Immunology of Infectious Disease Commons^™

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

Undergraduate Research Posters

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …

Characterization Of A Putative Hemolysin Expressed By Sneathia Amnii, A Preterm Birth-Associated Pathogen, Lizette Carrasco, Kimberly Jefferson

Undergraduate Research Posters

The gram-negative bacteria Sneathia amnii is a poorly-characterized commensal of the female urogenital tract frequently associated with adverse clinical outcomes such as bacterial vaginosis (BV), amnionitis, and preterm labor. To investigate its potential role in virulence, we sought to identify and characterize virulence determinants produced by S. amnii in an effort to better understand the pathogenesis of infectious preterm birth. Through sequencing of the Sn35 genome (type strain of S. amnii), we identified two genes with amino acid sequence similarity and structural similarity to the filamentous hemagglutinin (FHA) protein of Bordetella pertussis and its Type Vb transporter. Because S. amnii …

Fisheries Research Contract Report No. 15 - Aquatic Animal Health Subprogram: Pilchard Herpesvirus Infection In Wild Pilchards (Frdc Project No. 2002/044) Final Report, Brian Jones, Melanie Crockford, Richard Whittington, Mark Crane, Graham Wilcox

Fisheries Research Contract Reports

In 1995 and again in 1998/9, millions of pilchards (Sardinops sagax neopilchardus) were found dead or dying off the coast of Australia. Some pilchards in New Zealand were also affected during the 1995 epizootic. The epizootics moved progressively in a "bushfire-like" manner against the prevailing currents at a rapid speed. An uncharacterised herpesvirus, pilchard herpesvirus (PHV), was associated with both mortality events and, based on its occurrence in affected fish and the disease pathogenesis, generally accepted as the causative agent, although experimental evidence of its role was not established. Until recently, rapid and sensitive methods to detect PHV were not …

Current Issues And Future Directions In The Scientific Response To The Aids Epidemic, Anthony S. Fauci

DSLS 1988-1989

(Abstract taken from the Distinguished Scientist Lecture Series Program 1988-1989).

The recording is unavailable.

Dr. Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institute of Health (NIH), also serves as the Associate Director of the NIH for research on the acquired immunodeficiency syndrome (AIDS) and as Director of the NIH Office of AIDS Research. A native of Brooklyn, New York, Dr. Fauci received his M.D. degree from Cornell University Medical College in 1966. After completing an internship at Cornell Medical Center in New York City, he began his work at the NIH as …