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Articles 31 - 37 of 37
Full-Text Articles in Bacteriology
Inhibition Of Escherichia Coli Atp Synthase By Polyphenols And Their Derivatives., Prasanna Keerthi Dadi
Inhibition Of Escherichia Coli Atp Synthase By Polyphenols And Their Derivatives., Prasanna Keerthi Dadi
Electronic Theses and Dissertations
We have studied the inhibitory effect of natural and structurally modified polyphenols on Escherichia coli ATP synthase to test (I) if the beneficial dietary effects of polyphenols are related to their inhibitory actions on ATP synthase, (II) if inhibitory effects of polyphenolic compound could be augmented through structural modifications, and (III) if they can act as antimicrobial agent through their actions on ATP synthesis. X-ray crystal structures of polyphenol binding sites suggested that polyphenols bind at a distinct polyphenol binding pocket, at the interface of α,β,γ-subunits. We found that both natural and modified polyphenols inhibit E. coli ATP synthase to …
Isolation And Identification Of The Siderophore "Vicibactin" Produced By Rhizobium Leguminosarum Atcc 14479., William H. Wright Iv
Isolation And Identification Of The Siderophore "Vicibactin" Produced By Rhizobium Leguminosarum Atcc 14479., William H. Wright Iv
Electronic Theses and Dissertations
Siderophores are small, iron chelating molecules produced by many bacteria to help meet the iron requirements of the cell. Multiple metabolic functions require iron as it serves as a cofactor in many enzymes and cellular processes. However, in the presence of oxygen and at physiologic pH, iron forms insoluble ferric complexes that cause the nutrient to be unavailable to bacterial cells. Siderophores alleviate this limitation by chelating the ferric iron, rendering it soluble and available for uptake. One group of microorganisms known for their ability to produce siderophores is the rhizobia. These bacteria are characterized both by their formation of …
Molecular Mechanism Of Ferricsiderophore Transport Via The Outer Membrane Receptor Fhua In Escherichia Coli., Jennifer K. Cooke
Molecular Mechanism Of Ferricsiderophore Transport Via The Outer Membrane Receptor Fhua In Escherichia Coli., Jennifer K. Cooke
Electronic Theses and Dissertations
Iron is essential for life and growth in most organisms. Although it is abundant, iron exists mostly as insoluble iron-oxyhydroxide. Bacteria secrete siderophores to chelate iron and transport it into the cell via specific outer membrane receptors. The FhuA receptor protein transports ferrichrome, a siderophore produced by Ustilago sphaerogena. We determined the binding affinity of variants from the conserved 'lock region' of FhuA and also created and characterized variants of the highly conserved R452 to determine its role in ferrichrome transport. We hypothesize that during transport the plug domain of FhuA does not leave the barrel; rather it undergoes …
Iron Acquisition In Rhodococcus Erythropolis Strain Igts8: Characterization Of A Mutant Strain That Over Produces Siderophore., Melanie Anne Pratt
Iron Acquisition In Rhodococcus Erythropolis Strain Igts8: Characterization Of A Mutant Strain That Over Produces Siderophore., Melanie Anne Pratt
Electronic Theses and Dissertations
Iron is an essential nutrient for most bacteria because enzymes like nitrate reductase and cytochromes use it as a cofactor. However, in most aerobic, neutral pH environments, iron is essentially insoluble and not easily available for bacteria to use. Many bacteria respond to this problem by releasing small organic compounds called siderophores that bind and effectively solubilize iron so that it can be transported into the cell for growth. The focus of this study was to learn more about the iron acquisition and especially the transport of iron by the soil bacterium Rhodococcus erythropolis. To fulfill this aim, mutant …
Identification Of Chlamydial Iron-Responsive Proteins During Intracellular Growth., Brian D. Dill
Identification Of Chlamydial Iron-Responsive Proteins During Intracellular Growth., Brian D. Dill
Electronic Theses and Dissertations
Chlamydia trachomatis is an obligate intracellular bacterium and the most prevalent cause of bacterial sexually transmitted disease. Genital chlamydial infections, marked by chronic, intense inflammation, can lead to genital tissue scarring and infertility and is a contributing factor to development of pelvic inflammatory disease and ectopic pregnancy. Iron is required as a cofactor for numerous highly conserved pathways, and nearly all studied organisms rely on iron for growth. In response to iron restriction, the chlamydial developmental cycle arrests at the intracellular reticulate body stage, resulting in a phenomenon termed persistence. Persistence likely plays a role in chlamydial pathogenesis through the …
Conjugative Transfer Pathways Of High-Level Mupirocin Resistance And Conjugative Transfer Genes In Staphylococcus., Danielle Barnard
Conjugative Transfer Pathways Of High-Level Mupirocin Resistance And Conjugative Transfer Genes In Staphylococcus., Danielle Barnard
Electronic Theses and Dissertations
To combat widespread infections caused by Staphylococcus aureus, mupirocin was introduced at the Veterans Affairs Medical Center, Mountain Home, Tennessee. Soon after introduction, high-level mupirocin-resistance emerged. The rapid emergence was hypothesized to be due to conjugative transfer of the mupA resistance gene from S. epidermidis to S. aureus. Results have shown that transfer of high-level mupirocin-resistance from S. aureus donors commonly occurs. However, transfer from naturally-occurring S. epidermidis donors was not attainable. Staphylococcus epidermidis transconjugants, however, were capable of serving as donors. Further examination of non-transmissibility included PCR analysis of conjugative transfer genes (tra genes) in capable …
The Cost Of Mupirocin Resistance In Staphylococcus., Susan D. Reynolds
The Cost Of Mupirocin Resistance In Staphylococcus., Susan D. Reynolds
Electronic Theses and Dissertations
Control of antibiotic resistance in bacteria is based on the concept that resistance incurs a fitness cost in non-selective conditions. Fitness costs were assessed for low- and high-level mupirocin resistance in locally-derived Staphylococcus aureus and S. epidermidis. Costs of resistance were assessed in pure cultures by comparing growth curve characteristics and in mixed culture as the proportion of resistant cells surviving. Costs were not present in comparisons of growth rates among groups of naturally-occurring isolates from the different resistance categories. However, in S. aureus, growth rates within resistance categories differed by approximately 30 – 90%. Among near-isogenic pairs …