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Full-Text Articles in Immunology and Infectious Disease

The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman May 2020

The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman

Honors College

Mycobacterium tuberculosis is the leading cause of death by an infectious disease (MacNeil, 2019). In 2018, 10 million people developed tuberculosis and half a million infections were resistant to antibiotics (WHO, 2019). Nearly all members of the M. tuberculosis complex are lysogens, meaning they carry prophage, or integrated viral genomes within the host genome (Fan et al., 2016). The non-pathogenic vaccine strain (M. bovis Bacillus Calmette–Guérin (BCG)) is the exception, which suggests prophage play a role in virulence (Fan et al., 2016). Because not all prophage encode obvious virulence genes, we hypothesize that prophage impact bacterial virulence by altering bacterial …


Intravital Imaging In A Zebrafish Model Elucidates Interactions Between Mucosal Immunity And Pathogenic Fungi, Linda S. Archambault Aug 2019

Intravital Imaging In A Zebrafish Model Elucidates Interactions Between Mucosal Immunity And Pathogenic Fungi, Linda S. Archambault

Electronic Theses and Dissertations

Candida yeasts are common commensals that can cause mucosal disease and life-threatening systemic infections. While many of the components required for defense against Candida albicans infection are well established, questions remain about how various host cells at mucosal sites assess threats and coordinate defenses to prevent normally commensal organisms from becoming pathogenic. Using two Candida species, C. albicans and C. parapsilosis, which differ in their abilities to damage epithelial tissues, we used traditional methods (pathogen CFU, host survival, and host cytokine expression) combined with high-resolution intravital imaging of transparent zebrafish larvae to illuminate host-pathogen interactions at the cellular level …


The Effect Of Wild Blueberry Anthocyanins And Phenolic Acids On Innate Immunity: The Compliment System, Vasiliki Papakotsi Aug 2018

The Effect Of Wild Blueberry Anthocyanins And Phenolic Acids On Innate Immunity: The Compliment System, Vasiliki Papakotsi

Electronic Theses and Dissertations

Ingestion of berries containing polyphenols is associated with lower risk of inflammatory, metabolic, cardiovascular and degenerative diseases. Diet has been shown to modulate the activation of the complement system, a set of over 50 proteins present in the circulation and tissues that reacts in response to damage or microbial encounter and is critical for the maintenance of homeostasis. Imbalanced activation is tightly correlated with inflammation and various pathologies. Wild blueberries are a rich source of anthocyanins and phenolic acids, which can be found in plasma shortly after consumption. Given the involvement of both complement and polyphenols in the modulation of …


Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke Aug 2016

Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke

Electronic Theses and Dissertations

Molecular camouflage is used by a diverse set of pathogens to disguise their identity and avoid recognition by protective host receptors. The opportunistic fungal pathogen Candida albicans is a good example, as it masks the inflammatory component β-glucan in its cell wall to evade detection by the immune receptor Dectin-1. Interestingly, it has been seen that β-glucan becomes unmasked during infection in vivo, though the underlying mechanisms remained unclear. Exposure levels of this epitope may be important, as Dectin-1 mediates protection from some strains of C. albicans and alterations in the organization and composition of the Candida cell wall …


Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz Jun 2016

Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa Jun 2016

Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan Jun 2016

Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-Ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai Jun 2016

Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-Ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy Jun 2016

Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, Kai Kristoffer Lie Phd, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor Jun 2016

Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, Kai Kristoffer Lie Phd, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen Jun 2016

Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh Jun 2016

Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu Jun 2016

White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng Jun 2016

Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen Jun 2016

Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


The Expression Analysis Of Per1 Gene In Fugu, Takifugu Rubripes Administered With Immunostimulants, Goshi Nishi, Jun-Ichi Hikima Dr., Masahiro Sakai, Tomoya Kono Jun 2016

The Expression Analysis Of Per1 Gene In Fugu, Takifugu Rubripes Administered With Immunostimulants, Goshi Nishi, Jun-Ichi Hikima Dr., Masahiro Sakai, Tomoya Kono

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Combined Effects Of Dietary Mannan Oligosaccharides And Pediococcus Acidilactici And Their Combination In Low Fish Meal And Fish Oil Diets For European Sea Bass, Dicentrarchus Labrax, Juveniles, Fernando Rivero-Ramírez, Silvia Torrecillas, Maria José Caballero, Alex Makol, Marisol Izquierdo, Daniel Montero Jun 2016

Combined Effects Of Dietary Mannan Oligosaccharides And Pediococcus Acidilactici And Their Combination In Low Fish Meal And Fish Oil Diets For European Sea Bass, Dicentrarchus Labrax, Juveniles, Fernando Rivero-Ramírez, Silvia Torrecillas, Maria José Caballero, Alex Makol, Marisol Izquierdo, Daniel Montero

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Expression Kinetics Of Interferon Stimulated Genes In Atlantic Salmon Head Kidney Cells (Ask) Nucleofected With Poly(I:C), Adriana Magalhaes Santos Andresen 19821, Tor Gjøen Jun 2016

Expression Kinetics Of Interferon Stimulated Genes In Atlantic Salmon Head Kidney Cells (Ask) Nucleofected With Poly(I:C), Adriana Magalhaes Santos Andresen 19821, Tor Gjøen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Three Hamp Genes Of Nile Tilapia Were Differentially Activated In Spleen To Defend Against Streptococcus Iniae Infection, Hong-Yi Gong, Chia-Hui Ho, Sheng-Han Wu, Wen-Fu Lin, Yi-Hsuan Kuo, Yu-Hsuan Chang Jun 2016

Three Hamp Genes Of Nile Tilapia Were Differentially Activated In Spleen To Defend Against Streptococcus Iniae Infection, Hong-Yi Gong, Chia-Hui Ho, Sheng-Han Wu, Wen-Fu Lin, Yi-Hsuan Kuo, Yu-Hsuan Chang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai Jun 2016

Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang Jun 2016

Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization Of A New Protein Interacting With The Antimicrobial Peptide Scy2 From Scylla Paramamosain, Ying Yang Jun 2016

Characterization Of A New Protein Interacting With The Antimicrobial Peptide Scy2 From Scylla Paramamosain, Ying Yang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Optimization Of A Plaque Neutralization Test Capable Of Assessing The Exposure History Of Pacific Herring To Viral Hemorrhagic Septicemia Virus, Ashley Mackenzie Jun 2016

Optimization Of A Plaque Neutralization Test Capable Of Assessing The Exposure History Of Pacific Herring To Viral Hemorrhagic Septicemia Virus, Ashley Mackenzie

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Beef Cattle Herd Health Management Guide For Maine #1031, Donna Coffin Jan 2014

Beef Cattle Herd Health Management Guide For Maine #1031, Donna Coffin

Cooperative Extension - Agriculture

A herd health management plan is vital to profitable beef production. Do not wait until a disease outbreak occurs before implementing a sound herd health program. For cattle to reach their performance potential, they must be healthy. Vaccinations are an approved practice for organic producers. 5 pages. © 2014 by University of Maine Cooperative Extension.


Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter May 2013

Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter

Honors College

The innate immune system is highly conserved amongst all multicellular organisms. Yet a constant battle exists between host cells and pathogens due to the rapid evolution of immune system components. Functional genomics and in silico methods can be employed to elucidate the evolutionary patterns of vertebrate immunity to pathogenic fungi such as Candida albicans, an opportunistic fungal pathogen that can cause lethal candidiasis in the immunocompromised. Mammals such as humans and mice possess conserved C-type lectin receptors that recognize the C. albicans cell wall. However, these receptors have not been identified in fish. Here I describe how we identified potential …