmonary blastomycosis.
Role Of The Exopolysaccharide Alginate In Adherence To And Inflammation Of Pulmonary Epithelial Cells, Brian E. Crossley
Role Of The Exopolysaccharide Alginate In Adherence To And Inflammation Of Pulmonary Epithelial Cells, Brian E. Crossley
Theses and Dissertations
Pseudomonas aeruginosa (PA) infections in Cystic Fibrosis (CF) patients are not easily cleared due to the conversion from a nonmucoid to a mucoid phenotype. Alginate is an acetylated exopolysaccharide produced by mucoid PA that is responsible for increased resistance to antibiotics, host phagocytic killing, and propagating biofilm formation. Understanding the interaction between PA and host cells is critical to understanding chronic infection and inflammation in CF. In order to investigate this, we used A549 pulmonary epithelial cells and murine alveolar macrophages (MH-S) to examine host response to nonmucoid versus mucoid PA infection. Adhesion assays in A549 pulmonary epithelial cells revealed …
Anaplasma Marginale Actively Modulates Vacuolar Maturation During Intracellular Infection Of Its Tick Vector, Dermacentor Andersoni, Foregivemore Magunda, Chelsea Wright Thompson, David A. Schneider, Susan M. Noh
Anaplasma Marginale Actively Modulates Vacuolar Maturation During Intracellular Infection Of Its Tick Vector, Dermacentor Andersoni, Foregivemore Magunda, Chelsea Wright Thompson, David A. Schneider, Susan M. Noh
Biological Sciences Faculty Publications
ABSTRACT Tick-borne transmission of bacterial pathogens in the order Rickettsiales is responsible for diverse infectious diseases, many of them severe, in humans and animals. Transmission dynamics differ among these pathogens and are reflected in the pathogen-vector interaction. Anaplasma marginale has been shown to establish and maintain infectivity within Dermacentor spp. for weeks to months while escaping the complex network of vacuolar peptidases that are responsible for digestion ofthe tick blood meal. How this prolonged maintenance of infectivity in a potentially hostile environment is achieved has been unknown. Using the natural vector Dermacentor andersoni, we demonstrated that A. marginale …