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Exercise Science Commons™

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Himmelfarb Health Sciences Library, The George Washington University

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Articles 31 - 34 of 34

Full-Text Articles in Exercise Science

Differential Analysis Of Ovarian And Endometrial Cancers Identifies A Methylator Phenotype, Diana L. Kolbe, Julie A. Deloia, Patricia Porter-Gill, Mary Strange, Hanna M. Petrykowska, Alfred Guirguis, Thomas C. Krivak, Lawrence C. Brody, Laura Elnitski Mar 2012

Differential Analysis Of Ovarian And Endometrial Cancers Identifies A Methylator Phenotype, Diana L. Kolbe, Julie A. Deloia, Patricia Porter-Gill, Mary Strange, Hanna M. Petrykowska, Alfred Guirguis, Thomas C. Krivak, Lawrence C. Brody, Laura Elnitski

Exercise and Nutrition Sciences Faculty Publications

Despite improved outcomes in the past 30 years, less than half of all women diagnosed with epithelial ovarian cancer live five years beyond their diagnosis. Although typically treated as a single disease, epithelial ovarian cancer includes several distinct histological subtypes, such as papillary serous and endometrioid carcinomas. To address whether the morphological differences seen in these carcinomas represent distinct characteristics at the molecular level we analyzed DNA methylation patterns in 11 papillary serous tumors, 9 endometrioid ovarian tumors, 4 normal fallopian tube samples and 6 normal endometrial tissues, plus 8 normal fallopian tube and 4 serous samples from TCGA. For …


Independent Benefits Of Meeting The 2008 Physical Activity Guidelines To Insulin Resistance In Obese Latino Children, Nazrat Mirza, Matilde Palmer, Johanna O'Connell, Loretta Dipietro Jan 2012

Independent Benefits Of Meeting The 2008 Physical Activity Guidelines To Insulin Resistance In Obese Latino Children, Nazrat Mirza, Matilde Palmer, Johanna O'Connell, Loretta Dipietro

Exercise and Nutrition Sciences Faculty Publications

We examined the independent association between moderate-to-vigorous physical activity (MVPA) and insulin resistance (IR) among obese Latino children (� = 1 1 3; 7–15 years) who were enrolled in a community-based obesity intervention. Baseline information on physical activity was gathered by self-report. Clinical assessments of body composition, resting energy expenditure (REE), as well as glucose and insulin responses to an oral glucose tolerance test (OGTT) were performed after an overnight fast. Insulin resistance was defined as a 2 h insulin concentration >57 μU·mL−1. We observed that those obese children who met the 2008 Guidelines for MVPA (≥60 min/day) …


Successful Aging, Loretta Dipietro, Maria F. Singh, Roger Fielding, Hiroshi Nose Jan 2012

Successful Aging, Loretta Dipietro, Maria F. Singh, Roger Fielding, Hiroshi Nose

Exercise and Nutrition Sciences Faculty Publications

No abstract provided.


Response To Acute Psychophysical Stress And 24-Hour Glycemic Control In Healthy Older People, Loretta Dipietro, Catherine W. Yeckel, Andrei Gribok Jan 2012

Response To Acute Psychophysical Stress And 24-Hour Glycemic Control In Healthy Older People, Loretta Dipietro, Catherine W. Yeckel, Andrei Gribok

Exercise and Nutrition Sciences Faculty Publications

We examined the relation between stress reactivity and 24 h glycemic control in 17 inactive, healthy older people (≥60 years) under both a novel psychophysical stress and a seated control condition. Plasma cortisol was measured over the course of the stress and recovery periods. Glycemic control was determined over the subsequent 3 h from an oral glucose tolerance test (OGTT) and over 24 h viacontinuous glucose monitoring (CGM). We observed significant (� < 0 . 0 5) elevations in perceived stress, cardiovascular activity, and peak cortisol response at 30 min (1 0 . 6 ± 3 . 1 versus 8 . 6 ± 2 . 6 μg·dL−1, resp.) during the stress compared with the control condition; however, 3 h OGTT glucose and insulin responses were similar between conditions. The CGM data suggested a …