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Articles 1 - 14 of 14
Full-Text Articles in Other Cell and Developmental Biology
Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy
Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy
BAU Journal - Science and Technology
Worldwide, bone fractures are a major public health concern and, there is an urgent requirement to create new treatments to accelerate the rate of the bone healing process. This research mainly relies on creating a hydrogel that satisfies the bone marrow mesenchymal stem cells (BM-MSCs) and makes it a suitable medium to differentiate into osteogenic cells. We combine the BM-MSCs with a chitosan polymer-based hydrogel, infused with PVA to enhance bone healing, this unique mixture forms " Bioink ". We induced a closed fracture model in the rat's right humerus, followed by injection of a single dosage of bioink. On …
Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen
Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen
Presidential Fellows Articles and Research
Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recognition theory that currently dominates innate immunology. Focusing on early host responses to virus infections, we analyze the literature to build a working hypothesis for the principles that govern the early line of cellular antiviral defense. Aiming to ultimately arrive at a criteria-based theory with strong explanatory power, we propose that both controlling infection and limiting inflammation are key drivers for the early cellular antiviral …
Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi, Ayan K. Barui, Ashraf M. Mohieldin, Ankan Gupta, Ramani Ramachandran, Surya M. Nauli
Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi, Ayan K. Barui, Ashraf M. Mohieldin, Ankan Gupta, Ramani Ramachandran, Surya M. Nauli
Pharmacy Faculty Articles and Research
Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, underlining its potential role in cancer. However, the correlation between primary cilia and miR-17 has yet to be fully elucidated. The present study examines the presence of miR-17 in primary cilia. The miR-17 expression is studied in selected ciliary protein knockdown cells. Using in situ hybridization (ISH), we identified the subcellular localization of miR-17 in both cilium and cell body. We confirmed the importance …
Investigating The Cellular Mechanisms Of Intracellular Ph Regulation During Exposure To High Co2., Dillon Flowers
Investigating The Cellular Mechanisms Of Intracellular Ph Regulation During Exposure To High Co2., Dillon Flowers
Biology Theses
There are at least two different strategies of pH regulation among fish. The first is coupled pH regulation (CPR), where regulation of blood pH facilitates tissue pH regulation; and the second is preferential intracellular pH (pHi) regulation (PPR), where tissue pH remains tightly regulated despite a sustained reduction in blood pH. The cellular and molecular mechanisms underlying the differences in pHi regulation are currently unknown. I investigated the mechanisms of pH regulation in fishes using Rainbow Trout (Oncorhynchus mykiss) and Channel Catfish (Ictalurus punctatus) which use CPR and PPR, respectively. Fish were exposed to elevated CO …
Omani Camels From A Cultural And Genomics Perspective, Al Muatasim Al Zadjali
Omani Camels From A Cultural And Genomics Perspective, Al Muatasim Al Zadjali
Electronic Theses and Dissertations
The Dromedarian camel, Camelus dromedarius, is native to the Arabian Peninsula, including the Sultanate of Oman. These camels are used for food, milk, as well as show and racing competitions. Despite their economic and cultural importance research on camels in Oman is limited. The goal of this study was to examine their genomic variation, relationship with camels in other parts of the Arabian Peninsula, and to determine if selective breeding has led to the establishment of distinct breeds in Oman. Information was compiled from multiple sources to produce a comprehensive review on the breeding, management, economic and cultural use, …
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez
Electronic Theses, Projects, and Dissertations
Neural stem cell therapies represent a promising tool for the development of regenerative medicine and are being tested in clinical trials for several neurological disorders. However, the clinical applicability of stem cell therapies is dependent on the implementation of current good manufacturing practices (cGMPs) to ensure the quality, safety, and consistency that stem cell products need to meet FDA regulatory requirements. As such, there is a need for a shift to xeno-free methodologies so experimental conditions are cGMP compliant. The purpose of this study is to test a GMP compatible production method to generate multipotent neural stem cells (NSCs) from …
The Effect Of Yamanaka Factors On The Metastatic Potential Of Breast Cancer Cells, Riley Mendonca
The Effect Of Yamanaka Factors On The Metastatic Potential Of Breast Cancer Cells, Riley Mendonca
Undergraduate Honors Theses
The mortality associated with cancer is most commonly a result of it spreading to other tissues and organs in a process known as metastasis. For carcinomas to do this they must first break through the basement membrane containing them to interact with the stroma. This is known as an epithelial-mesenchymal transition and occurs when carcinomas suppress their original epithelial qualities in order to adopt more mesenchymal ones. This involves cancers dedifferentiating from their original cell type to lose the specialized features that distinguished them and where they came from. As cancers become more invasive, this dedifferentiation becomes more pronounced. Recent …
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Dissertations and Theses (Open Access)
