Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Cell Biology (2)
- Cell and Developmental Biology (2)
- Genetics and Genomics (2)
- Immune System Diseases (2)
- Immunity (2)
-
- Microbiology (2)
- Molecular Genetics (2)
- Biology (1)
- Cellular and Molecular Physiology (1)
- Developmental Biology (1)
- Digestive System Diseases (1)
- Food Microbiology (1)
- Food Science (1)
- Immunology of Infectious Disease (1)
- Immunoprophylaxis and Therapy (1)
- Immunotherapy (1)
- Nutrition (1)
- Other Immunology and Infectious Disease (1)
- Other Microbiology (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Physiology (1)
- Toxicology (1)
- Institution
- Keyword
-
- Aryl hydrocarbon receptor, B cell, mouse, mice, flow cytometry, in vitro, chemokine receptor 9, alpha4beta7, integrin, CCR, leukocyte trafficking, tissue homing, imprinting, immune activation, CH223191, C57BL/6, TCDD, sex (1)
- Autoimmune (1)
- Biological Sciences (1)
- Biological Sciences Student Work (1)
- Celiac Disease (1)
Articles 1 - 3 of 3
Full-Text Articles in Immunopathology
Examining The Ligands, Location, And Function Of Toll-Like Receptor 10, Kiefer Keanu Tam
Examining The Ligands, Location, And Function Of Toll-Like Receptor 10, Kiefer Keanu Tam
Master's Theses
Toll-like receptors are a class of innate immune pattern recognition receptors that detect pathogen-associated molecular patterns and regulate downstream inflammatory responses. Toll-like receptor 10 remains the only human TLR whose ligand specificity, cellular localization, and immunological function are not fully defined. Emerging evidence suggests that TLR10 may play an anti-inflammatory role and can heterodimerize with TLR2 to modulate immune signaling. Previous studies from our laboratory demonstrated that stimulation with heat-killed Mycobacterium tuberculosis promotes TLR2-TLR10 heterodimerization and trafficking to the cell surface. In this study, we expanded our ligand panel to include additional gram-positive bacteria, particularly anti-inflammatory probiotic species, to further …
The Role Of B Cell Activation State And Sex In Aryl Hydrocarbon Receptor Mediated Induction Of Chemokine Receptor 9 And Alpha4beta7 Expression In Vitro, Logan Bauerle
Master's Theses
Defense of mucosal tissues from microbial infection and allergy is reliant on continual production of antibodies. The aryl hydrocarbon receptor (AhR) is known to regulate B cell development and is associated with suppression of systemic humoral immunity. Recent attention has been paid to the role of the AhR in altering expression of cell adhesion molecules (CAMs). B cells express CAMs and chemokine receptors to migrate around the body for localized secretion of antibodies. AhR agonists promote B cell migration to the small intestine through upregulation of chemokine receptor 9 (CCR9) and integrin α4β7. Both the AhR …
Development Of A Prolyl Endopeptidase Expression System In Lactobacillus Reuteri To Reduce The Clinical Manifestation Of Celiac Disease, Kara Lynn Jew
Development Of A Prolyl Endopeptidase Expression System In Lactobacillus Reuteri To Reduce The Clinical Manifestation Of Celiac Disease, Kara Lynn Jew
Master's Theses
Celiac Disease (CD) is an autoimmune disorder that emerges due to the ingestion of gluten, a protein found in a variety of common grains such as wheat, rye, and barley. Approximately 1 in 100 individuals in the US suffer from CD, making it the most commonly diagnosed gastrointestinal disorder (Ciclitira et. al., 2005). These proline-rich gluten peptides are resistant to proteolysis and accumulate in the duodenum of the small intestine. Once in the duodenum, these peptides illicit an autoimmune response resulting in villous atrophy. Current treatment for CD requires a rigorous adherence to a gluten-free diet. Nevertheless, gluten-containing grains are …