Other Genetics and Genomics Commons^™

Differential Methylation Methods In Multi-Context Organisms, Douglas Baumann, Yuqing Su, Iranga Mendis, Gayla R. Olbricht

Conference on Applied Statistics in Agriculture

DNA methylation is an epigenetic modification that has the ability to alter gene expression without any change in the DNA sequence. DNA methylation occurs when a methyl chemical group attaches to cytosine bases on the DNA sequence. In mammals, DNA methylation primarily occurs at CG sites, when a cytosine is followed by a guanine in the DNA sequence. In plants, DNA methylation can also occur in other cytosine sequences, such as when a cytosine is not followed directly by a guanine. Many of the statistical methods that have been developed to estimate methylation levels and test differential methylation in whole-genome …