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Full-Text Articles in Other Cell and Developmental Biology
Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon
Investigating The Mechanisms Through Which Autophagy Controls Lipid Levels In Cyst Stem Cells., Jared Langdon
College of Arts & Sciences Senior Theses
With an increase in the average age of the American population, incidents of age-related diseases and illnesses are rising across healthcare communities. Addressing these pathologies with a focus towards novel treatments warrants further research into their mechanistic origins. Lipid build up within cells has been correlated with increased risk for certain pathologies, namely Alzheimer's disease and type-2 diabetes (Demarco, 2020). In this study I aimed to investigate the origin of the increase in lipids, specifically we consider the effects of lipid build up on the maintenance of stem cell populations.
Serpinb1 Effects On Human Pancreatic Ductal Cells, Praneeth Goli
Serpinb1 Effects On Human Pancreatic Ductal Cells, Praneeth Goli
College of Arts & Sciences Senior Theses
Rebuilding or expanding the body’s ability to regulate blood glucose levels by restoring or increasing the body’s ability to produce insulin, long-term, would be a major advancement in diabetes (type-1 and type-2) treatment and could serve as a potential cure [1]. Therefore, the holy grail of diabetes treatment and cure research is to regenerate or increase the insulin producing cells in diabetic individuals (type-1 and type-2) [1, 2]. SerpinB1 has been implicated as a biomolecular signal that stimulates an increase in insulin cell mass in murine and zebrafish models that exhibit physiologically normal compensatory islet hyperplasia. In humans, SerpinB1 is …