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Organismal Biological Physiology Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Organismal Biological Physiology
Depemokimab: A Twice Yearly Anti-Il 5 Biologic For Chronic Rhinosinusitis With Nasal Polyps (Crswnp) - A Narrative Review, Marn Joon Park, Joseph K. Han, Kent K. Lam
Depemokimab: A Twice Yearly Anti-Il 5 Biologic For Chronic Rhinosinusitis With Nasal Polyps (Crswnp) - A Narrative Review, Marn Joon Park, Joseph K. Han, Kent K. Lam
Department of Otolaryngology (ENT) Faculty Publications
Depemokimab is a monoclonal antibody that targets interleukin-5 with enhanced binding affinity and an extended terminal elimination half‑life of 6-8 weeks. The unique pharmacodynamic features of depemokimab enable sustained suppression of type 2 inflammation with twice‑yearly subcutaneous dosing. This narrative review provides details of depemokimab's molecular profile, pharmacokinetics, and pharmacodynamics and results regarding the clinical efficacy and safety of depemokimab from recently published Phase 3 clinical trials for the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). In 528 severe adult CRSwNP patients (ANCHOR‑1/‑2 trials), depemokimab achieved Δ total endoscopic nasal polyp score by -0.70 (p < .001) and Δ nasal obstruction verbal response scale by -0.24 (p = .003) at week 52, compared to placebo. Twice‑yearly 100 mg depemokimab provides durable eosinophil suppression and with a safety profile comparable to placebo in Phase 3 trials for CRSwNP. Future work should refine biomarkers and assess comparative cost‑effectiveness and long‑term adherence, safety, and effectiveness.
Differences In Sideerophore Production During The Growth Of Phytoplankton In Southern Ocean Incubation Experiments Under High- And Low-Iron Conditions, Randelle M. Bundy, Kristen N. Buck, Bethany D. Jenkins, P. Dreux Chappell, Daniel J. Repeta, Alexa Sterling, Shannon M. Yang, Laura Holland, Léo Mahieu, Laura E. Moore
Differences In Sideerophore Production During The Growth Of Phytoplankton In Southern Ocean Incubation Experiments Under High- And Low-Iron Conditions, Randelle M. Bundy, Kristen N. Buck, Bethany D. Jenkins, P. Dreux Chappell, Daniel J. Repeta, Alexa Sterling, Shannon M. Yang, Laura Holland, Léo Mahieu, Laura E. Moore
OES Faculty Publications
Iron is an important micronutrient required by marine microorganisms. The Southern Ocean is an ecosystem where primary production is limited by the availability of iron, but how microorganisms in this region adapt to low-iron conditions or respond to episodic iron inputs is understudied. We tested how external iron additions would impact bacterial production of siderophores during phytoplankton growth using shipboard incubation experiments under a range of iron conditions. Similar heterotrophic bacteria communities and phytoplankton biomass were observed whether iron was added from the continental margin or as inorganic iron. Under both high- and low-iron conditions, the heterotrophic bacteria community remained …
Editorial: New Frontiers In The Application Of Stable Isotopes To Ecological And Ecophysiological Research, Keith A. Hobson, John P. Whiteman, Seth D. Newsome
Editorial: New Frontiers In The Application Of Stable Isotopes To Ecological And Ecophysiological Research, Keith A. Hobson, John P. Whiteman, Seth D. Newsome
Biological Sciences Faculty Publications
No abstract provided.