Immunology and Infectious Disease Commons^™

Autoimmunity, Immune Deficiency And Cancer: Multiple Roles Of The Protein Tyrosine Phosphate Shp-1, Melissa J. Joliat

Electronic Theses and Dissertations

One of a large number of mutant mice used in immunological research, the "motheaten" mouse was the first model of a specific protein tyrosine phosphatase deficiency. Mice carrying one of two allelic mutations at the "motheaten" locus have severe systemic autoimmunity and immune dysfunction as a result of mutations in the hematopoietic-cell phosphatase (Hcph) gene, which encodes the protein tyrosine phosphatase SHP-1. Studies using "motheaten" (me/me) and "viable motheaten" (me^v/me^v) mice have increased the understanding of numerous signaling pathways in immune and hematopoietic cells. A number of studies on SHP-1 function …

Distribution And Impact Of The Oyster Parasite Bonamia Ostreae In Maine, And Its Detection Using Dna Probes, Ryan Carnegie

Electronic Theses and Dissertations

Health management efforts in Maine related to the flat oyster (Ostrea edulis) parasite Bonamia ostreae are limited by a lack of knowledge of the parasite’s distribution and impact in both wild and cultured populations. This information would be more readily obtainable with improved diagnostic tools. The objectives of this dissertation were to design sensitive and specific DNA probes for detection of B. ostreae; to assess the prevalence and intensity of parasite infections in wild oyster populations in Maine; and to evaluate growth and mortality of cultured oysters in the Damariscotta River, where B. ostreae is enzootic. A polymerase …

Explorations, Vol. 4, No. 2, Carole J. Bombard, Richard G. Emerick, James A. Sherburne, Robert Brinkley, Susan Grindel, Roberta Chester, Anne P. Sherblom, Charles E. Moody, Diane Carroll, Barbara Barton

Explorations — A Journal of Research

Articles include:

Cover: Maya—painted clay figure from Jaina Island, Campeche, Mexico, 500-700A. D., approximately 100 percent. The clay figure is from a superb assemblage of pre-Hispanic materials from Mexico and Central America donated to the University of Maine’s Hudson Museum from the estate of William P Palmer III. In addition to this fine collection, Palmer donated an extensive array of objects from the Northwest Coast. Palmer earned his undergraduate degree in history and government from the University of Maine, and remained a strong, active supporter of the institution throughout his lifetime. More examples of objects from the Palmer Collection, including …

Explorations, Vol. 3, No. 2, Maryann Jerkofsky, David H. Clark, David Ebitz, Alan Davenport, David C. Smith, Erodgan Kiran

Explorations — A Journal of Research

Cover: Edmund G. Schildknecht, Seated Figure, 1929, oil on canvas, 30” x 25”, acc. no. 85.6.31, bequest of Edmund G. Schildknecht

Articles include:
"Reyes Syndrome Under Attack at UMaine," by MaryAnn Jerkofsky

"Maine Service Abroad: Using Labor Market Results for Planning Education and Training in Developing Countries," by David H. Clark

"Feeling and Form: Four American Paintings in the University of Maine Art Collection," by David Ebitz

"We Stand Corrected," Volume 3, Number 1, of EXPLORATIONS

"Confessions of a Comet Huckster," by Alan Davenport

"H.G. Wells: Socialist, Feminist, Polymath, Educator and Hero," by David C. Smith

"Supercritical Fluids and …