Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics (3)
- Medicine and Health Sciences (3)
- Biochemistry, Biophysics, and Structural Biology (2)
- Bioethics and Medical Ethics (2)
- Cell Biology (2)
-
- Cell and Developmental Biology (2)
- Molecular Biology (2)
- Molecular Genetics (2)
- Biochemistry (1)
- Biotechnology (1)
- Chemicals and Drugs (1)
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
- Developmental Biology (1)
- Diseases (1)
- Education (1)
- Educational Technology (1)
- Genetic Structures (1)
- Genomics (1)
- Immune System Diseases (1)
- Immunology and Infectious Disease (1)
- Medical Biochemistry (1)
- Medical Biotechnology (1)
- Medical Genetics (1)
- Medical Humanities (1)
- Medical Sciences (1)
- Microbiology (1)
- Nucleic Acids, Nucleotides, and Nucleosides (1)
- Institution
- Publication
- Publication Type
Articles 1 - 5 of 5
Full-Text Articles in Other Genetics and Genomics
Reverse Micelles Produce Hydroxyapatite Nanoparticles As More Efficient Gene Delivery Carriers Than Regular Micelles, Vuk Uskoković
Reverse Micelles Produce Hydroxyapatite Nanoparticles As More Efficient Gene Delivery Carriers Than Regular Micelles, Vuk Uskoković
Administration and Staff Articles and Research
Hydroxyapatite (HAp) is an effective inorganic gene delivery carrier due to its ability to transport genetic cargo across cell membranes, protect it from proteolysis, and enable escape from late endosomes via pH-controlled dissolution. However, its transfection efficiency remains lower than that of viral agents, prompting studies of hybrids with cationic molecules or phases to enhance the gene delivery performance. This study reports on the synthesis of HAp in regular and reverse micellar regions of a ternary microemulsion system composed of cetyltrimethylammonium bromide (CTAB), 1-hexanol and water. Spectroscopic characterization revealed that CTAB headgroups adopted more ordered supramolecular conformations in reverse micelles …
Artificial Intron Technology To Generate Conditional Knock-Out Mice, Amber N. Thomas-Gordon
Artificial Intron Technology To Generate Conditional Knock-Out Mice, Amber N. Thomas-Gordon
Dissertations and Theses (Open Access)
Genetic engineering has been re-shaped by the invention of new tools in modern biotechnology in a way that offers precision and efficiency in modifying the genome at a single nucleotide level and/or allowing precise control of gene expression. Such gene manipulation brings about significant findings and revelations in comprehending more about embryonic development, cellular and physiological functions, and disease pathology. Current methods used to produce conditional knockouts have limitations on conditional allele placement and modification varies among genes in different organisms. Thus, a system for generating conditional alleles with fidelity remains a challenge. My goal was to examine an approach …
Eugenics In The 21st Century, Jessica Linn Chin
Eugenics In The 21st Century, Jessica Linn Chin
Dissertations, Theses, and Capstone Projects
Eugenics is the science of enhancing the human population through the management of breeding and hereditary traits. This thesis explores the history of eugenics and shows how eugenic practices continue in the 21st century with advancements in technology and positive eugenic goals that can result in adverse effects on the human body and society. When Sir Francis Galton coined the term eugenics in 1883, he intended to improve British society with the use of positive eugenics. Galton used positive eugenics to encourage people with good mental and physical qualities to produce more children. He avoided negative eugenics, which involved …
Characterization Of Induced Rnai Silencing Of Vaccinia Virus Essential Genes, Kewa Jiang
Characterization Of Induced Rnai Silencing Of Vaccinia Virus Essential Genes, Kewa Jiang
University Scholar Projects
Vaccinia virus (VACV) is a large double-stranded DNA virus and the prototypical member of the family Poxviridae and is most notable for its use as the vaccine that eradicated smallpox (variola virus). More recently, VACV has been used to develop recombinant vaccines and immunotherapies. However, many of these processes require VACV replication to be tightly controlled. RNA interference (RNAi) is a powerful tool for in vitro silencing of mRNAs that are complimentary to 19-21 base pairs (bp) of double-stranded RNA (dsRNA). This project outlines the design and preliminary analysis of two inducible RNAi silencing constructs targeting multiple VACV essential genes …
The Biotech Century (Book Review), Philip A. Reed
The Biotech Century (Book Review), Philip A. Reed
STEMPS Faculty Publications
No abstract provided.