Other Microbiology Commons^™

Leptin Protects Dendritic Cells From Chemically-Induced Cell Death, Yadira Arellano^, Jeffrey Charles Sivils, Kristine Marie Garza*

COURI Symposium Abstracts, Spring 2011

Leptin is a pleiotropic adipokine that exerts its physiological effects by binding to its receptor, which is expressed in many immune cells including T cells, macrophages, and dendritic cells. Multidrug resistance-associated protein (MRP) is a transmembrane transporter commonly associated with cancer cells conferring resistance to chemotherapy. The purpose of this study is to determine if leptin supersedes the cytotoxic death signal in dendritic cells. We further hypothesize that the mechanism underlying leptin protection is a result of over expression of MRPs. To address this question, we examined the effect of leptin on monocytes treated with cytotoxic drugs in vitro.  Bone …

Pattern Recognition In Cytopathology For Papanicolaou Screening, Jonathan Blackledge, Dmitriy Dubovitskiy

Conference papers

A unique space oriented filer is presented in order to detect and isolate the cell of a nucleus for applications in cytopathology. A classification method for nuclei is then considered based on the application of a set of features which includes certain fractal parameters. Segmentation algorithms are considered in which a self-adjustable sharpening filter is designed to enhance object location. Although the methods discussed and the algorithms developed have a range of applications, in this work we focus the engineering of a system for automating a Papanicolaou screening test using standard optical images

Analysis Of Gene Expression During Embryonic Development In Mulberry Silkworm Bombyx Mori, Amit Singh, K. P. Gopinathan

Biology Faculty Publications

We have developed a method for dechorionation and devitellinization of the silkworm eggs without damage, to facilitate the analysis of gene expression during embryonic development of Bombyx mori. Making use of antibodies available from heterologous systems, the spatio-temporal expression patterns of peroxidase and proliferating cell nuclear antigen have been directly visualized in whole mount embryos at various stages of development without the need for generating transformed ·lines carrying specific reporter constructs. The B. mori system, previously unamenable for such studies, could thus serve as an attractive model for molecular analysis of insect development.

The attention lavished on Drosophila melanogaster as …