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Articles 1 - 5 of 5
Full-Text Articles in Population Biology
Forest Or Phylogeny?: Untangling Phylogenetic Signal From Selection Pressure Using Barronopsis Texans, Alexandra I. Chatman
Forest Or Phylogeny?: Untangling Phylogenetic Signal From Selection Pressure Using Barronopsis Texans, Alexandra I. Chatman
Chancellor’s Honors Program Projects
No abstract provided.
A Homogenizing Process Of Selection Has Maintained An 'Ultra-Slow' Acetylation Nat2 Variant In Humans, Blandine Patillon, Pierre Luisi, Estella S. Poloni, Sotiria Boukouvala, Pierre Darlu, E. Genin, Audrey Sabbagh
A Homogenizing Process Of Selection Has Maintained An 'Ultra-Slow' Acetylation Nat2 Variant In Humans, Blandine Patillon, Pierre Luisi, Estella S. Poloni, Sotiria Boukouvala, Pierre Darlu, E. Genin, Audrey Sabbagh
Human Biology Open Access Pre-Prints
N-acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation have been described for the main slow acetylation variants of the NAT2 gene, suggesting the action of natural selection at this locus. In the present study, we took advantage of the whole-genome sequence data available from the 1000 Genomes project to investigate the …
Celiac Disease As A Model For The Evolution Of Multifactorial Disease In Humans, Aaron Sams, John Hawks
Celiac Disease As A Model For The Evolution Of Multifactorial Disease In Humans, Aaron Sams, John Hawks
Human Biology Open Access Pre-Prints
Celiac disease (CD) is a multifactorial chronic inflammatory condition that results in injury of the mucosal lining of the small intestine upon ingestion of wheat gluten and related proteins from barley and rye. Although the exact mechanisms leading to CD are not fully understood, the genetic basis of CD has been relatively well characterized. In this review we briefly review the history of discovery, clinical presentation, pathophysiology, and current understanding of the genetics underlying CD risk. Then, we discuss what is known about the current distribution and evolutionary history of genes underlying CD risk in light of other evolutionary models …
Alfred Russel Wallace, Geographer, Charles H. Smith
Alfred Russel Wallace, Geographer, Charles H. Smith
DLPS Faculty Publications
Among the great explorers and thinkers who advanced geography in the nineteenth century and helped it evolve into the subject that exists today is a man who is not always connected with the field, Alfred Russel Wallace (1823–1913). Most commonly recognized as ‘the other man’ in the history of the discovery of the principle of natural selection, Wallace’s commitment to the study of landscape and its physical, biological, and human elements was lifelong, and resulted in a wide range of contributions to biogeography, physical geography, human geography, and ethnography. In this year of the double anniversaries of Charles Darwin’s birth …
A Sex Difference In Seasonal Timing Of Birth In A Livebearing Fish, Eric T. Schultz
A Sex Difference In Seasonal Timing Of Birth In A Livebearing Fish, Eric T. Schultz
EEB Articles
Sex differences in seasonal timing include differences in hatch- or birth-date distribution and differences in the timing of migration or maturation such as protandrous arrival timing (PAT), which is early male arrival at breeding sites. I describe a novel form of protandrous arrival timing, as a sex difference in birth-date distribution in a live-bearing fish (Dwarf Perch, Micrometrus minimus). In this species, birth coincides with arrival at breeding sites because newborn males are sexually active. A series of samples of pregnant females and young of year was collected in Tomales Bay, CA. I analyzed the daily age record in otoliths …