Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Anatomy (1)
- Biology (1)
- Cell Biology (1)
- Cells (1)
- Developmental Biology (1)
-
- Developmental Neuroscience (1)
- Medical Specialties (1)
- Medicine and Health Sciences (1)
- Microbiology (1)
- Molecular and Cellular Neuroscience (1)
- Neurology (1)
- Neuroscience and Neurobiology (1)
- Organismal Biological Physiology (1)
- Other Cell and Developmental Biology (1)
- Other Life Sciences (1)
- Other Neuroscience and Neurobiology (1)
- Research Methods in Life Sciences (1)
- Systems Biology (1)
- Institution
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Cell Anatomy
Combined 3d Bioprinting And Tissue-Specific Ecm System Reveals The Influence Of Brain Matrix On Stem Cell Differentiation, Martina Zamponi, Peter A. Mollica, Yara Khodour, Julie S. Bjerring, Robert D. Bruno, Patrick C. Sachs
Combined 3d Bioprinting And Tissue-Specific Ecm System Reveals The Influence Of Brain Matrix On Stem Cell Differentiation, Martina Zamponi, Peter A. Mollica, Yara Khodour, Julie S. Bjerring, Robert D. Bruno, Patrick C. Sachs
School of Medical Diagnostics & Translational Sciences Publications
We have previously shown that human and murine breast extracellular matrix (ECM) can significantly impact cellular behavior, including stem cell fate determination. It has been established that tissue-specific extracellular matrix from the central nervous system has the capacity to support neuronal survival. However, the characterization of its influence on stem cell differentiation and its adaptation to robust 3D culture models is underdeveloped. To address these issues, we combined our 3D bioprinter with hydrogels containing porcine brain extracellular matrix (BMX) to test the influence of the extracellular matrix on stem cell differentiation. Our 3D bioprinting system generated reproducible 3D neural structures …
Characterizing The Requirements For The Matricellular Protein, Dccn, In Nervous System Function, Elizabeth L. Catudio Garrett
Characterizing The Requirements For The Matricellular Protein, Dccn, In Nervous System Function, Elizabeth L. Catudio Garrett
Graduate Student Theses, Dissertations, & Professional Papers
The brain is organized as a complex network of specialized neurons that communicate via a combination of electrical and chemical signals. Our brains function to generate movement, control organ function, or direct complex behaviors; all of which requires the ability to regulate the flow of communication between circuits and networks. Work in this thesis addresses two areas of neuron communication: first, how does the release of more than one neurotransmitter from a single neuron impact behavior, and second, are matricellular proteins (MCPs) key contributors to synaptic transmission and neuron function? The conserved CCN family of MCPs have a …