Cell Anatomy Commons^™

The Effect Of Pericyte Cell Therapy On Postischemic Neovascularization In Wild Type And Type 2 Diabetic Mice, Katherine E. Hayes

Doctoral Dissertations

Peripheral artery disease is an atherosclerotic disease that causes limb ischemia and has few effective treatments. Stem cell therapy is a promising treatment option, but concomitant diabetes may limit its effectiveness. The purpose of this study was to evaluate the therapeutic potential of skeletal muscle pericytes to augment postischemic neovascularization following the induction of limb ischemia in wild type and type 2 diabetic (T2DM) mice. The hypothesis was that diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization and differentiate in vivo. Pericytes were isolated via fluorescence activated cell sorting for CD45^-CD34^-CD146 …