Operant conditioning (OC) is a form of associative learning in which an animal modifies its behavior based on the consequences that follow that behavior. Despite its ubiquity, the underlying mechanisms of OC are poorly understood. Insights into the mechanisms of OC can be obtained by studying Aplysia feeding behavior as it can be modified by OC. This behavior is mediated by a central pattern generator (CPG) network in the buccal ganglia that contains a relatively small number of neurons. This CPG generates rhythmic motor patterns (BMPs) that move food into the gut by closing a tongue-like structure (i.e., radula) during …
An Exploration Of The Effectiveness Of Xanthorrhiza Simplicissima And Its Secondary Alkaloids As Antibiotics Against Staphylococcus Aureus With The Use Of Reserpine, Donald Bothe, Savita Chaurasia
An Exploration Of The Effectiveness Of Xanthorrhiza Simplicissima And Its Secondary Alkaloids As Antibiotics Against Staphylococcus Aureus With The Use Of Reserpine, Donald Bothe, Savita Chaurasia
Undergraduate Theses
Xanthorhiza simplicissima is a plant that is steeped in medical history. It has been used for hundreds of years by the Native Americans, and later by the Europeans, of Appalachia for its medicinal properties. One of the most useful medical applications of this plant are its antibiotic properties, as typified by its use as a tea that was consumed to treat mouth sores. These antibiotic properties can be attributed to some of its secondary alkaloids such as berberine, liriodenine, oxyacanthine, and magnoflorine. These compounds have been studied in other systems; however, oxyacanthine and magnoflorine have not been researched in tandem …
Ultrabithorax, Abdominal-A And Abdominal-B Form Heterodimers And Homodimers In Living Cells By Bifc, Rubén Montalvo Méndez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez
Ultrabithorax, Abdominal-A And Abdominal-B Form Heterodimers And Homodimers In Living Cells By Bifc, Rubén Montalvo Méndez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez
Research Symposium
Background: Hox genes encode transcriptional factors that regulate the expression of specific target genes along the anterior-posterior axis determining the segment identity during embryonic development. These master genes are expressed in the same order in which are located in the third chromosome of Drosophila melanogaster. As it was previously reported the interaction of neighboring Hox proteins as Scr-Antp and Antp-Ubx and one of the mechanisms for Hox protein regulation is protein-protein interaction, we determined the heterodimer formation of Ubx with AbdA and AbdB as well as the homodimer formation of these proteins in living cells which in turn could …
Exploring The Role Of Calcineurin In Filamentation Across Inducing Conditions In The Fungal Pathogen Candida Albicans, Patricia Harte-Maxwell, Jill R. Blankenship
Exploring The Role Of Calcineurin In Filamentation Across Inducing Conditions In The Fungal Pathogen Candida Albicans, Patricia Harte-Maxwell, Jill R. Blankenship
UNO Student Research and Creative Activity Fair
Candida albicans is an opportunistic human pathogenic fungus affecting millions of people globally; high mortality rates are possible in systemic infection. Filamentation or a filamentous growth pattern is a primary virulence mechanism of C. albicans underlying other virulent behaviour....
Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon
Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon
College of Arts & Sciences Senior Theses
With an increase in the average age of the American population, incidents of age-related diseases and illnesses are rising across healthcare communities. Addressing these pathologies with a focus towards novel treatments warrants further research into their mechanistic origins. Lipid build up within cells has been correlated with increased risk for certain pathologies, namely Alzheimer's disease and type-2 diabetes (Demarco, 2020). In this study I aimed to investigate the origin of the increase in lipids, specifically we consider the effects of lipid build up on the maintenance of stem cell populations.
Methamphetamine-Induced Dna Double-Stranded Breaks: The Impact Of The Dopamine Transporter And Insights Into The Mechanisms Of Dna Damage In Mouse Neuro 2a Cells, Lizette Couto
Dissertations, Theses, and Capstone Projects
Methamphetamine (METH) abuse remains a global health concern, with emerging evidence highlighting its genotoxic potential. In the central nervous system METH enters dopaminergic cells primarily through the dopamine transporter (DAT), which controls the dynamics of dopamine (DA) neurotransmission by driving the reuptake of extracellular DA into the presynaptic neuronal cell. Additional effects of METH on the storage of DA in synaptic vesicles lead to the dysregulated cytosolic accumulation of DA. Previous studies have shown that after METH disrupts intracellular vesicular stores of DA, the excess DA in the cytosol is rapidly oxidized. This generates an abundance of reactive oxygen species …
The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson
The Biobehavioral Effects Of Embryonic Exposure To Neural Inflammation And Oxidative Stress In Zebrafish, Dalton J. Anderson
Honors College Theses
The purpose of this research is to improve understanding of the neurodevelopmental effects of embryonic exposure to elevated inflammation and oxidative stress induced by the antipyretic drug acetaminophen (APAP). Our study was the first to examine the interactive effects of APAP and inflammation in zebrafish embryos and how the treatments affect brain development and larval behavior. Experimental groups of zebrafish larvae were exposed to lipopolysaccharide (LPS) to induce inflammation, APAP, or LPS + APAP and larval behavior was analyzed using Ethovision automated behavioral tracking software. We also measured changes in whole-brain Glycogen Synthase Kinase 3 Beta (GSK3B) and GSK3B phosphorylation, …