Other Cell and Developmental Biology Commons^™

Effect Of Glycocalyx On Red Blood Cell Motion In Capillary Surrounded By Tissue, Rekha Bali, Swati Mishra, P. N. Tandon

Applications and Applied Mathematics: An International Journal (AAM)

The aim of the paper is to develop a simple model for capillary tissue fluid exchange system to study the effect of glycocalyx layer on the single file flow of red cells. We have considered the channel version of an idealized Krogh capillary-tissue exchange system. The glycocalyx and the tissue are represented as porous layers with different property parametric values. Hydrodynamic Lubrication theory is used to compute the squeezing flow of plasma within the small gap between the cell and the glycocalyx layer symmetrically surrounded by the tissue. The system of non linear partial differential equations has been solved using …

Optimization Of Protein Expression Of Four Transcription Factors Using Chaperone Proteins, Kaitlin Wilson

Honors Scholar Theses

Embryonic stem cells are unique in their ability to grow indefinitely while maintaining both pluripotency and self-renewal capabilities. These stem cells could be the answer to solving many of the debilitating and devastating diseases suffered by humans. Recently, the use of human derived embryonic stem cells has been effective in animal models in the treatment of spinal cord injuries (Kierstead et al., 2005).

Although the study of embryonic stem cells has become increasingly popular in the last decade, there is still much research to be done to increase the expression of valuable embryonic proteins which will induce pluripotency in the …

Modeling Brain Injury: Expression Of Glial Fibrillary Acidic Protein In Stretch-Injured Astrocytes, Lindsey Cooke

Undergraduate Theses and Capstone Projects

Traumatic brain injury (TBI) is the leading cause of death and disability in individuals under 45. Individuals who survive TBI may be disabled for the rest of their lives and suffer from cognitive, physical, social and financial problems. Following TBI it has been shown that astrocytic gene expression of many proteins, including glial fibrillary acidic protein (GFAP), increases. These “reactive” astrocytes are thought to have both beneficial and detrimental effects on neuronal survival and function. The current study uses an in vitro model of injury which grows astrocytes on deformable silastic membranes to allow for dynamic stretch of cultured cells …

Loss Of Ski Expression In Testicular Cancer Leads To An Enhanced Invasive Phenotype Through Both Bmp-Dependent And Bmp-Independent Pathways, Amy N. Nash

Theses, Dissertations and Capstones

The proto-oncogene SKI is a transcription factor and a co-repressor of the TGFβ superfamily, including TGF

β and BMP. However, additional data suggests that SKI may function as a tumor suppressor in some cell types. The TGFβ superfamily has been implicated in cancer progression and germ cell migration. Testicular cancer afflicts men during their peak reproductive years and is the most common cancer among men of this age group. Cisplatin-based chemotherapy is the standard treatment for testicular cancer. This treatment can lead to undesirable side effects, including infertility. We have shown that SKI expression is decreased in testicular germ cell …