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Full-Text Articles in Other Immunology and Infectious Disease
Genomic Insights Into Mechanisms Of Microbial Evolution And Evolution-Inspired Strategies To Combat Pathogen Diversity, Saymon Akther
Genomic Insights Into Mechanisms Of Microbial Evolution And Evolution-Inspired Strategies To Combat Pathogen Diversity, Saymon Akther
Dissertations, Theses, and Capstone Projects
We live in an era of emerging infectious diseases that are increasingly common, rapidly spreading, and gravely devastating. Lyme disease, caused by bacteria belonging to the genus Borreliella, is rapidly rising in the Northern Hemisphere because of geographic range expansion of both the tick vectors and the pathogens. Evolutionary comparative analysis of Borreliella genomes is a key to understanding the phylogeographic history and mechanisms of their global diversification. Moreover, genomic variations in Borreliella associated with human pathogenicity, e.g., at loci encoding cell-surface antigens interacting with the vertebrate hosts, have not been fully identified. Similarly, the ongoing COVID-19 pandemic, caused …
Development And Maintenance Of The Thymic Epithelial Microenvironment, Shami Chakrabarti
Development And Maintenance Of The Thymic Epithelial Microenvironment, Shami Chakrabarti
Dissertations, Theses, and Capstone Projects
The thymus plays a critical role in adaptive immunity by providing a suitable microenvironment for developing and selecting the functional self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute age-related involution, which in turn causes loss of functional T-cell populations. Involution reduces the functionality of the thymus markedly, but the thymus can still develop self-tolerant naïve T-cells. It is crucial to understand how the thymic microenvironment is maintained to provide a suitable T-cell population for life. It has been previously demonstrated that the thymic epithelial homeostasis …