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Full-Text Articles in Immunity
Lactobacillus Metabolite Nc As An Inflammation Inhibitor, Drew Hahnnah Landrowski
Lactobacillus Metabolite Nc As An Inflammation Inhibitor, Drew Hahnnah Landrowski
Master's Theses
The human body contains a diverse ecosystem of microbes. Commensal bacteria have numerous mutually-beneficial relationships with their host. Not only do they assist in digestion and gut homeostasis, they are critical for development and function of the immune system. As such, hosts and microbes alike have evolved mechanisms to foster symbiosis. Gut barrier function, toll-like receptor signaling, and metabolites are all examples of how hosts interact with microbes to promote this mutually-beneficial relationship. Metabolites from commensal bacteria promote the generation of regulatory T-cells, capable of ameliorating inflammation. A number of inflammatory, allergic, and autoimmune conditions are associated with dysbiosis. Therefore, …
Elucidating The Mechanisms Underlying How Vmp1 Regulates Inflammatory Responses, Stephanie Zack
Elucidating The Mechanisms Underlying How Vmp1 Regulates Inflammatory Responses, Stephanie Zack
Dissertations
autophagy, inflammation, mitochondria, NLRP3 inflammasome, SERCA, VMP1
Elucidating The Mechanisms Of Immune Regulation By Bacillus Subtilis, Jesus Zamora-Pineda
Elucidating The Mechanisms Of Immune Regulation By Bacillus Subtilis, Jesus Zamora-Pineda
Dissertations
bacillus subtilis, exopolysaccharides, inflammation, probiotics, tlr4
B Cells In The Gut Associated Lymphoid Tissue (Galt), Ameera Bukhari
B Cells In The Gut Associated Lymphoid Tissue (Galt), Ameera Bukhari
Dissertations
The gut-associated lymphoid tissue (GALT) is the largest mass of lymphoid tissue in the body, and it is a unique line of defense where immune cells are in constant contact with gut commensals and pathogens. B lymphocytes constitute most of the lymphatic tissues of the gastrointestinal (GI) tract and they play a critical role in protecting from infections, promoting tolerance, and shaping microbiota in the gut through the production of immunoglobulins (Ig). Previous studies on GALT B cells in human showed that large B cell clones in the body partition into two broad networks: one includes the blood, bone marrow, …
The Role Of Ly49 Receptors In Maintaining Healthy Murine Pregnancy, Michelle Belmont
The Role Of Ly49 Receptors In Maintaining Healthy Murine Pregnancy, Michelle Belmont
Master's Theses
Natural Killer (NK) cells are abundant in pregnancy and contribute to the health of the fetus. Uterine NK (uNK) cells provide less cytotoxic function than their conventional NK (cNK) cell counterparts. Various combinations of Killer Immunoglobulin Receptor (KIR)- Human Leukocyte Antigen (HLA) on maternal NK and fetally derived cells, respectively, can have different effects on the health of pregnancy in humans. Murine NK cells contain Ly49 receptors, an equivalent to KIRs. Therefore, Ly49 receptor interactions with fetally-derived MHC-I molecules can be a valuable model for studying the role of NK cells in pregnancy. The process of spiral artery remodeling can …
Phenotypic Analysis Of Murine Gut Associated Lymphocytes, Madison Flood
Phenotypic Analysis Of Murine Gut Associated Lymphocytes, Madison Flood
Master's Theses
γδ T cells are important in the role of immune homeostasis, especially in relation to the gut. It has been shown that there is a higher proportion of γδ T cells in the intestines than in circulation. With this knowledge, our lab focused on understanding the mechanisms of these cells, specifically regarding immune tolerance. In our preliminary research, we identified a subset of γδ T cells that express Foxp3, a transcription factor essential for the functioning of regulatory T cells, in the neonatal (5 day old) intestine. We hypothesized that these Foxp3+ γδ T cells have immunosuppressive functions upon exposure …