Other Cell and Developmental Biology Commons^™

The Cytotoxicity And Anti-Inflammatory Properties Of 1’S-1’-Acetoxychavicol Acetate (Aca) On Oral Cells, Nur Umairah Atiqah Sabri, Nor Syazwani Muhammad Zahidan, Zulfahmi Said, Siti Noor Adnalizawati Adnan, Normaliza Ab Malik

Journal of Dentistry Indonesia

Objective: Mouthwash is widely used to maintain oral health by reducing the prevalence of pathogenic microbiomes. Nonetheless, chlorhexidine, a common active ingredient, is associated with side effects including teeth staining, mucosal peeling, mouth and tongue numbness. This has prompted interest in natural alternatives. This study aimed to identify the cytotoxicity and anti-inflammatory properties of 1’S-1’-acetoxychavicol acetate (ACA) isolated from Alpinia conchigera rhizome against human primary gingival fibroblast and keratinocyte (HPGF and HPGK). Methods: Cytotoxicity of ACA (1.57 mg/mL) against HPGF and HPGK was assessed using the MTT assay. Meanwhile, the anti-inflammatory property of ACA was analyzed based on …

Investigating Potential Alzheimer's Disease Therapies Through An Agent-Based Model Of Impaired Microglia Metabolismmodeling Impaired Microglia Metabolism, Cheyenne Ty, Abigail Penland, John Gerving, Martin Mendoza-Ceja, Megan Pratt, Kamila Larripa

Spora: A Journal of Biomathematics

Alzheimer’s disease is the leading cause of dementia globally and is marked by amyloid-β plaque accumulation, decreased brain pH, disrupted metabolism, and increased permeability of the blood-brain barrier. Microglia, the resident immune cells of the central nervous system, are essential for maintaining brain homeostasis and are critically involved in the progression of AD. While microglia can initiate protective immune responses to injury and disease, dysregulated microglial metabolism may contribute to the exacerbation of Alzheimer's pathology. To investigate potential therapeutic strategies, we developed an agent-based model simulating the effects of exercise and metabolic enhancement on dysfunctional microglia. Our findings suggest that …

Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy

BAU Journal - Science and Technology

Worldwide, bone fractures are a major public health concern and, there is an urgent requirement to create new treatments to accelerate the rate of the bone healing process. This research mainly relies on creating a hydrogel that satisfies the bone marrow mesenchymal stem cells (BM-MSCs) and makes it a suitable medium to differentiate into osteogenic cells. We combine the BM-MSCs with a chitosan polymer-based hydrogel, infused with PVA to enhance bone healing, this unique mixture forms " Bioink ". We induced a closed fracture model in the rat's right humerus, followed by injection of a single dosage of bioink. On …

Consciousness, Evolution, And The Self-Organizing Brain, Karen Seymour

Journal of Conscious Evolution

While evolution is guided by natural selection, it is internally driven by self-organizing processes. The brain encompasses these complementary forces and dynamics of evolution in both its structure and dynamics by embodying a historical record of the factors that have shaped it throughout its evolutionary past, as well as by being shaped by selective parameters in real time. Self-organization is evident in not only the brain’s structure and form, but also in the processes that support consciousness. From the convergence of complex structure and the novelty-generating dynamics of chaos that both characterize the brain arises the experience of explicit consciousness, …

Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill

SURE Journal: Science Undergraduate Research Experience Journal

Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …

The Bioethical Significance Of “The Origin Of Man’S Ethical Behavior” (October 1941, Unpublished) By Ernest Everett Just And Hedwig Anna Schnetzler Just, Theodore Walker Jr.

Journal of the South Carolina Academy of Science

Abstract –

E. E. Just (1883-1941) is an acknowledged “pioneer” in cell biology, and he is perhaps the pioneer in study of egg cell fertilization. Here we discover that Just also made pioneering contributions to general biology and evolutionary bioethics.

Within Just’s published contributions to observational cell biology, there are substantial fragments of his theory of ethical behavior, a theory with roots in cell biology. In addition to such previously available fragments, Just’s fully developed theory is now available. This recently discovered unpublished book-length manuscript argues for the biological origins of ethical behavior (evolving from cells to humans, within a …

How Cellular Metabolic State And The Chaperone Protein Hsp104 Interact To Affect The Spontaneous Formation Of The Yeast Prion [Ure3], Demyia Graham

Merge

No abstract provided.

Effect Of Glycocalyx On Red Blood Cell Motion In Capillary Surrounded By Tissue, Rekha Bali, Swati Mishra, P. N. Tandon

Applications and Applied Mathematics: An International Journal (AAM)

The aim of the paper is to develop a simple model for capillary tissue fluid exchange system to study the effect of glycocalyx layer on the single file flow of red cells. We have considered the channel version of an idealized Krogh capillary-tissue exchange system. The glycocalyx and the tissue are represented as porous layers with different property parametric values. Hydrodynamic Lubrication theory is used to compute the squeezing flow of plasma within the small gap between the cell and the glycocalyx layer symmetrically surrounded by the tissue. The system of non linear partial differential equations has been solved using …

Reproductive Performance Of Female White-Tailed Deer On Holla Bend National Wildlife Refuge, Thomas A. Nelson

Journal of the Arkansas Academy of Science

Aspects of the reproductive biology of female white-tailed deer (Odocoileus virginianus) on Holla Bend National Wildlife Refuge were investigated by examining the reproductive tracts of 121 deer harvested during the 1985-90 archery seasons. The presence of corpora albicantia in yearlings suggested that 27% of female fawns conceived, producing a mean of 1.0 ova/breeding fawn. Pregnancy rates among yearlings and adults averaged 94% and 97%, respectively. Ovulation rates averaged 1.4 and 2.0 ova/female among yearlings and adults. Some females were ovulating in early-October, but the earliest conceptions occurred during the last week of October. The peak breeding period for yearlings and …

A New Tissue Test For Accurate Diagnosis Of Copper Deficiency In Cereals, J W. Gartrell, A. D. Robson, J. F. Loneragan

Journal of the Department of Agriculture, Western Australia, Series 4

Copper deficiency in ceereals can now be accurately diagnosed using tissue analysis.

Early Hail Marks On Apples Do Not Grow Out, N H. Shorter, J. C. Rowbotham

Journal of the Department of Agriculture, Western Australia, Series 4

ALTHOUGH the 1964/65 season brought a record crop with a good proportion of high quality fruit, the year was marred by several violent hailstorms in separate parts of the South-West.

Hormone Sprays For Apricots, J E L Cripps

Journal of the Department of Agriculture, Western Australia, Series 4

VARIOUS hormone sprays have been applied to apricots with the object of increasing fruit size and hastening maturity, and of these 245TA, the tri-ethanol amine salt of 245 trichlorophenoxyacetic acid, has in general, proved the most successful.

The increase in fruit diameter obtained with this spray in Western Australia has varied between 5 and 15 per cent, and is due to an increase in the size of the cells within the fruit, not to the production of a greater number of cells.