Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- East Tennessee State University (3)
- Missouri State University (3)
- The Texas Medical Center Library (3)
- Touro College and University System (2)
- University of Connecticut (2)
-
- University of Kentucky (2)
- University of Nebraska Medical Center (2)
- University of New Mexico (2)
- Wayne State University (2)
- West Virginia University (2)
- American University in Cairo (1)
- Augustana College (1)
- Clemson University (1)
- Dartmouth College (1)
- Duquesne University (1)
- Louisiana State University (1)
- The University of Akron (1)
- The University of San Francisco (1)
- University of Arkansas, Fayetteville (1)
- University of Northern Colorado (1)
- Virginia Commonwealth University (1)
- Keyword
-
- Immunology (4)
- Macrophage (3)
- Sepsis (3)
- Autoimmunity (2)
- Bioinformatics (2)
-
- C-reactive protein (2)
- Immunity (2)
- Innate immunity (2)
- Macrophages (2)
- Streptococcus pneumoniae (2)
- Th17 (2)
- Toll-like receptor (2)
- 4-1BB (1)
- : IL-1β (1)
- ADAR1 (1)
- ADAR1p150 (1)
- AIDS (1)
- Adult (1)
- Aging (1)
- Allergic asthma (1)
- And metabolism (1)
- Angiotensin-converting enzyme (1)
- Anti-viral (1)
- Antibiotic resistance (1)
- Antibiotic sensitivity (1)
- Antibiotics (1)
- Arginase I (1)
- Aryl hydrocarbon receptor, B cell, mouse, mice, flow cytometry, in vitro, chemokine receptor 9, alpha4beta7, integrin, CCR, leukocyte trafficking, tissue homing, imprinting, immune activation, CH223191, C57BL/6, TCDD, sex (1)
- Asthma (1)
- Atopic dermatitis (1)
- Publication Year
- Publication
-
- Electronic Theses and Dissertations (4)
- Dissertations and Theses (Open Access) (3)
- Graduate Theses/Dissertations (3)
- Biomedical Sciences ETDs (2)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (2)
-
- Master's Theses (2)
- NYMC Student Theses and Dissertations (2)
- Theses & Dissertations (2)
- Theses and Dissertations (2)
- University Scholar Projects (2)
- All Theses (1)
- Biology: Student Scholarship & Creative Works (1)
- Dartmouth College Ph.D Dissertations (1)
- Graduate Theses and Dissertations (1)
- Honors College Theses (1)
- LSU Doctoral Dissertations (1)
- Medical Student Research Symposium (1)
- Theses and Dissertations--Veterinary Science (1)
- University of Kentucky Doctoral Dissertations (1)
- Williams Honors College, Honors Research Projects (1)
- Publication Type
Articles 31 - 34 of 34
Full-Text Articles in Immunopathology
Comparison Of Anti-Pneumococcal Functions Of Native And Modified Forms Of C-Reactive Protein, Donald Neba Ngwa
Comparison Of Anti-Pneumococcal Functions Of Native And Modified Forms Of C-Reactive Protein, Donald Neba Ngwa
Electronic Theses and Dissertations
The anti-pneumococcal function of native C-reactive protein (CRP) involves its binding to phosphocholine molecules present on Streptococcus pneumoniae and subsequent activation of the complement system. However, when pneumococci recruit complement inhibitory protein factor H on their surface, they escape complement attack. Non-native forms of CRP have been shown to bind immobilized factor H. Accordingly, we hypothesized that modified CRP would bind to factor H on pneumococci, masking its complement inhibitory activity, allowing native CRP to exert its anti-pneumococcal function. As reported previously, native CRP protected mice from lethal pneumococcal infection when injected 30 minutes before infection but not when injected …
Role Of Viral And Host Factors In Influenza Virus Mediated Inhibition Of Interleukin-23, Ashish Tiwari
Role Of Viral And Host Factors In Influenza Virus Mediated Inhibition Of Interleukin-23, Ashish Tiwari
Theses and Dissertations--Veterinary Science
Influenza virus is one of the major respiratory pathogens of humans as well as animals, including equines. There is an increasing evidence that bacterial infections are the most common cause of the death during influenza. In horses also, secondary bacterial pneumonia can lead to death, and surviving horses may take up to six months for the complete recovery resulting in heavy economic loss to the equine industry. Interleukin (IL)-23 mediated innate immune response has been shown to protect the host from various respiratory bacterial infections. However, studies to investigate the role of host and viral factors in the regulation of …
Role Of Pi3k-Akt Pathway In The Age Associated Decline In Tlr Mediated Activation Of Innate And Adaptive Immune Responses, Mosoka Papa Fallah
Role Of Pi3k-Akt Pathway In The Age Associated Decline In Tlr Mediated Activation Of Innate And Adaptive Immune Responses, Mosoka Papa Fallah
University of Kentucky Doctoral Dissertations
Immunosenescence results in reduced immune response to infections with Streptococcus pneumoniae as well as to pneumococcal polysaccharide vaccines. The antibody response to the capsular polysaccharide (CPS) provides protection against S. pneumoniae infection. CPS immunoresponse is T cell independent and needs the macrophage-derived cytokines such as IL-12, IL-6 and IL-1β to elicit an antibody response. We showed a cytokine dysregulation, i.e. a decrease in IL-12, IL-6 and TNF-α but an increase in IL-10, in the aged (18-24 months old comparable to >65 years in human) compared to young adult mouse (8-12 weeks less than 65 years old) splenic macrophages (SM) or …
Immune Recognition Of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity, Dipyaman Ganguly
Immune Recognition Of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity, Dipyaman Ganguly
Dissertations and Theses (Open Access)
Innate immune recognition of extracellular host-derived self-DNA and self-RNA is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with the endogenous cationic antimicrobial peptide LL37, which are internalized into the endosomal compartments and thus can access TLR9. We investigated whether this endogenous peptide can also interact with extracellular self-RNA and lead to DC activation. We found that LL37 binds self-RNA as well as self-DNA going into an electrostatic interaction; forms micro-aggregates of nano-scale particles protected from …