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Full-Text Articles in Other Cell and Developmental Biology
Identifying The Molecular Pathways That Drive Retinal Degeneration In The Childhood Neurodegenerative Disease: Mucolipidosis Type Iv, Michael Pamonag
Identifying The Molecular Pathways That Drive Retinal Degeneration In The Childhood Neurodegenerative Disease: Mucolipidosis Type Iv, Michael Pamonag
Masters Theses, 2020-current
Humans, like many other vertebrates, possess five Aristotelian senses (vision, olfaction, hearing, taste, and touch) which we use to experience and navigate our environment. Our visual system is the only source of light detection and light signaling in our bodies. This makes our visual system essential for detecting movement, distance, time of day, and seasonal changes in the length of days within our environment. The visual systems of most animals are designed to capture photons of visible light and convert that energy into a neurological signal (visual signal) to be transmitted to brain regions responsible for visual perception1 . This …
Epigenetic Regulation Of Crx And Nrl Binding To Regulatory Elements In The Genomes Of Human Retinal Neurons, Courtney B. Stout
Epigenetic Regulation Of Crx And Nrl Binding To Regulatory Elements In The Genomes Of Human Retinal Neurons, Courtney B. Stout
Senior Honors Projects, 2010-2019
The retina is a neuronal tissue lining the back of the eye containing rod and cone photoreceptors that make vision possible. Highly regulated transcriptional networks control differentiation and maintenance of photoreceptors in the retina. DNA methylation of cytosine bases in genomic DNA is an epigenetic modification correlated with repression of gene expression. Currently in our lab, the biochemical relationship between DNA methylation and the ability of retina-specific transcription factors to bind in the genome is being studied. These transcription factors, known as cone-rod homeobox (CRX) and neural leucine zipper (NRL), have been shown to act synergistically to control photoreceptor expression …